Estradiol effect on short-term object memory under hypocholinergic condition

Pereira, Luciana Melo; Guimaraes, Isabella M; Oliveira, Vinícius Elias de Moura; Bastos, Cristiane Perácio; Ribeiro, Fabíola M.; Prado, Vânia F.; Prado, Marco A. M.; Pereira, Grace Schenatto

doi:10.1016/j.brainresbull.2018.01.012

Cited by 6 publications

(3 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, despite their behavioral relevance at the time of their existence, most short-term memories do not actually need to be (and are not) consolidated into long-term memories. In view of its functional significance, it is thus unsurprising that a vast literature (human and nonhuman animal) has demonstrated that short-term memory is a separate process, with underlying mechanisms that do not always overlap with those mediating the consolidation, storage, and retrieval of long-term memories (e.g., [14][15][16][17] ; reviewed in 13,18,19 ).…”

Section: Introductionmentioning

confidence: 99%

Membrane receptors mediate the rapid facilitation of short‐term memory by estradiol in the dorsal hippocampus of female mice

Kuun‐Hadden

Brar

Klemens

et al. 2023

J Neuroendocrinology

View full text Add to dashboard Cite

Estrogens play a key role in learning and memory via delayed genomic and early‐onset rapid mechanisms. Systemic treatment with 17β‐estradiol (E2) rapidly facilitates object recognition, social recognition and object placement short‐term memory in ovariectomized female mice within a timescale of only 40 min following administration. The dorsal hippocampus is one critical site of rapid estrogenic effects. Estrogen receptors (ER) are located in the cell nucleus, cytoplasm and membrane. Membrane ERs alone can mediate the rapid facilitation of long‐term memory consolidation by estrogens. This study determined the role of membrane ERs in the rapid effects of 17‐β estradiol (E2) on short‐term memory within the dorsal hippocampus of ovariectomized mice. We infused E2 conjugated to bovine serum albumin (BSA‐E2) that prevents it from crossing the cell membrane and found that the rapid facilitation by E2 of short‐term memory in the social recognition, object recognition and object placement tasks is mediated by membrane ERs, independently of intracellular receptors.

show abstract

Section: Introductionmentioning

confidence: 99%

Membrane receptors mediate the rapid facilitation of short‐term memory by estradiol in the dorsal hippocampus of female mice

Kuun‐Hadden

Brar

Klemens

et al. 2023

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation

Sheppard

Chandramohan

Lumsden

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Social memory is essential to the functioning of a social animal within a group. Estrogens can affect social memory too quickly for classical genomic mechanisms. Previously, 17β-estradiol (E2) rapidly facilitated short-term social memory and increased nascent synapse formation, these synapses being potentiated following neuronal activity. However, what mechanisms underlie and coordinate the rapid facilitation of social memory and synaptogenesis are unclear. Here, the necessity of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) signaling for rapid facilitation of short-term social memory and synaptogenesis was tested. Mice performed a short-term social memory task or were used as task-naïve controls. ERK and PI3K pathway inhibitors were infused intradorsal hippocampally 5 min before E2 infusion. Forty minutes following intrahippocampal E2 or vehicle administration, tissues were collected for quantification of glutamatergic synapse number in the CA1. Dorsal hippocampal E2 rapid facilitation of short-term social memory depended upon ERK and PI3K pathways. E2 increased glutamatergic synapse number (bassoon puncta positive for GluA1) in task-performing mice but decreased synapse number in task-naïve mice. Critically, ERK signaling was required for synapse formation/elimination in task-performing and task-naïve mice, whereas PI3K inhibition blocked synapse formation only in task-performing mice. While ERK and PI3K are both required for E2 facilitation of short-term social memory and synapse formation, only ERK is required for synapse elimination. This demonstrates previously unknown, bidirectional, rapid actions of E2 on brain and behavior and underscores the importance of estrogen signaling in the brain to social behavior.

show abstract

“…In view of their differing behavioral significance, it is perhaps unsurprising that the molecular underpinnings of short-term and long-term memory do not fully overlap (e.g. (37,38) but see (39,40) for discussion). The rapid and transient creation by estrogens of neuronal substrate for memory encoding provides a highly dynamic mechanism for short-term memory processing, especially in information rich, dynamic environments such as social interactions.…”

Section: Introductionmentioning

confidence: 99%

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation

Sheppard

Chandramohan

Lumsden

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Social memory is essential to the functioning of a social animal within a group. Estrogens can affect social memory too quickly for classical genomic mechanisms. Previously, 17β-estradiol (E2) rapidly facilitated short-term social memory and increased nascent synapse formation, these synapses being potentiated following neuronal activity. However, what mechanisms underlie and co-ordinate the rapid facilitation of social memory and synaptogenesis are unclear. Here, the necessity of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) signaling for rapid facilitation of short-term social memory and synaptogenesis was tested. Methods: Mice performed a short-term social memory task or were used as task-naïve controls. ERK and PI3K pathway inhibitors were infused intra-dorsal hippocampally 5 minutes before E2 infusion. Forty minutes following intrahippocampal E2 or vehicle administration, tissues were collected for quantification of glutamatergic synapse number in the CA1. Results: Dorsal hippocampal E2 rapid facilitation of short-term social memory depended upon ERK and PI3K pathways. E2 increased glutamatergic synapse number (GluA1/bassoon colocalization) in task-performing mice but decreased synapse number in task-naïve mice. Critically, ERK signaling was required for synapse formation/elimination in task-performing and task-naïve mice, whereas PI3K inhibition blocked synapse formation only in task-performing mice. Conclusions: Whilst ERK and PI3K are both required for E2 facilitation of short-term social memory and synapse formation, only ERK is required for synapse elimination. This demonstrates previously unknown, bidirectional, rapid actions of E2 on brain and behaviour and underscores the importance of estrogen signaling in the brain to social behaviour.

show abstract

Estradiol effect on short-term object memory under hypocholinergic condition

Cited by 6 publications

References 62 publications

Membrane receptors mediate the rapid facilitation of short‐term memory by estradiol in the dorsal hippocampus of female mice

Membrane receptors mediate the rapid facilitation of short‐term memory by estradiol in the dorsal hippocampus of female mice

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation

Contact Info

Product

Resources

About