Estimation of TNF-&amp;alpha; Levels in Saliva and Serum of Patients with Periodontal Health and Chronic Periodontitis: A Case-control Study

Alamelu, Swarna; Kadhiresan, R; Ulaganathan, Arunmozhi; Shanmugapriya, R.; Ganesan, Rathinavelu; Saket, Parthiban

doi:10.5005/jp-journals-10024-2765

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…TNF‐α is a key inflammatory cytokine in the pathological process of periodontitis 29 . It has the effect of initiating and amplifying the inflammatory response and plays an important role in the destruction of periodontal tissue 30,31 (Figure 4H). Moreover, TNF‐α and IL‐1β can promote the expression of RANKL and participate in the bone loss of ligature‐induced periodontitis 29 .…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF‐κB pathway

Chen

Liu

et al. 2023

J of Periodontal Research

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Periodontitis is caused by the dynamic imbalance between microbial virulence factors and host defense. The chronic inflammation of periodontitis leads to the formation of periodontal pockets, progressive loss of soft tissue attachment, and alveolar bone resorption, which can eventually lead to tooth loosening and loss. [1][2][3][4] Hence, anti-inflammatory is of great significance for periodontal treatment.Cannabis, as an ancient medicinal plant, has important agricultural and medicinal values. 5,6 Cannabidiol (CBD) is a non-addictive component in cannabis and has been used to treat epilepsy, cancer, chronic pain, and immune diseases. [7][8][9][10] Moreover, existing research

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Section: Discussionmentioning

confidence: 99%

Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF‐κB pathway

Chen

Liu

et al. 2023

J of Periodontal Research

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“…Increases in TNF-α concentrations have been reported after nonsurgical periodontal treatment, with higher levels in healthy subjects than in unhealthy patients [7] 50. According to Kadhiresan Rathinasamy et al, [37]patients with generalized chronic periodontitis, which was a common disease, were taken as the study group. Although the results yielded were not statistically significant, to promote the use of TNF-α as serum and salivary biomarkers in predicting the risk of development of systemic disease such as diabetes mellitus.…”

Section: Resultsmentioning

confidence: 99%

“…According to Teles et al, [37,38] when chronic periodontitis patients within an age range of 17-30 years were assessed for their salivary level of TNF-α, the periodontitis patients showed a higher level when compared with the control group, and the slight difference in the results was attributed to reasons such as different age groups, limited study samples, and dissimilar sampling and evaluation techniques.…”

Section: Resultsmentioning

confidence: 99%

Measurement of Salivary Tumor Necrosis Factor- alpha (TNF- α) in Periodontitis Patients with or without Diabetes Mellitus

Swetaa

Jeevitha

Jayaraman

2021

JPRI

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Introduction: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory mediator considered to be a soluble mediator released from immunocompetent cells. It exercises a wide range of proinflammatory and immunomodulatory effects in different cell populations, such as stimulating prostaglandin synthesis, promoting tumors in a variety of cancers, producing proteases, and activating osteoclastic function and therefore bone resorption. Its myriad functions suggest that TNF-α plays an important role in mediating the immune-inflammatory responses initiated by infection or other types of damage. Aim: The aim of the present study is to evaluate the concentrations of Tumour Necrosis Factor- alpha (TNF- α) in the saliva of periodontitis patients with or without diabetes mellitus. Materials and methods: A total of 30 participants were taken and divided into 3 groups with each group consisting of 10 saliva samples from patients with clinically healthy gingiva and patients with chronic periodontitis with diabetes mellitus and periodontitis patients only. Saliva sample was collected and salivary TNF- α was done using Enzyme Linked Immunosorbent Assay (ELISA). Statistically analyses was done by one way ANOVA test Results: Salivary TNF- α concentration in periodontal health, periodontitis with diabetes mellitus (P+DM), Periodontitis only (P) were analysed. Salivary TNF- α concentration was found to be significantly higher (p<0.05) in periodontitis with diabetes mellitus (49±3.5 pg/ml) when compared with periodontitis only (29±3.6 pg/ml) and also when compared with healthy controls (17±1.4 pg/ml). Conclusion: The present study showed elevated TNF- α in periodontitis patients with diabetes mellitus when compared to patients with periodontitis only and normal healthy patients. Further studies are required in a large scale to substantiate the role of TNF-α in the progression of periodontal diseases.

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“…Nuclear factor-kappa B (NF-κB) is a transcription factor involved in the regulation of proteins belonging to the Bcl-2 family and a key regulator of the expression of proteins in the immune system that can be induced by TNF cytokines [ 52 , 53 ]. Upon infection, TNF-α levels are increased both in serum and saliva, indicating an active state of immune responsiveness [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis

Prucsi,

Zimny,

Płonczyńska

et al. 2023

IJMS

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Periodontitis is a widespread chronic inflammatory disease caused by a changed dysbiotic oral microbiome. Although multiple species and risk factors are associated with periodontitis, Porphyromonas gingivalis has been identified as a keystone pathogen. The immune-modulatory function of P. gingivalis is well characterized, but the mechanism by which this bacterium secretes peptidyl arginine deiminase (PPAD), a protein/peptide citrullinating enzyme, thus contributing to the infinite feed-forward loop of inflammation, is not fully understood. To determine the functional role of citrullination in periodontitis, neutrophils were stimulated by P. gingivalis bearing wild-type PPAD and by a PPAD mutant strain lacking an active enzyme. Flow cytometry showed that PPAD contributed to prolonged neutrophil survival upon bacterial stimulation, accompanied by the secretion of aberrant IL-6 and TNF-α. To further assess the complex mechanism by which citrullination sustains a chronic inflammatory state, the ROS production and phagocytic activity of neutrophils were evaluated. Flow cytometry and colony formation assays showed that PPAD obstructs the resolution of inflammation by promoting neutrophil survival and the release of pro-inflammatory cytokines, while enhancing the resilience of the bacteria to phagocytosis.

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Estimation of TNF-α Levels in Saliva and Serum of Patients with Periodontal Health and Chronic Periodontitis: A Case-control Study

Cited by 11 publications

References 12 publications

Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF‐κB pathway

Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF‐κB pathway

Measurement of Salivary Tumor Necrosis Factor- alpha (TNF- α) in Periodontitis Patients with or without Diabetes Mellitus

Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis

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