Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves

Varon, Leonardo A. Bermeo; Orlande, Helcio R. B.; Eliçabe, Guillermo E.

doi:10.1016/j.ijthermalsci.2015.06.022

Cited by 40 publications

(18 citation statements)

References 34 publications

(51 reference statements)

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“…Temperature increase due to SAR from RF fields has been numerically and experimentally validated with phantom models that provide good agreement and demonstrate the possibility of using simulations to ensure safety during MRI [52]. The feasibility of using nanoparticles with RF systems has been reported with phantom models to increase tissue temperature in localized and deep-seated tumor regions [49, 50, 77]. The addition of magnetic nanoparticles to regions drew more heat than that by surrounding regions in both simulations and MR thermometry [50], and a two-channel RF system exhibited superior capability in localizing heat to the nanoparticle-mediated tumor region compared with that in the normal region [77].…”

Section: Locoregional Hyperthermia Therapymentioning

confidence: 99%

Role of Simulations in the Treatment Planning of Radiofrequency Hyperthermia Therapy in Clinics

Prasad

Kim

2019

Journal of Oncology

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Hyperthermia therapy is a treatment modality in which tumor temperatures are elevated to higher temperatures to cause damage to cancerous tissues. Numerical simulations are integral in the development of hyperthermia treatment systems and in clinical treatment planning. In this study, simulations in radiofrequency hyperthermia therapy are reviewed in terms of their technical development and clinical aspects for effective clinical use. This review offers an overview of mathematical models and the importance of tissue properties; locoregional mild hyperthermia therapy, including phantom and realistic human anatomy models; phase array systems; tissue damage; thermal dose analysis; and thermoradiotherapy planning. This review details the improvements in numerical approaches in treatment planning and their application for effective clinical use. Furthermore, the modeling of thermoradiotherapy planning, which can be integrated with radiotherapy to provide combined hyperthermia and radiotherapy treatment planning strategies, are also discussed. This review may contribute to the effective development of thermoradiotherapy planning in clinics.

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Section: Locoregional Hyperthermia Therapymentioning

confidence: 99%

Role of Simulations in the Treatment Planning of Radiofrequency Hyperthermia Therapy in Clinics

Prasad

Kim

2019

Journal of Oncology

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“…During medical procedures based on radiofrequency ablation caused by the electric field, a current with frequencies in the range of tens to several hundred kHz is induced. In such a frequency range, the electromagnetic wave length is much larger than the depth of the human body; therefore, the current flow is via electrical conductivity and can be analyzed as a so-called quasi-static formulation, which allows coupling the electrical and thermal conductivity problem [8,[17][18][19][20][21][22]. To determine the internal heat source resulting from the influence of the electric field, it is necessary to know the intensity of the electric field, which is dependent on the electric conductivity coefficient.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Breast Tumor Destruction Using Fast Heating during Radiofrequency Ablation

Paruch

2019

Materials

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In oncology, hyperthermia is understood as a planned, controlled technique of heating cancerous changes in order to destroy their cells or stop their growth. In clinical practice, hyperthermia is used in combination with radiotherapy, chemotherapy, or immunological therapy. During the hyperthermia, the tissue is typically exposed to a temperature in the range of 40-45 • C, the exception is thermoablation, during which the temperatures reach much higher values. Thermoablation is characterized by the use of high temperatures up to 90 • C. The electrode using the radiofrequency is inserted into the central area of the tumor. Interstitial thermoablation is used to treat, among others, breast and brain cancer. The therapy consists of inducing coagulation necrosis in an area that is heated to very high temperatures. Mathematical modeling is based on the use of a coupled thermo-electric model, in which the electric field is described by means of the Laplace equation, while the temperature field is based on the Pennes equation. Coupling occurs at the level of the additional source function in the Pennes equation. The temperature field obtained in this way makes it possible to calculate the Arrhenius integral as a determinant of the destruction of biological tissue. As a result of numerical calculations regarding the temperature field and the Arrhenius integral, it can be concluded that, with the help of numerical tools and mathematical modeling, one can simulate the process of destroying cancerous tissue.

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“…The derived solution is applied to study two distinct spatially dependent heat sources that characterize the heating induced by magnetic nanoparticles subjected to an electromagnetic field. Varon et al dealt with numerical simulations under uncertainties of the treatment of cancer based on hyperthermia, induced by radiofrequency electromagnetic waves in a 2‐D region, where the tumor is supposed to be loaded with nanoparticles. The focus of the study was to find a solution to the inverse problem of dealing with the estimation of state variables, like the temperature distribution in the tissues.…”

Section: Introductionmentioning

confidence: 99%

Fundamental solution of steady and transient bio heat transfer equations especially for skin burn and hyperthermia treatments

Deka

Bhanja

Nath

2018

Heat Trans. Asian Res.

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In the field of bio heat transfer, as of now, the main concern of researchers lies in the proper and accurate thermal damage of the diseased tissues without destroying or damaging the neighboring healthy tissues during the tumor treatment. The present work aims to develop a new approach toward solving the bio heat transfer equations for the skin burn and hyperthermia treatments. Both analytical and numerical solutions are proposed. For the analytical study, a differential transform method is used to solve steady and unsteady state heat equations. The finite volume method is adopted to solve these equations numerically, which provides a better scope to solve the highly nonlinear complex equations. To obtain a complete solution, a code is developed in MATLAB and MATHEMATICA. The variation of different parameters, such as perfusion constant, space heating, surface step heating, and thermal conductivity, with time were observed. Apart from the above analysis of temperature distribution during skin burn through the spilling of hot beverage, its numerical solution was also performed for this problem at different boundary conditions. It was observed that with the help of the temperature distribution, depending on the time and the severity of the burn, different ranges of depths of the burn can be determined.

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Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves

Cited by 40 publications

References 34 publications

Role of Simulations in the Treatment Planning of Radiofrequency Hyperthermia Therapy in Clinics

Role of Simulations in the Treatment Planning of Radiofrequency Hyperthermia Therapy in Clinics

Mathematical Modeling of Breast Tumor Destruction Using Fast Heating during Radiofrequency Ablation

Fundamental solution of steady and transient bio heat transfer equations especially for skin burn and hyperthermia treatments

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