Estradiol formation and estrogen receptors in breast tumor tissue: Effects of tamoxifen on estrogen interconversions in breast tumor homogenate in vitro

Homogenates of normal pancreatic tissue obtained from five female and nine male subjects transformed (3H)estrone sulfate into (3H)estrone and (3H)estradiol-17 beta in vitro. No other unconjugated (3H)metabolites were found. The rates of transformation were comparable to those previously demonstrated in mammary carcinoma and greatly exceeded those found in endocrinologically unrelated pectoralis and abdominal muscle. The results may provide additional indications for a possible association between estrogens and pancreatic function.

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Estradiol formation and estrogen receptors in breast tumor tissue: Effects of tamoxifen on estrogen interconversions in breast tumor homogenate in vitro

Cited by 3 publications

References 7 publications

Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal breast cancer patients

Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal breast cancer patients

Metabolism of estrone sulfate in endometriotic tissue and in uterine endometrium in proliferative and secretory cycle phase

Metabolism of Estrone Sulfate by Normal Human Pancreatic Tissue in Vitro

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