Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeys

Lacreuse, Agnès; Wilson, Mark; Herndon, James G.

doi:10.1016/s0197-4580(02)00002-7

Cited by 118 publications

(89 citation statements)

References 102 publications

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“…Daniel and colleagues (Daniel et al 2006) showed that if E2 is administered to rats immediately following ovarectomy, improvements are seen in acquisition and delay trials of a working memory task, but not seen if E2 administration is delayed for up to five months. However some primate studies have shown that E2 benefits cognitive performance even when administration is delayed after ovarectomy or natural menopause even for several years (Lacreuse 2006;Lacreuse et al 2002;Rapp et al 2003). The reason for this discrepancy is not clear, but the length of the "window" or critical period may be quite different depending on the natural lifespan of the animal.…”

Section: Discussionmentioning

confidence: 99%

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas

Hancur-Bucci

Naylor

et al. 2008

Hormones and Behavior

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Estradiol has been shown to interact with the cholinergic system to affect cognition in postmenopausal women. This study further investigated the interaction of estradiol and cholinergic system functioning on verbal memory and attention in two groups of healthy younger (ages 50-62) and older (ages 70-80) postmenopausal women. Twenty-two postmenopausal women were randomly and blindly placed on 1 mg of 17-beta estradiol orally for one month then 2 mg for two months or matching placebo pills after which they participated in three anticholinergic challenge sessions when verbal memory performance was assessed. Subjects were administered either the antimuscarinic drug scopolamine (SCOP), the antinicotinic drug mecamylamine (MECA) or placebo. After the first challenge phase, they were crossed over to the other hormone treatment for another three months and repeated the challenges. Results showed that estradiol pretreatment significantly attenuated the anticholinergic drug-induced impairments on a test of episodic memory (the Buschke Selective Reminding test) for the younger group only, while estradiol treatment impaired performance of the older group. The results suggest that younger subjects may experience more cholinergic benefit from estradiol treatment than older subjects, supporting the concept of a critical period for postmenopausal estrogen use.

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Section: Discussionmentioning

confidence: 99%

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas

Hancur-Bucci

Naylor

et al. 2008

Hormones and Behavior

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show abstract

“…Shaywitz et al (Shaywitz et al, 1999) have shown with 46 post-menopausal women that estrogen intake modulates the activation of the inferior parietal lobule, increasing it during storage of verbal material and decreasing it during storage of non-verbal material. Furthermore, estrogens improve visuo-spatial memory in ovariectomized rhesus monkeys (Lacreuse, Wilson, & Herndon, 2002) and in rats (Lund et al, 2001). Conversely, knockout mice for the estrogen beta receptor fail to learn spatial tasks (Rissman, Heck, Leonard, Shupnik, & Gustafsson, 2002).…”

Section: Discussionmentioning

confidence: 99%

A cognitive characterization of dyscalculia in Turner syndrome

et al. 2004

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Current theories of number processing postulate that the human abilities for arithmetic are based on cerebral circuits that are partially laid down under genetic control and later modified by schooling and education. This view predicts the existence of genetic diseases that interfere specifically with components of the number system. Here, we investigate whether Turner syndrome (TS) corresponds to this definition. TS is a genetic disorder which affects one woman in 2500 and is characterized by partial or complete absence of one X chromosome. In addition to well-characterized physical and hormonal dysfunction, TS patients exhibit cognitive deficits including dyscalculia. We tested 12 women with Turner syndrome and 13 control subjects on a cognitive battery including arithmetical tests (addition, subtraction, multiplication, division) as well as tests of the understanding of numerosity and quantity (cognitive estimation, estimation, comparison, bisection, subitizing/counting). Impairments were observed in cognitive estimation, subitizing, and calculation. We examine whether these deficits can be attributed to a single source, and discuss the possible implications of hormonal and genetic factors in the neuropsychological profile of TS patients.

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“…Finally, for both estrogen and BDNF, the effects that have been observed exhibit unique and characteristic response patterns, that are not shared by any other humoral agent. Thus, estrogen has striking effects that range from alterations in behavior [5][6][7][8][9][10][11][12][13], structure (spine morphology, density, and spine synapses; Table 2), and physiology (potentiation of glutamatergic inputs in area CA1; Table 2) including specific receptormediated actions, such as actions at the NMDA receptor (although not exclusively; [14]). BDNF is the one other molecule that has been shown to exert many, if not all, of these same specific effects (Table 2).…”

Section: Estrogen and Bdnf In Hippocampus A Rationalementioning

confidence: 99%

“…This has been shown for male rats after manipulations that increase estradiol, and the reverse, that learning is worse when estradiol levels are low, for example in aromatase-knockout mice [42]. This has also been studied in female rats after ovariectomy and estradiol replacement, although it is difficult to compare some of these studies because doses of estradiol vary, as well as other potential factors such as age, time after ovariectomy, and housing [5][6][7][8][9][11][12][13]43]. The variability occurs not only in whether behavior is enhanced, but also the type of task.…”

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

“…The variability occurs not only in whether behavior is enhanced, but also the type of task. Thus, many studies of spatial learning (a classic hippocampal-dependent behavior) show an improvement after estradiol administration, but other types of memory can sometimes also improve, suggesting not only hippocampal effects but also non-hippocampal effects [5][6][7][8][9][11][12][13]43]. Learning appears to be enhanced on the morning of proestrus relative to other cycle stages or relative to ovariectomy [44].…”

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

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Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Scharfman

MacLusky

2006

Frontiers in Neuroendocrinology

266

202

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In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and mechanisms of action. The demonstration of an estrogen-sensitive response element on the BDNF gene provided an impetus to explore a direct relationship between estrogen and BDNF, and predicted that the effects of estrogen, at least in part, might be due to the induction of BDNF. This hypothesis is discussed with respect to the hippocampus, where substantial evidence has accumulated in favor of it, but alternate hypotheses are also raised. It is suggested that some of the interactions between estrogen and BDNF, as well as the controversies and implications associated with their respective actions, may be best appreciated in light of the ability of BDNF to induce neuropeptide Y (NPY) synthesis in hippocampal neurons. Taken together, this tri-molecular cascade, estrogen-BDNF-NPY, may be important in understanding the hormonal regulation of hippocampal function. It may also be relevant to other regions of the CNS where estrogen is known to exert profound effects, such as amygdala and hypothalamus; and may provide greater insight into neurological disorders and psychiatric illness, including Alzheimer's disease, depression and epilepsy.

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Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeys

Cited by 118 publications

References 102 publications

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

A cognitive characterization of dyscalculia in Turner syndrome

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

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