Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of canine skin infections

Vlaenderen, I Van; Nautrup, B Poulsen; Gasper, S.

doi:10.1016/j.prevetmed.2011.01.006

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…In some countries (where there are distinct seasons) disease transmission is seasonal but in the areas of the world with more temperate climates or in the subtropical or tropical regions, disease transmission is a year round problem. It has been shown that the simpler a treatment protocol is, the more likely an owner is to comply [11]. Poor owner compliance has also been seen as possibly due to veterinarians relying increasingly on broad spectrum anti-parasitic drugs and very short consultations.…”

Section: Introductionmentioning

confidence: 99%

The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

et al. 2012

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BackgroundThe control of tick and flea burdens in dogs and cats has become essential to the control of important and emerging vector borne diseases, some of which are zoonoses. Flea worry and flea bite hypersensitivity are additionally a significant disease entity in dogs and cats. Owner compliance in maintaining the pressure of control measures has been shown to be poor. For these reasons efforts are continuously being made to develop ectoparasiticides and application methods that are safe, effective and easy to apply for pet owners. A new polymer matrix collar has recently been developed which is registered for 8 months use in cats and dogs. The basic properties of this collar have been investigated in several in vitro and in vivo studies.MethodsThe effects of imidacloprid, flumethrin and the combination were evaluated in vitro by means of whole cell voltage clamp measurement experiments conducted on isolated neuron cells from Spodoptera frugiperda. The in vitro efficacy of the two compounds and the combination against three species of ticks and their life stages and fleas were evaluated in a dry surface glass vial assay. The kinetics of the compounds over time in the collar were evaluated by the change in mass of the collar and measurement of the surface concentrations and concentrations of the actives in the collar matrix by HPLC. Hair clipped from collar treated dogs and cats, collected at various time points, was used to assess the acaricidal efficacy of the actives ex vivo.ResultsAn in vitro isolated insect nerve model demonstrated the synergistic neurotoxic effects of the pyrethroid flumethrin and the neonicotinoid imidacloprid. An in vitro glass vial efficacy and mortality study against various life stages of the ticks Ixodes ricinus, Rhipicephalus sanguineus and Dermacentor reticulatus and against the flea (Ctenocephalides felis) demonstrated that the combination of these products was highly effective against these parasites. The release kinetics of these actives from a neck collar (compounded with 10% imidacloprid and 4.5% flumethrin) was extensively studied in dogs and cats under laboratory and field conditions. Acaricidal concentrations of the actives were found to be consistently released from the collar matrix for 8 months. None of the collar studies in dogs or cats were associated with any significant collar related adverse event.ConclusionHere we demonstrated the synergism between the pyrethroid flumethrin and the neonicotinoid imidacloprid, both provided in therapeutically relevant doses by a slow release collar matrix system over 8 months. This collar is therefore a convenient and safe tool for a long-term protection against ectoparasites.

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Section: Introductionmentioning

confidence: 99%

The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

et al. 2012

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“…First-line antibiotics include established and well-tolerated narrow and broad-spectrum drugs with antistaphylococcal activity: cefadroxil, cefalexin, clavulanate amoxicillin, clindamycin and lincomycin. Cefovecine can be used as first-line antibiotics as long as medication may be difficult to administer, and/or compliance is likely to be poor [15]. In this case Huma had previous episodes of gastroenteritis during antibiotherapy, SQ Cefovecine 8mg/kg every 14 days was choosed as treatment for her skin infection.…”

Section: Discussionmentioning

confidence: 99%

Control of Recurrent Pyoderma with PYOspot® in an Atopic Dog

Lorente-Méndez¹,

Ruiz-Tapia²

2016

IJVHSR

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“…Other controversial aspects of the analysis relate to ethical concerns arising from the valuation of natural effects, including health. Discounting benefits, for example, implies that an effect observed in the present is more valuable than if observed in the future (27).…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis: adding value to assessment of animal health, welfare and production

Martins¹,

Rushton²

2014

Rev. Sci. Tech. OIE

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Cost-effectiveness analysis (CEA) has been extensively used in economic assessments in fields related to animal health, namely in human health where it provides a decision-making framework for choices about the allocation of healthcare resources. Conversely, in animal health, cost-benefit analysis has been the preferred tool for economic analysis. In this paper, the use of CEA in related areas and the role of this technique in assessments of animal health, welfare and production are reviewed. Cost-effectiveness analysis can add further value to these assessments, particularly in programmes targeting animal welfare or animal diseases with an impact on human health, where outcomes are best valued in natural effects rather than in monetary units. Importantly, CEA can be performed during programme implementation stages to assess alternative courses of action in real time.

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Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of canine skin infections

Cited by 12 publications

References 25 publications

The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

Control of Recurrent Pyoderma with PYOspot® in an Atopic Dog

Cost-effectiveness analysis: adding value to assessment of animal health, welfare and production

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