Estimation of the dietary requirement for vitamin D in healthy adults

Cashman, Kevin D.; Hill, Tom R.; Lucey, Alice; Taylor, Nicola; Seamans, Kelly M.; Muldowney, Siobhan; Fitzgerald, Anthony P.; Flynn, Albert; Barnes, Maria S.; Horigan, Geraldine; Bonham, Maxine P.; Duffy, Emeir M.; Strain, JJ; Wallace, Julie; Kiely, Máiréad

doi:10.3945/ajcn.2008.26594

Cited by 222 publications

(235 citation statements)

References 30 publications

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“…[20,21] One study suggested daily requirements of at least 1,600 IU D3 for optimal serum levels. [21] This dose was further analyzed in a randomized placebo control trial, where the mean serum 25(OH)D increased from 20.6 ng/ml to 33.7 ng/ml in the treatment group, but declined to 18.5 ng/ ml in the control group. [20] However, while encouraging, these findings suggest that even 1,600 IU D3 daily may fail to achieve the optimal serum threshold.…”

Section: Discussionmentioning

confidence: 99%

“…[7,8,18,19] Numerous advantages of maintaining appropriate serum 25(OH)D continue to emerge, however, appropriate management remains controversial. [7,18,20,21] Multiple dosing protocols have been evaluated. [20,21] One study suggested daily requirements of at least 1,600 IU D3 for optimal serum levels.…”

Section: Discussionmentioning

confidence: 99%

“…[7,18,20,21] Multiple dosing protocols have been evaluated. [20,21] One study suggested daily requirements of at least 1,600 IU D3 for optimal serum levels. [21] This dose was further analyzed in a randomized placebo control trial, where the mean serum 25(OH)D increased from 20.6 ng/ml to 33.7 ng/ml in the treatment group, but declined to 18.5 ng/ ml in the control group.…”

Section: Discussionmentioning

confidence: 99%

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Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Naylor

King²,

Voges³

et al. 2017

ReconRev

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Background: The importance of appropriate serum 25-hydroxy vitamin D [25(OH)D] for multiple health measures is widely described, however, the prevalence of vitamin D deficiency remains remarkably high. The goal of our study is to explore the distribution of vitamin D deficiency among an elective total joint arthroplasty (TJA) population within a lower latitude climate with relatively abundant sunshine. We hypothesize this group will demonstrate a high prevalence of vitamin D deficiency, thus exposing a potential opportunity to improve outcomes with proper identification and management.Methods: From January to December, 2014, serum 25(OH)D levels were collected during a standard preoperative workup prior to primary or revision joint arthroplasty in South Carolina. Mean serum 25(OH)D, seasonal variation, and patient demographics were recorded. We defined Vitamin D deficiency consistent with the current Endocrine Society classification: serum 25(OH)D < 20 ng/ml, 21-29 ng/ml, and 30-100 ng/ml representing deficiency, insufficiency, and normal, respectively.Results: A total of 308 patients underwent evaluation. 46.8% (144) of the participants were female, and 89.6% (276) identified as Caucasian. The mean patient age was 68.3 years ±13.8 (32-88

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Naylor

King²,

Voges³

et al. 2017

ReconRev

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“…Both dietary supplementation and sunshine exposure are effective in preventing vitamin D deficiency (2,10). There is clear evidence that UV light exposure, consuming vitamin D-fortified food, and/or vitamin D supplementation has a positive impact on serum 25-hydroxyvitamin D (25OHD) concentrations, and adults can tolerate vitamin D at doses above the current dietary reference intake levels (11)(12)(13). Though both D2 and D3 have been used as supplements, D2 is less efficient compared with D3 for increasing serum 25OHD (10,14,15).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology

