Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle

Davison, H. C.; Otter, A.; Trees, A. J.

doi:10.1016/s0020-7519(99)00129-0

Cited by 225 publications

(144 citation statements)

References 20 publications

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“…In a previous study of three herds with N. caninum abortion rates of 23-43%, we found a transplacental transmission of approximately 45% in postnatally infected animals (Dijkstra et al, 2006). These figures are lower than the rates varying from 81 to 95% reported in some studies (Paré et al, 1996(Paré et al, , 1997Schares et al, 1998;Wouda et al, 1998b;Davison et al, 1999), but in the same range as in other studies in herds with postnatally infected cattle: 56% (Mainar-Jaime et al, 1999), 44% (Bergeron et al, 2000), 39.3% (Dyer et al, 2000) and 63.7% (Romero and Frankena, 2003). We suggest that TPI may be more likely to occur in dams that were themselves prenatally infected compared with postnatally infected dams.…”

Section: Discussioncontrasting

confidence: 56%

Natural postnatal Neospora caninum infection in cattle can persist and lead to endogenous transplacental infection

Dijkstra

Lam

Bartels

et al. 2008

Veterinary Parasitology

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A serological follow-up study of 3.5 years duration was done of a dairy herd that had experienced a mass seroconversion to Neospora caninum following a point source exposure shortly before the 17th of January 2000. A total of 913 blood samples of 244 animals at seven sampling dates were used to investigate the seroprevalence dynamics in the herd.Most postnatally infected cattle remained seropositive during the period of investigation but 11 animals became seronegative after 6-27 months indicating transient infection. Six animals seroconverted later than the main group of 45 animals and 5 animals became seronegative after at least two seropositive records possibly due to a low infection dose or difference in the haplotypes of the infected animals. In total 58% (14/24) of the offspring of postnatally infected dams was seropositive. Nine of 16 (56%) daughters originating from inseminations after the postnatal infection of their dams were seropositive indicating endogenous transplacental infection. #

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Section: Discussioncontrasting

confidence: 56%

Natural postnatal Neospora caninum infection in cattle can persist and lead to endogenous transplacental infection

Dijkstra

Lam

Bartels

et al. 2008

Veterinary Parasitology

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“…Otra posibilidad sería la introducción de animales seropositivos. En un estudio del Reino Unido se demostró que la trasmisión vertical fue del 95.2%; es decir, vacas seropositivas tienen mayor probabilidad de producir terneros infectados (Davison et al, 1999); condición que conlleva a perpetuar la infección en el hato. …”

Section: Muestrasunclassified

SEROPREVALENCIA DE Neospora caninum EN BOVINOS LECHEROS DEL VALLE DE LIMA.

Chávez

et al. 2014

Rev. investig. vet. Perú

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El objetivo del presente estudio fue determinar la seroprevalencia de Neospora caninum en bovinos lecheros del valle de Lima en el año 2000. Se evaluaron 304 sueros de vacas lecheras adultas provenientes de 19 establos lecheros ubicados en la zona norte (n = 12) y en la zona sur (n = 7) del valle de Lima, para detectar anticuerpos contra N. caninum mediante la prueba de inmunofluorescencia indirecta. El 29.

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“…Cattle are generally infected prenatally by transplacental infection from persistently infected dams [5,6]. Other possible postnatal sources of vertical transmission, such as colostrum or milk, have not yet been confirmed in naturally-infected cattle [7].…”

Section: Introductionmentioning

confidence: 99%

“…Other possible postnatal sources of vertical transmission, such as colostrum or milk, have not yet been confirmed in naturally-infected cattle [7]. Epidemiological evidence also suggests horizontal transmission [6,8]. Calves [9] and pregnant cows [10] can be experimentally infected by oral administration of Neospora oocyst shed by dogs, and the N. caninum life cycle has been reproduced by cyclical oral transmission between dogs and cattle [11].…”

Section: Introductionmentioning

confidence: 99%

Intrauterine Neospora caninum inoculation of heifers and cows using contaminated semen with different numbers of tachyzoites

et al. 2007

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Objective: To investigate the potential of different Neospora caninum tachyzoite doses to infect heifers (experiment 1) and cows (experiment 2) when administered in utero by artificial insemination via contaminated semen. Methods: In experiment 1, five groups of 5, 7, 8, 9, and 5 cyclic heifers were hormonally synchronized and artificially inseminated with semen containing 0 (A, controls), 10 2 (B), 5 Â 10 3 (C), 5 Â 10 4 (D), and 5 Â 10 5 (E) live N. caninum NC-1 isolate-tachyzoites, respectively. Experimental infection was followed for 100 days. Parasitaemia and specific serum IgG, and interferon-gamma (IFNg) responses were studied. In experiment 2, four groups of 9, 10, 9, and 9 adult multiparous cows with confirmed infertility problems of diverse aethiology were hormonally synchronized and artificially inseminated with semen containing 0 (a, controls), 10 2 (b), 5 Â 10 3 (c), and 5 Â 10 5 (d) live N. caninum NC-1 isolate-tachyzoites, respectively. Experimental infection was followed for 63 days. Parasitaemia and specific serum IgG responses were studied. Results: In experiment 1, parasitaemia was detected in 1, 2, and 3 heifers from groups B, C, and D, respectively, between 9 and 23 days after insemination. Persistent specific serum antibody responses were detected in 2 and 3 heifers from groups D and E, respectively. Transient specific serum antibody responses were detected in 2, 1 and 1 heifers from groups C, D, and E, respectively. In addition, 1 heifer from group B showed a serum-specific antibody level higher than cut off value at 21 days post-insemination. Heifers seroconverted between 23 and 47 days after insemination. Specific IFN-g levels were detected in 1, 4, 6, and 3 heifers from groups B, C, D, and E, respectively, between 9 and 55 days after insemination. Pregnancy rate in the control group (60%) was higher than those observed in inoculated heifers (0-42.9%). Pregnancy rates in inoculated heifers were lower when the tachyzoite dose was increased (B 42.9%, C 12.5%, D 11.1%, and E 0%). In experiment 2, no Neospora DNA in blood nor specific serum IgG to N. caninum were detected in any of the cows studied, except in one cow inoculated with 5 Â 10 5 tachyzoites (group d) which showed a relative index Â 100 (RIPC) values of 9.4, 18.9, and 18.1 at 42, 56, and 63 days after insemination, respectively. Conclusions: This study provides evidence that the intrauterine infection via contaminated semen using 5 Â 10 4 and 5 Â 10 5 tachyzoites caused persistent serum-specific antibody responses in some heifers. On the basis of serological data, a dose-response

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Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle

Cited by 225 publications

References 20 publications

Natural postnatal Neospora caninum infection in cattle can persist and lead to endogenous transplacental infection

Natural postnatal Neospora caninum infection in cattle can persist and lead to endogenous transplacental infection

SEROPREVALENCIA DE Neospora caninum EN BOVINOS LECHEROS DEL VALLE DE LIMA.

Intrauterine Neospora caninum inoculation of heifers and cows using contaminated semen with different numbers of tachyzoites

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