Estimation of the Relative Amount of Hemoglobin in the Cup and Neuroretinal Rim Using Stereoscopic Color Fundus Images

Pena-Betancor, Cristina; González-Hernández, Marta; Fumero-Batista, Francisco; Sigut, J.; Medina-Mesa, Erica; Alayón, Silvia; Rosa, Manuel González de la

doi:10.1167/iovs.14-15592

Cited by 37 publications

(57 citation statements)

References 26 publications

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“…Several studies examined the agreement between subjective and objective VCDR assessment [5,[11][12][13][14][15] . In general, the value obtained from objective measurement is smaller than the clinically assessed VCDR, but some found the opposite to be true [13] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, stereo photographs can be of help to assess disc morphology and stored for future reference [10] . These photos can be assessed by the clinician or analysed by specifically designed software [11] . The relationship and agreement between a clinical subjective (funduscopic) and technological objective assessment were investigated in multiple studies [5,[12][13][14][15][16] .…”

Section: Funduscopic Versus Hrt III Confocal Scannermentioning

confidence: 99%

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Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study)

Willekens

Bataillie²,

Sarens³

et al. 2016

Ophthalmic Res

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Purpose: To compare funduscopic and confocal scanning vertical cup-disc ratio (VCDR) assessments and their respective predictive value for estimating functional glaucomatous damage. Methods: Data from a single eye of open angle glaucoma patients from the Leuven Eye Study were included: age, gender, intra-ocular pressure, visual acuity, refractive error, visual field mean deviation and pattern standard deviation, funduscopic and HRT III VCDRs as well as mean retinal nerve fibre layer thickness. Non-parametric tests to compare differences within and between diagnostic groups were used, and receiver-operating characteristic curves as well as Bland-Altman plots constructed. Results: Three hundred and one eyes of 301 subjects with primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) were included. The average VCDR assessed with HRT III was significantly smaller than the funduscopic measurement (0.69 ± 0.16 vs. 0.81 ± 0.14, respectively; p < 0.001). The predictive value of both measurement techniques did not differ in NTG patients, but the funduscopic estimate yielded a significantly larger predictive power in patients with severe POAG. Conclusion: Funduscopic and confocal scanner estimates of VCDR differ significantly and should not be used interchangeably. In POAG patients with severe glaucoma, a subjective VCDR predicts functional glaucomatous damage significantly better.

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Section: Discussionmentioning

confidence: 99%

Section: Funduscopic Versus Hrt III Confocal Scannermentioning

confidence: 99%

Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study)

Willekens

Bataillie²,

Sarens³

et al. 2016

Ophthalmic Res

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“…No special importance was attached to equating the samples by age, since previous studies have shown no significant changes with age in the hemoglobin values of the ONH in normal subjects [11]. …”

Section: Methodsmentioning

confidence: 99%

“…New studies have allowed separating the rim from cup information, analyzing images obtained with a stereoscopic camera [11], and also associating two-dimensional photographic images with optical disk and cup delimitations provided by OCT [12]. Among the conclusions of these studies, two stand out: first, hemoglobin concentrations are better correlated with functional defects of glaucoma than the corresponding areas of the neuroretinal rim or RNFL thicknesses.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

González-Hernández

Sigut

Rosa

2017

Journal of Ophthalmology

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Purpose To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R = 0.81 (P < 0.0001), similar to that between the BMO-MRW and BMO-RNFL thicknesses (R = 0.85, P < 0.0001) (P = 0.227 between both R values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.

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“…As an example of such a technique, 3D reconstruction of the Optic Nerve Head (ONH) in the retina can be mentioned. Figure 7 shows two examples of such an application by use of dense SIFT descriptors using the data provided as part of [65]. For each one of these examples, a pair of input images acquired from the left and right views of the ONH (first and second column) is captured, and the approximate depth information is retrieved (third column).…”

Section: Applications In Biomedical Image Processingmentioning

confidence: 99%

Dense Descriptors for Optical Flow Estimation: A Comparative Study

Baghaie

D’Souza

2017

J. Imaging

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Estimating the displacements of intensity patterns between sequential frames is a very well-studied problem, which is usually referred to as optical flow estimation. The first assumption among many of the methods in the field is the brightness constancy during movements of pixels between frames. This assumption is proven to be not true in general, and therefore, the use of photometric invariant constraints has been studied in the past. One other solution can be sought by use of structural descriptors rather than pixels for estimating the optical flow. Unlike sparse feature detection/description techniques and since the problem of optical flow estimation tries to find a dense flow field, a dense structural representation of individual pixels and their neighbors is computed and then used for matching and optical flow estimation. Here, a comparative study is carried out by extending the framework of SIFT-flow to include more dense descriptors, and comprehensive comparisons are given. Overall, the work can be considered as a baseline for stimulating more interest in the use of dense descriptors for optical flow estimation.

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Estimation of the Relative Amount of Hemoglobin in the Cup and Neuroretinal Rim Using Stereoscopic Color Fundus Images

Abstract: Visual field sensitivity was better correlated with Hb levels than with rim sector areas or the corresponding nerve fiber thickness. In many cases the remaining rim show low perfusion, especially in the superior and inferior sectors.

Cited by 37 publications

References 26 publications

Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study)

Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study)

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

Dense Descriptors for Optical Flow Estimation: A Comparative Study

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