Bunch

Miller

Wang

2009

Clinical Chemistry and Laboratory Medicine

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Background: Vitamin D is important to health and disease. Liquid chromatography-tandem mass spectrometry (LC-MSMS) is considered the most accurate technology for quantification of serum 25-hydroxyvitamin D (25OHD) which is the best biomarker for estimating vitamin D nutritional status. Methods: Serum was mixed with acetonitrile containing hexadeuterated 25-hydroxyvitamin D 3 (d 6 -25OHD3) and centrifuged 10 min at 15,634=g. The supernatant was injected onto a turbulent flow preparatory column then transferred to a polar endcapped C18 analytical column. The mass spectrometer was set for positive atmospheric pressure chemical ionization. Results:The analytical cycle time was 5.5 min. Interand intra-assay CV for both analytes across three concentrations ranged from 3.8% to 14.2%. The method was linear from 3.0 to 283.6 nmol/L for 25-hydroxyvitamin D 3 (25OHD3) and 4.6 to 277.9 nmol/L for 25-hydroxyvitamin D 2 (25OHD2), with an accuracy of 88.7%-118.7% and 90.7%-100.3%, respectively. No carryover or ion suppression was observed. Comparison with a radioimmunoassay using patient specimens (ns527) showed a mean difference of 5.

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Estimation of the dietary requirement for vitamin D: impact of season

et al. 2012

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We have estimated the dietary requirement for vitamin D for a number of population sub-groups in winter (1)(2)(3) on the basis that the relative contribution of exposure of skin to UVB radiation from sunshine and diet to vitamin D status and vitamin D requirements are not fully understood. The North American Institute of Medicine took the same approach in establishing their recent Dietary Reference Intakes for vitamin D (4) . It has been suggested that these estimates of requirement would be much lower in the presence of UVB sunshine.The objective of this study was to establish the distribution of dietary requirements for the maintenance of nutritional adequacy of vitamin D in adolescent girls during the darker part of the year (February to May) and the sunnier part of the year (August to November), as indicated by serum 25-hydroxyvitamin D (25(OH)D) concentrations ranging from ‡ 25 to ‡ 50 nmol/l. This was possible by using data available from 2 randomised, double-blind, placebo-controlled, 12-month vitamin D 3 intervention studies in adolescent Danish (55 N) and Finnish (60 N) girls (aged 11.3 y) (5,6) . Serum 25(OH)D was measured with a HPLC assay in a centralised laboratory. Girls were not sampled in June and July due to school holidays.The mean serum 25(OH)D of the group of girls at baseline was 33.2 and 55.0 nmol/l, in February to May (n 157) and August to November (n 238), respectively. Regression analysis and mathematical modelling of the relationship between total vitamin D intake and status 3 at endpoint (month 12) showed that the vitamin D intake requirement at the 50 th percentile (%ile) ranged from 0 to 13.9 mg/d depending on serum 25(OH)D threshold and season (see Table). The vitamin D intake requirement at the 97.5 th percentile (i.e., the Recommended Daily Allowance [RDA]) showed greatest variability across the two seasonal sub-groups at low serum 25(OH)D thresholds ( ‡ 25 and ‡ 30 nmol/l) but converged at higher thresholds ( ‡ 40 and ‡ 50 nmol/l) (see Table). Even in the presence of late-summer UVB sunshine, vitamin D intakes of 3.9 and 8.8 mg/d were needed to maintain 97.5% of the 11-y old girls with serum 25(OH)D ‡ 25 and ‡ 30 nmol/l, respectively, compared to 11.6 and 14.3 mg/d, respectively, during late-winter. Despite the presence of late-summer UVB sunshine, 18.9 and 29.6 mg/d were needed to maintain serum 25(OH)D > 40 and 50 nmol/l, respectively. In conclusion, there is a dietary requirement for vitamin D for adolescent girls living at northern latitudes even in late-summer, and the RDA depends on the serum 25(OH)D threshold.

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Estimation of the dietary requirement for vitamin D in healthy adults

Abstract: The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH)D] in the vast majority (>97.5%) of 20-40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 microg/d.

Cited by 222 publications

References 30 publications

Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology

Estimation of the dietary requirement for vitamin D: impact of season

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