Estimation of the following Cardiac Output Using Sympathetic Tone and Hemodynamics for the Control of a Total Artificial Heart

Yambe, Tomoyuki; Nitta, Shin Ichi; Katahira, Yoshiaki; Sonobe, Taro; Naganuma, S.; Akiho, H.; Kakinuma, Y.; Izutzu, K; Kikuchi, Yoshiyuki; Naganuma, Takako

doi:10.1177/039139889201501007

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…In this study, the functional formula for an accurate estimate of the following cardiac output was designed, and the possibility of a real-time automatic TAR control system was analyzed [13]. Seven adult mongrel dogs of both sexes weighing 15-35kg were anesthetized with thiopental sodium (2.5 mg/kg) and intravenous ketamine sodium (5.0 mg/kg).…”

Section: Prediction With Information About Sympathetic Nerve Dischargesmentioning

confidence: 99%

“…A variety of TAH control methods have been evaluated in various laboratories [13,14]. Many investigators have used a control algorithm based on Starling's law and others have proposed a control method in which AoP is maintained as a constant value [15].…”

Section: Future Prediction By An Autonomic Nerve and Hemodynamicsmentioning

confidence: 99%

“…A control algorithm for the TAH has been discussed more and more from various viewpoints [13][14][15]. Several investigators have proposed an automatic TAH control algorithm to prevent thrombus formation and suggested the importance of full stroke driving [14,15].…”

Section: Mayer Wave Control For An Artificial Heartmentioning

confidence: 99%

“…In view of the widespread clinical application of TAHs such as their bridge use for transplantation, the importance of quality of life (QOL) for a patient with an artificial heart attracts attention as a next step in development [13,15]. Various cardiac outputs are needed during various activities [11].…”

Section: Mayer Wave Control For An Artificial Heartmentioning

confidence: 99%

See 3 more Smart Citations

Searching for the Origin of Chaos

Yambe¹,

Yoshizawa²,

Tabayashi³

et al. 2009

Nonlinear Biomedical Signal Processing, Dynamic Analysis and Modeling

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The clinical significance of chaotic dynamics in the cardiovascular system has attracted attention. The circulatory system is a kind of complex system having many feedback circuits, so it has been difficult to investigate the origin of chaos in the circulatory system. In this study, we investigated the origin of chaos by using the methodology of open-loop analysis with an artificial heart, which did not have any fluctuation in its own pumping rate and contraction power, in chronic animal experiments using healthy adult goats. In the circulatory time series data of the artificial heart, which did not have any fluctuation, low-dimensional deterministic chaos was discovered by nonlinear mathematical analysis, suggesting the importance of the blood vessel system in the chaotic dynamics of the cardiovascular system. To investigate the origin of chaos further, sympathetic nerve activity was directly measured in the animal experiments with artificial heart circulation. Chaotic dynamics was also recognized in the sympathetic nerve action potentials, even during artificial heart circulation, suggesting the importance of a central nervous system. In the next step, in order to generate chaotic dynamics in the circulation, an electrical simulation model of left heart circulation with a feedback loop with some delay was tested, and we found that we can make chaos in the circulation by a feedback loop. Thus, we constituted an artificial baroreflex system with an artificial heart system and found that we could introduce chaos in an animal model. Finally, we proposed clinical application of these methodologies for the diagnosis of an autonomic nervous system and found that it may be useful. These findings may be useful for analyzing the nonlinear dynamics in the circulation.

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Section: Prediction With Information About Sympathetic Nerve Dischargesmentioning

confidence: 99%

Section: Future Prediction By An Autonomic Nerve and Hemodynamicsmentioning

confidence: 99%

Section: Mayer Wave Control For An Artificial Heartmentioning

confidence: 99%

Section: Mayer Wave Control For An Artificial Heartmentioning

confidence: 99%

See 2 more Smart Citations

Searching for the Origin of Chaos

Yambe¹,

Yoshizawa²,

Tabayashi³

et al. 2009

Nonlinear Biomedical Signal Processing, Dynamic Analysis and Modeling

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show abstract

“…Various control methods for an artificial heart have been attempted worldwide (1)(2)(3)(4)(5). First, we must achieve automatic control for the artificial heart itself (2).…”

mentioning

confidence: 99%

A Future Prediction Type Artificial Heart System

Yambe

Tanizuka²,

Yoshizawa

et al. 1999

Artificial Organs

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The demand of the biological system needs to be predicted to consider the quality of life (QOL) of a patient with an artificial heart system. The purpose of this study was the prediction of the imminent cardiac output and the predictive control for an artificial heart. For that purpose, autonomic nerve information was applied in this study. Nervous sympathicus action potentials were measured, and a prediction function of cardiac output was made using the sympathetic tone and preload and after-load measurement with multiple regression analysis. The predicted value showed significant correlation with the measured value after 2.9 s. Currently, however, long-term instrumentation of the nervous sympathicus potential is difficult. Thus, hemodynamic fluctuations, which recently have attracted attention, were used in this study. A prediction function using the Mayer wave, which represented nervous sympathicus, was determined. As a result, mid-term prediction became possible. Furthermore, a measurement of the vagal nerve was used as a possible long-term prediction parameter. For long-term prediction, Hurst exponent analysis was used in this study. Vagal nerve discharges in the changing position showed alteration of long-term determination. In conclusion, the future prediction control of an artificial heart takes shape using these prediction functions.

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Autonomic nerve function with an artificial heart and ventricular assist device

et al. 2001

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Although the autonomic nervous system is important for the quality of life of patients with an artificial heart, there has been little research in this field. Long ago, Atsumi et al. studied the artificial heart syndrome and the autonomic nerve. Kojima and Nose reported on the RP rotary pump and hemodynamic fluctuations. Direct recording of autonomic nerve discharges in an animal with an artificial heart had begun in the autonomic nerve activities record of the mechanical heart and succeeded in Tohoku. The autonomic nervous system function attracts attention all the more in RP as well in the clinical beginning. We summarize recent autonomic nerve research.

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Estimation of the following Cardiac Output Using Sympathetic Tone and Hemodynamics for the Control of a Total Artificial Heart

Cited by 11 publications

References 11 publications

Searching for the Origin of Chaos

Searching for the Origin of Chaos

A Future Prediction Type Artificial Heart System

Autonomic nerve function with an artificial heart and ventricular assist device

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