Abstract:The presence of free silanols on alkyl-bonded reversed-phase stationary phases is responsible for broad and asymmetrical peaks when basic drugs are chromatographed with conventional octadecylsilane (C18) columns due to ionic interactions. In the last few years, ionic liquids (ILs) have attracted attention to reduce this undesirable silanol activity. ILs should be considered as dual modifiers (with a cationic and anionic character), which means that both cations and anions are able to adsorb on the stationary p… Show more
“…Ruiz-Angel [22] applied a mathematical model based on two chemical equilibria to estimate the association constants between the solutes and alkyl-bonded stationary phase, as well as those between solutes and the additive in the mobile phase. The constant values, together with the changes in retention and peak shape, revealed information about the retention mechanism and reducing the "silanol effect".…”
Ionic liquids (ILs) are non-molecular solvents; specifically, molten salts with low melting points, often below 100 °C and even below room temperature, thus allowing these solvents to remain liquid [...]
“…Ruiz-Angel [22] applied a mathematical model based on two chemical equilibria to estimate the association constants between the solutes and alkyl-bonded stationary phase, as well as those between solutes and the additive in the mobile phase. The constant values, together with the changes in retention and peak shape, revealed information about the retention mechanism and reducing the "silanol effect".…”
Ionic liquids (ILs) are non-molecular solvents; specifically, molten salts with low melting points, often below 100 °C and even below room temperature, thus allowing these solvents to remain liquid [...]
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