Estimation of serum malondialdehyde in oral cancer and precancer and its association with healthy individuals, gender, alcohol, and tobacco abuse

Chole, Revant; Patil, Ranjitkumar; Basak, Anjan; Palandurkar, Kamlesh; Bhowate, Rahul

doi:10.4103/0973-1482.77106

Cited by 94 publications

(93 citation statements)

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“…Genetic aberrations caused by ST include activation of ras, uncommon in smokers but mutational hot spots in p53 encountered are similar to those in smokers (Warnakulasuriya and Ralhan, 2007). Previous studies have demonstrated that an aqueous ST extract when given in a single oral dose to experimental rats results in an superior induction of liver lipid peroxidation, hepatic DNA single strand breaks (apoptosis marker), and a marked augmentation in the urinary excretion of the lipid metabolites malondialdehyde, formaldehyde, acetaldehyde, and acetone (Bagchi et al, 1994;Bagchi, 1997;Chole et al, 2010;Ramya et al, 2011;Kurtul and Gökpınar, 2012). A previous study indicated that the acute exposure of HOK-16B cells to ST leads to cell death, at least in part, through oxidative stress via up-regulation of ASK1 and the JNK 1/2 and p38 signaling pathways.…”

Section: Oral Cancer and Shammah In Saudi Arabiamentioning

confidence: 99%

Smokeless Tobacco (Shammah) in Saudi Arabia: A Review of its Pattern of Use, Prevalence, and Potential Role in Oral Cancer

Alsanosy¹

2014

Asian Pacific Journal of Cancer Prevention

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Section: Oral Cancer and Shammah In Saudi Arabiamentioning

confidence: 99%

Smokeless Tobacco (Shammah) in Saudi Arabia: A Review of its Pattern of Use, Prevalence, and Potential Role in Oral Cancer

Alsanosy¹

2014

Asian Pacific Journal of Cancer Prevention

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“…There are different forms of clinical appearances of OLP including linear, annular, popular, reticular and plaque shape, also atrophic, erosive (ulcerative) and bullous lesions in oral spaces at different periods or similar (Scully, Carrozzo, & Cartan, 2008). There are many studies in oxidative state of biological systems including production of ROS, oxidative stress and antioxidant defense, inflammation and chronic diseases that have been studied in degenerative and carcinogenesis disease (Ergun et al, 2011;Chole et al, 2010;Agha-Hosseini et al, 2009). The first step of production of oxidative stress is the metabolic reactions that use oxygen and represent disturbance balance in pro-oxidant/antioxidant reactions in living organisms (Valko et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

Shiva¹,

Arab²

2016

GJHS

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Background: Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.Objective: To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples. Material & Methods:The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman's rho correlation coefficient for assessing association between serum and salivary fluids.Results: TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values. Conclusion:This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance.

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“…MDA is a major genotoxic carbonyl compound generated by lipid peroxidation and during arachidonic acid metabolism for the synthesis of prostaglandins. Hence, MDA levels are used to indicate oxidative and cellular damage to tissues due to ROS and free radicals (9,11).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary and serum lipid peroxidation, and glutathione in oral leukoplakia and oral squamous cell carcinoma

Metgud

Bajaj

2014

J Oral Sci

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Lipid peroxidation induced by reactiveoxygen species (ROS) is involved in the pathogenesis of malignancy. Overall, lipid peroxidation levels are indicated by malondialdehyde (MDA), which is the most frequently used biomarker to detect oxidative changes. Antioxidant defense systems such as glutathione (GSH) limit cell injury induced by ROS. Therefore, MDA and GSH can be used to monitor oxidative stress (OS). Hence, this study aimed to evaluate and compare both salivary and serum levels of MDA and GSH in oral leukoplakia and oral squamous cell carcinoma (OSCC) patients, and healthy controls. The study included 100 subjects comprising 30 apparently healthy controls, 30 patients with oral leukoplakia and 40 clinically and histologically diagnosed patients with OSCC. Saliva and blood samples were obtained and evaluated for MDA and GSH. The study revealed enhanced MDA levels in saliva and serum in oral leukoplakia and OSCC patients as compared to controls. On the other hand, significant decreases were seen in serum and salivary GSH levels in oral leukoplakia and OSCC patients as compared to controls. Augmentation of OS in blood and saliva is reflected by increase in MDA and decrease in GSH levels, indicating that tumor processes cause an imbalance of oxidant-antioxidant status in cell structures.(J Oral Sci 56, 135-142, 2014)

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Estimation of serum malondialdehyde in oral cancer and precancer and its association with healthy individuals, gender, alcohol, and tobacco abuse

Abstract: Increased serum malondialdehyde in oral cancer and oral precancer would serve as a valuable marker for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis.

Cited by 94 publications

References 0 publications

Smokeless Tobacco (Shammah) in Saudi Arabia: A Review of its Pattern of Use, Prevalence, and Potential Role in Oral Cancer

Smokeless Tobacco (Shammah) in Saudi Arabia: A Review of its Pattern of Use, Prevalence, and Potential Role in Oral Cancer

Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

Evaluation of salivary and serum lipid peroxidation, and glutathione in oral leukoplakia and oral squamous cell carcinoma

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