Estimation of vitamin D levels in patients with pemphigus vulgaris

Abstract

Patients with PV have significantly lower serum vitamin D levels in comparison to controls and that these low levels were not related to age, BMI or pattern of sun exposure. The associated Vitamin D insufficiency in patients with PV may possibly exacerbate their disease through various immune related mechanisms.

A review of case–control studies on the risk factors for the development of autoimmune blistering diseases

“…[41][42][43] The results of these studies, however, are statistically powerless and inconclusive due to their small sample sizes. [41][42][43] The results of these studies, however, are statistically powerless and inconclusive due to their small sample sizes.…”

Calcitriol exerts anti‐inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid

“…Indirect evidence for a protective role of vitamin D with respect to autoimmune skin blistering comes from recent studies, which investigated serum vitamin D levels in patients with autoimmune bullous diseases . Similar to other autoimmune disorders like multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus, significantly lower serum vitamin D levels were found in pemphigus and pemphigoid patients compared to controls, suggesting that vitamin D insufficiency is a potential risk factor for development or exacerbation of these diseases .…”

Pemphigus Diagnostikos Ir Gydymo Aktualijos

“…Naudoti raktažodžiai: "pemphigus", "autoantibody", "desmogleins", "immunofluorescence", "pemphigus vulgaris", "pemphigus foliaceus", "paraneoplastic pemphigus", "systemic corticosteroids". [3,6,10,13,[16][17][18][19] Pemphigus etiologija ir patogenezė. Pemphigus -tai heterogeniška autoimuninė odos ir gleivinių liga, susijusi su autoantikūnų (autoAk) imunoglobulino G (IgG) ir imunoglobulino A (IgA) gamyba prieš skirtingas adhezijos molekules epidermyje ir pasireiškianti intraepiderminėmis akantolitinėmis pūslėmis.…”

“…Yra tyrimų, rodančių, kad pacientams, sergantiems PV, iki pradedant gydymą, nustatoma ryškiai sumažėjusi vitamino D koncentracija. Tačiau iki šiol nepagrįsta įtaka ligos patofiziologiniam mechanizmui [17]. Būtina perspėti pacientus vengti per ilgo buvimo saulėje, nevalgyti labai karšto, aštraus maisto, prieš vartojant bet kokius papildomus vaistus pasitarti su savo gydytoju, vengti didelio streso [10].…”