Estimation of the skull insertion loss using an optoacoustic point source

Estrada, Héctor; Rebling, Johannes; Turner, Jake; Kneipp, Moritz; Shoham, Sharon; Razansky, Daniel

doi:10.1117/12.2211183

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Kneipp et al were the first to study different acoustic distortions induced by murine skulls and their impacts on PAM images . Later, Estrada et al employed a photoacoustic point source to estimate the skull's insertion loss and studied the acoustic wave propagation in both human and mouse skulls . Mohammadi et al theoretically analyzed the acoustic attenuation and dispersion induced by the skull with a simplified two‐layer skull model.…”

Section: Introductionmentioning

confidence: 99%

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Liang

Liu

Zhan

et al. 2019

Journal of Biophotonics

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Non‐invasive photoacoustic tomography (PAT) of mouse brains with intact skulls has been a challenge due to the skull's strong acoustic attenuation, aberration, and reverberation, especially in the high‐frequency range (>15 MHz). In this paper, we systematically investigated the impacts of the murine skull on the photoacoustic wave propagation and on the PAT image reconstruction. We studied the photoacoustic acoustic wave aberration due to the acoustic impedance mismatch at the skull boundaries and the mode conversion between the longitudinal wave and shear wave. The wave's reverberation within the skull was investigated for both longitudinal and shear modes. In the inverse process, we reconstructed the transcranial photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM) images of a point target enclosed by the mouse skull, showing the skull's different impacts on both modalities. Finally, we experimentally validated the simulations by imaging an in vitro mouse skull phantom using representative transcranial PAM and PACT systems. The experimental results agreed well with the simulations and confirmed the accuracy of our forward and inverse models. We expect that our results will provide better understanding of the impacts of the murine skull on transcranial photoacoustic brain imaging and pave the ways for future technical improvements.

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Section: Introductionmentioning

confidence: 99%

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Liang

Liu

Zhan

et al. 2019

Journal of Biophotonics

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“…This enhancement in the quality of the reconstruction was achieved without introducing distortions to the upper part of the image which was not well covered by the detection geometry. Such enhancement can further facilitate preclinical OA investigation of the brain activity through the intact skull, which is a main challenge in in vivo transcranial imaging [36].…”

Section: Discussionmentioning

confidence: 99%

Weighted model‐based optoacoustic reconstruction for partial‐view geometries

Muhammad

Prakash

Liapis

et al. 2022

Journal of Biophotonics

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Acoustic heterogeneities in biological samples are known to cause artifacts in tomographic optoacoustic (photoacoustic) image reconstruction. A statistical weighted model‐based reconstruction approach was previously introduced to mitigate such artifacts. However, this approach does not reliably provide high‐quality reconstructions for partial‐view imaging systems, which are common in preclinical and clinical optoacoustics. In this article, the capability of the weighted model‐based algorithm is extended to generate optoacoustic reconstructions with less distortions for partial‐view geometry data. This is achieved by manipulating the weighting scheme based on the detector geometry. Using partial‐view optoacoustic tomography data from a tissue‐mimicking phantom containing a strong acoustic reflector, tumors grafted onto mice, and a mouse brain with intact skull, the proposed partial‐view‐corrected weighted model‐based algorithm is shown to mitigate reflection artifacts in reconstructed images without distorting structures or boundaries, compared with both conventional model‐based and the weighted model‐based algorithms. It is also demonstrated that the partial‐view‐corrected weighted model‐based algorithm has the additional advantage of suppressing streaking artifacts due to the partial‐view geometry itself in the presence of a very strong optoacoustic chromophore. Due to its enhanced performance, the partial‐view‐corrected weighted model‐based algorithm may prove useful for improving the quality of partial‐view multispectral optoacoustic tomography, leading to enhanced visualization of functional parameters such as tissue oxygenation.

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“…Compared to the common 1 MHz ultrasound 40,41 , a key limitation of the 30 MHz ultrasound is that it will suffer from stronger loss through thick skulls (e.g. human skull) 5,[42][43][44] . Therefore, it may not be able to achieve noninvasive transcranial performance on the human brain [45][46][47] .…”

Section: Discussionmentioning

confidence: 99%

High resolution ultrasonic neural modulation observed viain vivotwo-photon calcium imaging

Cheng

Wang

Bian

et al. 2021

Preprint

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Neural modulation plays a major role in delineating the circuit mechanisms and serves as the cornerstone of neural interface technologies. Among the various modulation mechanisms, ultrasound enables noninvasive label-free deep access to mammalian brain tissue. To date, most if not all ultrasonic neural modulation implementations are based on ~1 MHz carrier frequency. The long acoustic wavelength results in a spatially coarse modulation zone, often spanning over multiple function regions. The modulation of one brain region is inevitably linked with the modulation of its neighboring regions. To significantly increase the spatial resolution, we explored the application of high-frequency ultrasound. To investigate the neuronal response at cellular resolutions, we developed a dual-modality system combining in vivo two-photon calcium imaging and focused ultrasound modulation. The studies show that the ~30 MHz ultrasound can suppress the neuronal activity in awake mice at 100-micron scale spatial resolutions, paving the way for high-resolution ultrasonic neural modulation.

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Estimation of the skull insertion loss using an optoacoustic point source

Cited by 3 publications

References 8 publications

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Weighted model‐based optoacoustic reconstruction for partial‐view geometries

High resolution ultrasonic neural modulation observed viain vivotwo-photon calcium imaging

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