Estimulación magnética transcraneal theta-burst intermitente para el tratamiento de la espasticidad en pacientes con esclerosis múltiple recurrente: resultados de un ensayo clínico aleatorizado doble ciego

Diéguez-Varela, C.; Lion-Vázquez, Susana; Fraga-Bau, Arturo; Rodríguez‐Acevedo, Breogán; Rodríguez-Sánchez, Lucía; Collazo-Diéguez, Mónica; Pereira-Martinez, M.N.; Salgado‐Barreira, Ángel; Álvarez-Rodríguez, Elena; Vicente-Alba, Pablo; Muñoz, Delicias; Fernández, José M.; Ribeiro, Sandro Jorge Tavares; Midaglia, Luciana

doi:10.33588/rn.6902.2018275

Cited by 4 publications

(18 citation statements)

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“…The experimental groups received conventional physiotherapy treatment (CPT) plus intermittent iTBS, 42 rTMS, 36 high and low rTMS frequencies, 39 CPT plus rTMS, 37 high-frequency rTMS plus CPT and iTBS plus CPT, 43 iTBS, 38 and iTBS and iTBS plus exercise therapy. 40 The comparison control groups received CPT plus sham iTBS, 42 sham rTMS, 36,39 CPT plus sham rTMS, 37,43 sham iTBS, 38 and sham iTBS plus exercise therapy. 40 The included studies used various rTMS stimulators, such as Magstim Rapid2 stimulator (Magstim Company, Whitland, Wales, UK), 42 Cool-B65 Coil (Magventure, DK), 36 MagStim Rapid magnetic stimulator (Magstim Company, Whitland, Wales, UK), 39 Single-pulse TMS with the NBS eXimia Nexstim tool (Finland), 43 and Magstim Co., Whitland, Dyfed, UK.…”

Section: Intervention Rtmsmentioning

confidence: 99%

“…40 The comparison control groups received CPT plus sham iTBS, 42 sham rTMS, 36,39 CPT plus sham rTMS, 37,43 sham iTBS, 38 and sham iTBS plus exercise therapy. 40 The included studies used various rTMS stimulators, such as Magstim Rapid2 stimulator (Magstim Company, Whitland, Wales, UK), 42 Cool-B65 Coil (Magventure, DK), 36 MagStim Rapid magnetic stimulator (Magstim Company, Whitland, Wales, UK), 39 Single-pulse TMS with the NBS eXimia Nexstim tool (Finland), 43 and Magstim Co., Whitland, Dyfed, UK. 38,40 The coils were located over the contralateral primary motor area of the more affected lower limb, 36,[38][39][40]42 the vertex region targeting the lower extremity (adductors) motor area, 37 and both primary motor areas.…”

Section: Intervention Rtmsmentioning

confidence: 99%

“…43 T A B L E 1 Study characteristics and outcome measures. Frequencies were set at 1 Hz, 39 5 Hz, [36][37][38][39][40]42,43 and 20 Hz. 43 Resting motor thresholds were set at 50%, 42 100%, 36,39 and 110%.…”

Section: Intervention Rtmsmentioning

confidence: 99%

“…Frequencies were set at 1 Hz, 39 5 Hz, [36][37][38][39][40]42,43 and 20 Hz. 43 Resting motor thresholds were set at 50%, 42 100%, 36,39 and 110%. 37 Pulses were set at 100 ms 38,40 and 200 ms. 36,39 Amplitudes were set at 50 μV 39,43 and 200 μV.…”

Section: Intervention Rtmsmentioning

confidence: 99%

“…43 Resting motor thresholds were set at 50%, 42 100%, 36,39 and 110%. 37 Pulses were set at 100 ms 38,40 and 200 ms. 36,39 Amplitudes were set at 50 μV 39,43 and 200 μV. 36,38,40,42 The total stimuli that were delivered were 600, 36,38,40,42 900, 37,39 1200, 43 and 1600.…”

Section: Intervention Rtmsmentioning

confidence: 99%

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Noninvasive brain stimulation for spasticity rehabilitation in multiple sclerosis: A systematic review of randomized controlled trials

