Estimation the level of Gremlin in Polycystic ovarian syndrome patients

Abstract

Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. The aim of the current study were to detect the analytic estimation of serum Neudesin as well as studying the relation between this biomarker and Body Mass Index (BMI), age, waist /hip ratio and type of infertility in Polycystic ovarian syndrome patients. Methods: The current study was conducted on 90 women (60 patients with polycystic ovary syndrome and 30 healthy control) ranging in their ages from 15-39 years in period from March to June, 2023. Blood samples were collected from women and serum samples prepare to estimate the serum levels of Neudesin. Results: The results indicated that there was a significant decrease (P-Value< 0.05) in Neudesin levels in patients group when compare with control group. Also, after dividing the group of patients into three groups according to ages, we notice a significant decrease (P-Value< 0.05) in Neudesin levels in age less than 20 years when compare with age 20-29 years and age 30-39 years, and a significant decrease (P-Value< 0.05) in Neudesin levels in age 20-29 years when compare with age 30-39 years. On the other hand, When dividing the group of patients according to body mass index we notice a significant increase (P-Value< 0.05) in Neudesin level in overweight group when compare with obese group and significant increase(P-Value< 0.05) in Neudesin level in moderate W/H ratio group than high W/H ratio group and no significant difference found between primary and secondary infertility. Conclusion: The current study concluded that a Neudesin is a prognostic marker and early detection of polycystic ovarian syndrome.