Estradiol and striatal dopamine receptor antagonism influence memory system bias in the female rat

Quinlan, Matthew G.; Almey, Anne; Caissie, Meghen; LaChappelle, Ivonne; Radiotis, George; Brake, Wayne G.

doi:10.1016/j.nlm.2013.08.018

Cited by 27 publications

(26 citation statements)

References 39 publications

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“…These findings suggest that disrupted global DA transmission impact how E2 affects strategy use, possibly due to altered striatal DA function. This was confirmed in a follow-up study: it was shown that infusing the same DA antagonists directly into the dorsal, but not the ventral, striatum lead to a different memory bias in OVX rats receiving both low and high E2 replacement [154]. However, this effect was only observed following administration of the D1R antagonist, with no effects observed after the D2R antagonist was infused into the dorsal striatum, suggesting that another brain region may also be mediating multiple memory system bias and how E2 affects it in particular.…”

Section: Hormones Reproductive Experience and Multiple Memory Systemsmentioning

confidence: 67%

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Estrogen and memory system bias in females across the lifespan

Hussain

Shams

Brake

2014

Translational Neuroscience

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Studies in both rodents and humans have made much progress in shedding light on how fluctuations in ovarian hormones can affect memory in women across the lifespan. Specifically, advances in neuroscience have identified multiple memory systems that are each mediated by different brain areas. Two memory systems used to navigate an environment are 'place' and 'response' memory. They are defined as either using an allocentric strategy: using a spatial or cognitive map of the surroundings, or an egocentric strategy: using habitual-turns/ movements, respectively. Studies in neuroendocrinology have shown that estrogen levels can bias a female to use one memory system over another to solve a task, such that high estrogen levels are associated with using place memory and low levels with using response memory. Furthermore, recent advances in identifying and localizing estrogen receptors in the rodent brain are uncovering which brain regions are affected by estrogen and providing insight into how hormonal fluctuations during the menstrual cycle, pregnancy, and menopause might affect which memory system is facilitated or impaired in women at different life stages. These studies can help point the way to improving cognitive health in women. Estrogen and cognitionModern Western society is not only marked by longer life expectancies, but young women are also waiting longer to have children and having fewer of them, therefore having more menstrual cycles in their lifetimes than ever before. Progesterone (P) and 17β-estradiol (E2; the most potent of the estrogens during reproductive years) vary across the menstrual cycle in a consistent and fluctuating manner.During the first half of the cycle, or follicular phase, E2 and P levels are low; E2 levels then start to increase steadily at the end of menstruation, reaching a peak in the middle of the menstrual cycle, right before ovulation occurs. This is followed by the luteal phase, when E2 levels plateau while P levels increase and peak until menstruation begins again (Figure 1). Thus, E2 and P work hand in hand across a woman's cycle to orchestrate menstruation, ovulation, and conception.However, these hormones appear to be exerting other effects on the female brain, which could be subject to subtle changes as hormone levels fluctuate over time. human menstrual cycle (top panel) and the ~4 day rat estrous cycle (bottom panel). Human menstrual cycle begins with a follicular (mentrual and preovulatory) phase, followed by ovulation, and ends with a luteal phase (spanning end of ovulation to pre-menstrual phase).

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Section: Hormones Reproductive Experience and Multiple Memory Systemsmentioning

confidence: 67%

“…In an ambiguous T-maze task in which both learning strategies can be used to solve the task, it's been repeatedly observed that OVX rats given high E2 replacement predominantly use place memory, whereas the opposite pattern is seen in those with low or no E2 replacement [47,48,154]. Figure 4.…”

Section: Hormones Reproductive Experience and Multiple Memory Systemsmentioning

confidence: 99%

Estrogen and memory system bias in females across the lifespan

Hussain

Shams

Brake

2014

Translational Neuroscience

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“…In females, estrogen acting via estrogen receptor alpha (ESR1) or estrogen receptor beta (ESR2) is a primary regulator of dopamine transport and signaling in various brain regions, including the NAc (Almey et al 2015; Chavez et al 2010; Febo et al 2003; Hruska and Pitman 1982; Kurling-Kailanto et al 2010; Le Saux et al 2006; Menniti and Baum 1981; Quinlan et al 2013; Tobiansky et al 2016; Uban et al 2012). Under normal physiological conditions, estrogen stimulates dopamine release and signaling pathways in the striatum and NAc of females but not males (Becker 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In females, disruption of estrogen through pharmacological inhibition or ovariectomy, results in dopamine-dependent memory deficits (Quinlan et al 2013) and altered response to psychostimulants and other pleasure seeking behaviors (Febo et al 2003; Tobiansky et al 2016; Zhou et al 2002). Voluntary physical activity or exercise may be considered a hedonistic behavior, as it is stimulates endorphins and other endogenous opioids (Schwarz and Kindermann 1992; Sforzo 1989).…”