Alashram,

Janada,

Ghrear

2023

PM&R

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ObjectivesTo investigate the effects of noninvasive brain stimulation (NIBS) on spasticity in people with multiple sclerosis (PwMS).Literature surveyWe searched PubMed, SCOPUS, MEDLINE, REHABDATA, PEDro, CINAHL, AMED, and Web of Science until December 2022.MethodologyStudies were selected if they included PwMS, using transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) as a main intervention, and the study was a randomized controlled trial (RCT) including at least one outcome measure evaluating spasticity. Two researchers individually screened the selected studies. The study's quality was assessed using the Cochrane Collaborations tool. The researchers decided that the meta‐analysis was not possible because the treatment interventions varied among the selected studies.SynthesisIn total, 147 studies were reviewed. Of them, nine studies met the eligibility criteria and included 193 PwMS (mean age = 43.25), 54.4% of whom were females. Eight studies considered "high" quality and one considered "moderate" quality. Seven studies that used rTMS demonstrated a significant decrease in spasticity in PwMS after the intervention. The remaining studies that provided tDCS did not show meaningful effects.ConclusionsThe evidence for the influences of rTMS on spasticity in PwMS is promising. The evidence for the impact of tDCS on spasticity in PwMS was limited. Further RCTs with long‐term follow‐ups are encouraged.This article is protected by copyright. All rights reserved.

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Section: Intervention Rtmsmentioning

confidence: 99%

Section: Intervention Rtmsmentioning

confidence: 99%

Section: Intervention Rtmsmentioning

confidence: 99%

Section: Intervention Rtmsmentioning

confidence: 99%

Section: Intervention Rtmsmentioning

confidence: 99%

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Noninvasive brain stimulation for spasticity rehabilitation in multiple sclerosis: A systematic review of randomized controlled trials

Alashram,

Janada,

Ghrear

2023

PM&R

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Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis

Su,

Wang,

Zhu

et al. 2023

Braz J Med Biol Res

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Pilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rTMS and sham stimulation in patients with MS-related spasticity. Two reviewers independently selected studies and extracted data on study design, quality, clinical outcomes, and time points measured. The primary outcome was clinical spasticity relief after intervention. Secondary outcomes included spasticity at the follow-up visit 2 weeks later and post-treatment fatigue. Of 831 titles found, we included 8 studies (181 participants) in the quantitative analysis. Pooled analyses showed that rTMS therapy was associated with significant spasticity relief in the early post-intervention period [standardized mean differences (SMD): -0.67; 95%CI: -1.12 to -0.21], but there was insufficient evidence for rTMS in reducing spasticity at the follow-up visit 2 weeks later (SMD: -0.17; 95%CI: -0.52 to 0.17) and fatigue (SMD: -0.26; 95%CI: -0.84 to 0.31). This evidence supports the recommendations to treat MS-related spasticity with rTMS, but underlines the need for further large randomized trials.

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Clinical application of transcranial magnetic stimulation in multiple sclerosis

Zhou

Chen

et al. 2022

Front. Immunol.

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Multiple sclerosis (MS) is a common chronic, autoimmune-mediated inflammatory and neurodegenerative disease of the central nervous system. The treatment of MS has enormous progress with disease-modifying drugs, but the complexity of the disease course and the clinical symptoms of MS requires personalized treatment and disease management, including non-pharmacological treatment. Transcranial magnetic stimulation (TMS) is a painless and non-invasive brain stimulation technique, which has been widely used in neurological diseases. In this review, we mainly focus on the progress of physiological assessment and treatment of TMS in MS.

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Estimulación magnética transcraneal theta-burst intermitente para el tratamiento de la espasticidad en pacientes con esclerosis múltiple recurrente: resultados de un ensayo clínico aleatorizado doble ciego

Cited by 4 publications

References 0 publications

Noninvasive brain stimulation for spasticity rehabilitation in multiple sclerosis: A systematic review of randomized controlled trials

Noninvasive brain stimulation for spasticity rehabilitation in multiple sclerosis: A systematic review of randomized controlled trials

Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis

Clinical application of transcranial magnetic stimulation in multiple sclerosis

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