Estimation of the EEG power spectrum using MRI T2 relaxation time in traumatic brain injury

Clinical electrophysiologic assessments and mild traumatic brain injury: State-of-the-science and implications for clinical practice

“…In a related study (Thatcher et al, 1998a), white matter T2 relaxation times correlated positively with increased delta amplitude whereas gray matter T2 relaxation time were inversely correlated with alpha and beta amplitude. Thatcher et al (2001a) also observed relationships between T2 relaxation times and both alpha and delta-theta (0.5-5 Hz) power. These qEEG-MRI abnormalities were associated with relatively poorer neuropsychological test performance, and interpreted as reflecting reduced integrity of the protein/lipid neural membranes and diminished efficiency of neural systems following mTBI.…”

“…The subjects in these qEEG-MRI studies were heterogeneous with respect to TBI severity (mild to severe), time since injury (six days to 11 years), and stage of postinjury rehabilitation. In two of these studies (Thatcher et al, 1998b(Thatcher et al, , 2001a, qEEG and MRI data from Veterans with TBI were compared against those of normal high school students. In both of these studies, there were unacknowledged and statistically unaccounted-for between-group age differences: in Thatcher et al (2001a), t = 5.1, p b .0001 for TBI vs. controls; in Thatcher et al (1998b), t = 5.4, p b .0001 for TBI Group 1 vs. controls and t = 4.4, p b .0001 for TBI Group 2 vs. controls; and in Thatcher et al (1998b), there also was an age difference between the two TBI groups studied (t = 2.5, p b .02).…”

“…In two of these studies (Thatcher et al, 1998b(Thatcher et al, , 2001a, qEEG and MRI data from Veterans with TBI were compared against those of normal high school students. In both of these studies, there were unacknowledged and statistically unaccounted-for between-group age differences: in Thatcher et al (2001a), t = 5.1, p b .0001 for TBI vs. controls; in Thatcher et al (1998b), t = 5.4, p b .0001 for TBI Group 1 vs. controls and t = 4.4, p b .0001 for TBI Group 2 vs. controls; and in Thatcher et al (1998b), there also was an age difference between the two TBI groups studied (t = 2.5, p b .02). In addition to the statistical concerns raised by these differences, comparing qEEG-MRI (and, especially, white matter data) from adult subjects with TBI to adolescent control subjects -among who incomplete cerebral development (Paus, 2010;Schmithorst and Yuan, 2010;White et al, 2010) alone might contribute substantively to the observed differences in qEEG patterns and qEEG-MRI correlationswithout controlling for the effects of or interactions with age introduces a potentially serious confound on interpretation of data derived from these studies.…”

Treating Thought Disorders

“…186,187 The importance of proper location and frequency band selection was also shown by Moore in a review of two OCD studies he conducted, where he found that pure alpha training did not produce any results. He concluded that this was because there were two OCD subgroups, neither of which would have been expected to benefit from alpha training.…”

Brain magnetic resonance elastography on healthy volunteers: A safety study

“…This could be caused by vibration or a complex action of vibration and the MRE sequence scan. THATCHER et al (22) evaluated the validity and sensitivity of EEG in detecting both functional and structural damage in concussed subjects, and the severity of injury. Specifically, damage to gray matter did not only reduce local excitation but, most importantly, reduced synchronization of the active generators, which in turn resulted in reduced EEG amplitude.…”