ESTIMATION OR QUANTIFICATION OF TUMOUR VOLUME?. CT study on irregular phantoms

Tiitola, M.; Kivisaari, Leena; Tervahartiala, Pekka; Palomäki, Maarit; Kivisaari, Riku; Mankinen, P; Vehmas, Tapio

doi:10.1034/j.1600-0455.2001.042001101.x

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…In patients with advanced head and neck cancer, Rudat et al [27] reported precision and reliability of the CT based volume measurements by repeated measurements using irregularly shaped phantoms. Furthermore, Titola et al [28] proposed that one-dimensional volume estimation of irregularly shaped tumor-like phantoms should be substituted by true computer-based volume calculations.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of gross tumor volume delineated by FDG-PET-CT based radiotherapy treatment planning in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

et al. 2012

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BackgroundWe aimed to assess whether gross tumor volume (GTV) determined by fusion of contrast-enhanced computerized tomography (CT) and 18F-fluoro-deoxy-D-glucose positron emission tomography-CT (FDG-PET-CT) based radiotherapy planning could predict outcomes, namely overall survival (OS), local-regional progression-free survival (LRPFS), and progression-free survival (PFS) in cases with locally advanced pancreas cancer (LAPC) treated with definitive concurrent chemoradiotherapy.MethodsA total of 30 patients with histological proof of LAPC underwent 50.4 Gy (1.8 Gy/28 fractions) of radiotherapy concurrent with continuously infused 5-FU followed by 4 to 6 courses of maintenance gemcitabine. Target volume delineations were performed on FDG-PET-CT-based RTP. Patients were stratified into 2 groups: GTV lesser (GTVL) versus greater (GTVG) than cut off value determined by receiver operating characteristic (ROC) analysis, and compared in terms of OS, LRPFS and PFS.ResultsMedian GTV delineated according to the FDG-PET-CT data was 100.0 cm3. Cut off GTV value determined from ROC curves was 91.1 cm3. At a median follow up of 11.2 months, median OS, LRPFS and PFS for the entire population were 10.3, 7.8 and 5.7 months, respectively. Median OS, LRPFS and PFS for GTVL and GTVG cohorts were 16.3 vs. 9.5 (p = 0.005), 11.0 vs. 6.0 (p = 0.013), and 9.0 vs. 4.8 months (p = 0.008), respectively.ConclusionsThe superior OS, LRPFS and PFS observed in GTVL patients over GTVG ones suggests a potential for FDG-PET-CT-defined GTV size in predicting outcomes of LAPC patients treated with definitive C-CRT, which needs to be validated by further studies with larger cohorts.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of gross tumor volume delineated by FDG-PET-CT based radiotherapy treatment planning in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

et al. 2012

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Measurement of Observer Agreement

2003

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Statistical measures are described that are used in diagnostic imaging for expressing observer agreement in regard to categorical data. The measures are used to characterize the reliability of imaging methods and the reproducibility of disease classifications and, occasionally with great care, as the surrogate for accuracy. The review concentrates on the chance-corrected indices, kappa and weighted kappa. Examples from the imaging literature illustrate the method of calculation and the effects of both disease prevalence and the number of rating categories. Other measures of agreement that are used less frequently, including multiple-rater kappa, are referenced and described briefly.

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