Section: Discussionmentioning

confidence: 99%

Sex‐dependent differences in voluntary physical activity

Rosenfeld

2016

J of Neuroscience Research

113

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There are increasing numbers of overweight and obese individuals in the US and globally, and correspondingly, the associated healthcare costs are rising dramatically. More than one-third of children are currently considered obese with a predisposition to type 2 diabetes, and it is likely that their metabolic conditions will worsen with age. Physical inactivity has also risen to be the leading cause of many chronic, non-communicable diseases (NCD). Children are more physically inactive now than they were in past decades, which may be due to intrinsic and extrinsic factors. In rodents, the amount of time engaged in spontaneous activity within the home cage is a strong predictor of later adiposity and weight gain. Thus, it is important to understand primary motivators stimulating physical activity (PA). There are normal sex differences in PA levels in rodents and humans. The perinatal environment can induce sex-dependent differences in PA disturbances. This review will consider the current evidence that there are sex differences in PA in rodents and humans. The rodent studies showing that early exposure to environmental chemicals can shape later adult PA responses will be discussed. Next, an exploration of whether there are different motivators stimulating exercise in male vs. female humans will be examined. Finally, the brain regions, genes, and pathways, that modulate PA in rodents, and possibly by translation humans, will be described. A better understanding of why each sex remains physically active through the lifespan could open up new avenues to prevent and treat obesity in children and adults.

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“…Interestingly, female hormones, such as estrogen and P4, regulate various neurotransmitter signaling pathways in brain regions implicated in OCD (Dreher et al, 2007; Karakaya et al, 2007; Benmansour et al, 2009; Alonso et al, 2011; Quinlan et al, 2013; Barth et al, 2015). During the estrous phase, circulating estrogen levels are higher and serotonin release is lower in striatal neurons (Yang et al, 2015), while in the frontal cortex, estrogen depletion by ovariectomy (OVX) decreases 5-HT2A receptor density and mRNA levels (Cyr et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Ovarian Sex Hormones Modulate Compulsive, Affective and Cognitive Functions in A Non-Induced Mouse Model of Obsessive-Compulsive Disorder

Mitra

Bastos

Bates

et al. 2016

Front. Behav. Neurosci.

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There is currently a lack of understanding of how surgical menopause can influence obsessions, compulsions and associated affective and cognitive functions in female obsessive-compulsive disorder (OCD) patients. Early menopause in women due to surgical removal of ovaries not only causes dramatic hormonal changes, but also may induce affective and cognitive disorders. Here, we tested if surgical removal of ovaries (ovariectomy, OVX), which mimics surgical menopause in humans, would result in exacerbation of compulsive, affective and cognitive behaviors in mice strains that exhibit a spontaneous compulsive-like phenotype. Female mice from compulsive-like BIG, non-compulsive SMALL and randomly-bred Control strains were subjected to OVX or sham-surgery. After 7 days animals were tested for nest building and marble burying to measure compulsive-like behavior. The elevated plus maze and open field tests measured anxiety-like behaviors, while memory was assessed by the novel object recognition. Acute OVX resulted in exacerbation of compulsive-like and anxiety-like behaviors in compulsive-like BIG mice. No significant effects of OVX were observed for the non-compulsive SMALL and Control strains. Object recognition memory was impaired in compulsive-like BIG female mice compared to the Control mice, without an effect of OVX on the BIG mice. We also tested whether 17 β-estradiol (E2) or progesterone (P4) could reverse the effects of OVX. E2, but not P4, attenuated the compulsive-like behaviors in compulsive-like BIG OVX female mice. The actions of the sex steroids on anxiety-like behaviors in OVX females were strain and behavioral test dependent. Altogether, our results indicate that already existing compulsions can be worsened during acute ovarian deprivation concomitant with exacerbation of affective behaviors and responses to hormonal intervention in OVX female mice can be influenced by genetic background.

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Estradiol and striatal dopamine receptor antagonism influence memory system bias in the female rat

Cited by 27 publications

References 39 publications

Estrogen and memory system bias in females across the lifespan

Estrogen and memory system bias in females across the lifespan

Sex‐dependent differences in voluntary physical activity

Ovarian Sex Hormones Modulate Compulsive, Affective and Cognitive Functions in A Non-Induced Mouse Model of Obsessive-Compulsive Disorder

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