Abstract:Recently, AI has been used in industry for very precise quality control of various products or in the automation of production processes through the use of trained artificial neural networks (ANNs) which allow us to completely replace a human in often tedious work or in hard-to-reach locations. Although the search for analytical formulas is often desirable and leads to accurate descriptions of various phenomena, when the problem is very complex or when it is impossible to obtain a complete set of data, methods… Show more
Otilionium bromide (OB) is a quaternary ammonium compound which is commonly known in pharmaceutical industry. It affects the distal gastrointestinal tract as an antispasmodic agent which is used by patients with irritable bowel syndrome (IBS). The drug's action is based on the inhibition of L-type and T-type calcium channels. Around 15% of the Western population struggles with IBS. OB is characterized by weak systematic absorption, which may prevent other negative impact on organism. There have been several successful treatments worldwide using OB and placebo. These medical trials have proven to be safe and successful in patients with irritable bowel syndrome. The medication reduces abdominal pain, boiling sensation and relieves discomfort better than placebo. The effects of using OB are longlasing, even after dosing is stopped. Studies have shown that treatment with OB bromide improves quality of life. This article describes the mechanism of action, synthesis, pharmacological effects of OB and aspects in which OB improves a person's quality of life.
Otilionium bromide (OB) is a quaternary ammonium compound which is commonly known in pharmaceutical industry. It affects the distal gastrointestinal tract as an antispasmodic agent which is used by patients with irritable bowel syndrome (IBS). The drug's action is based on the inhibition of L-type and T-type calcium channels. Around 15% of the Western population struggles with IBS. OB is characterized by weak systematic absorption, which may prevent other negative impact on organism. There have been several successful treatments worldwide using OB and placebo. These medical trials have proven to be safe and successful in patients with irritable bowel syndrome. The medication reduces abdominal pain, boiling sensation and relieves discomfort better than placebo. The effects of using OB are longlasing, even after dosing is stopped. Studies have shown that treatment with OB bromide improves quality of life. This article describes the mechanism of action, synthesis, pharmacological effects of OB and aspects in which OB improves a person's quality of life.
“…As shown above, for random examples selected, the biggest error was 3.11%, which proves very good agreement between the value computed by trained ANN and the value computed due to homogenization algorithm [10]. Those magnitudes of values of error in homogenization computations are acceptable as shown in [12,18].…”
Section: Discussionsupporting
confidence: 68%
“…However, it should be properly conditioned to avoid overfitting. Other more advanced ANN architectures such as convolutional, recurrent networks or physics-based neural networks [18,32] were not explored in the study. The application of such architectures or the use of other machine learning regressors could improve accuracy and/or generalizability and could be included in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…Another example could be the paper of Staszak et al [13], in which it was shown that the precast concrete slabs reinforced with spatial linear trusses may be efficiently homogenized to one effective layer of a representative shell element. On the other hand, the computational time (ii) can be reduced by using soft computing methods such as the artificial neural network (ANN) algorithms [14][15][16][17][18] or metamodeling [19,20]. This usually requires a significant computational effort, which is incurred before the solution of the target computational problem is needed, but it allows one to obtain a solution with an acceptably small error in a fraction of a second when the actual problem occurs.…”
The main goal of this work is to combine the usage of the numerical homogenization technique for determining the effective properties of representative volume elements with artificial neural networks. The effective properties are defined according to the classical laminate theory. The purpose is to create and train a rapid surrogate model for the quick calculation of the mechanical properties of hollow concrete slabs. First, the homogenization algorithm was implemented, which determines membrane, bending and transverse shearing properties of a given parametrized hollow-core precast slab reinforced with steel bars. The algorithm uses the finite element mesh but does not require a formal solution of the finite element method problem. Second, the learning and training artificial intelligence framework was created and fed with a dataset obtained by optimal Latin hypercube sampling. In the study, a multilayer perceptron type of artificial neural network was used. This allows for obtaining rapid calculations of the effective properties of a particular hollow-core precast slab by using a surrogate model. In the paper, it has been proven that such a model, obtained via complex numerical calculations, gives a very accurate estimation of the properties and can be used in many practical tasks, such as optimization problems or computer-aided design decisions. Above all, the efficient setup of the artificial neural network has been sought and presented.
“…The best-known empirical formula for sizing for stack loading is the McKee equation, which attempts to determine the compressive strength of a corrugated box based on the Edge Crush Test (ECT) of the corrugated sheet [ 19 ]. The ECT of a corrugated board can be estimated by artificial intelligence [ 20 ]. Several authors have modified the original equation, and Kellicut and Landt attempted to use the ring crush test (RCT) value [ 21 ].…”
The finite element method is a widely used numerical method to analyze structures in virtual space. This method can be used in the packaging industry to determine the mechanical properties of corrugated boxes. This study aims to create and validate a numerical model to predict the compression force of corrugated cardboard boxes by considering the influence of different cutout configurations of sidewalls. The types of investigated boxes are the following: the width and height of the boxes are 300 mm in each case and the length dimension of the boxes varied from 200 mm to 600 mm with a 100 mm increment. The cutout rates were 0%, 4%, 16%, 36%, and 64% with respect to the total surface area of sidewalls of the boxes. For the finite element analysis, a homogenized linear elastic orthotropic material model with Hill plasticity was used. The results of linear regressions show very good estimations to the numerical and experimental box compression test (BCT) values in each tested box group. Therefore, the numerical model can give a good prediction for the BCT force values from 0% cutout to 64% cutout rates. The accuracy of the numerical model decreases a little when the cutout rates are high. Based on the results, this paper presents a numerical model that can be used in the packaging design to estimate the compression strength of corrugated cardboard boxes.
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