Estimation of time since death from CSF electrolyte concentration in Bhopal region of central India

Yadav, Jayanthi; Deshpande, Aashish; Arora, Atul; Athawal, B.K.; Dubey, Bhawna

doi:10.1016/j.legalmed.2007.05.001

Cited by 17 publications

(8 citation statements)

References 13 publications

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“…Mason et al [14] was the first to find a significant relationship between PMI and potassium levels in cisternal CSF. Many studies have since reported a similar trend [3,13,[15][16][17][18][19][20][21][22]. Urban et al even showed a strong linear correlation between the estimated TSD from cisternal potassium concentration and the estimated TSD based on rectal temperature by using the nomogram method of Henssge [1].…”

Section: Electrolytes a Potassiummentioning

confidence: 89%

“…Others similarly found a non-significant decrease of sodium with PMI in post-mortem CSF samples [15,20]. More recently, studies showed a statistically significant negative correlation between sodium levels and PMI up to 20-25 h after A c c e p t e d M a n u s c r i p t death [1,3,13,21], although the ratio of sodium and potassium concentrations may remain a better parameter for PMI estimation compared to ion values alone [13].…”

Section: B Sodiummentioning

confidence: 99%

“…Emphasis has been placed on the study of concentration changes of chemicals in closed compartment body fluids, as they are neither altered nor contaminated as quickly as blood after death. Because of their isolated and confined topography, autolysis proceeds more slowly in these fluids than in blood [3,12,13]. VH has been the most extensively studied fluid compartment.…”

Section: Introductionmentioning

confidence: 99%

“…Criteria used for selecting participants greatly differ from one study to another, which makes inter-comparison of results obtained for the same biomarker difficult.For example, some studies have included patients with CNS diseases or trauma[32,46,50] while others have not[3,13,20,52]. This may greatly affect the results as the post-mortem levels of intracellular biomarkers in the CSF from patients with CNS disorders (such as neurodegenerative disease, stroke or infection) or traumatic brain injury may be subject to an increase due to substantial brain cell death.…”

mentioning

confidence: 99%

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Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Peyron

Lehmann

Delaby

et al. 2019

Critical Reviews in Clinical Laboratory Sciences

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Biochemical markers of time since death in cerebrospinal fluid: a first step towards "Forensomics" The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the post-mortem interval (PMI) are far from being precise. Over the past decades, biochemical methods have been implemented on post-mortem samples to improve the precision of PMI estimation. Studies have focussed on the biochemical profiles of closed compartment body fluids, as they are preserved longer than blood after death and are thus subject to confined post-mortem chemical changes. Cerebrospinal fluid (CSF) has been considered a suitable fluid to investigate these changes, as it is found in large amounts and is easy to sample. Moreover, the main molecules found in CSF have known reference values in living subjects, unlike most other body fluids. In this literature review, we focus on the panel of biomarkers that have been studied in CSF based on their potential of offering information on the time of death. The interest of these biomarkers in casework and the research perspectives in this field are discussed. Integrating data from different methods, including biochemistry, for better estimation of the time of death would represent a step forward in the forensic field, paving the way for an innovative approach that we suggest to call "Forensomics".

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Section: Electrolytes a Potassiummentioning

confidence: 89%

Section: B Sodiummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Peyron

Lehmann

Delaby

et al. 2019

Critical Reviews in Clinical Laboratory Sciences

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show abstract

“…Thus, death time estimation using supravital reactions is considered useful and valuable from a theoretical viewpoint although rarely evaluated in everyday forensic practice. The reason is that most of these techniques, as well as new methods based on biochemical markers or other parameters [28][29][30][31][32][33], require some type of biopsy or collected biological fluids and laboratory tests. Moreover, there is the possibility of altering the crime scene.…”

Section: Discussionmentioning

confidence: 99%

Nasal ciliary motility: a new tool in estimating the time of death

et al. 2012

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Determination of time since death is one of the most difficult and crucial issue in forensic medicine. Apart from body cooling, which is commonly used in the early postmortem interval (PMI), supravital reactions are the most interesting postmortem changes for time of death estimation. Nasal ciliary motility has been occasionally observed in postmortem period although no studies have focused on this phenomenon for forensic purposes. We aimed to evaluate the diagnostic usefulness of ciliary motility as a potential tool in estimating the time of death. Specimens of ciliated epithelium from 100 consecutive cadavers were obtained by scraping the nasal mucosa at three different postmortem intervals. The samples were then smeared on a slide, and an in vitro evaluation of ciliary movement was analyzed by phase-contrast microscopy. A postmortem nasal ciliary motility was observed, and a statistically significant relationship between decreasing ciliary movements and increasing postmortem interval was detected even in presence of putrefactive changes of nasal ultrastructure integrity. Some peculiar causes of death seem to influence ciliary motility in the early PMI, while no significant correlations with sex or age were observed. According to the results of this study, postmortem evaluation of nasal ciliary motility may be a bona fide and a feasible option for estimating the time of death.

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Molecular characterization of gut microbial shift in SD rats after death for 30 days

Yang

Zhang

et al. 2020

Arch Microbiol

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Estimation of time since death from CSF electrolyte concentration in Bhopal region of central India

Cited by 17 publications

References 13 publications

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Nasal ciliary motility: a new tool in estimating the time of death

Molecular characterization of gut microbial shift in SD rats after death for 30 days

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