Estimation of serum iron and protein levels in oral submucous fibrosis: A clinical research

Abstract

Background: Oral submucous fibrosis (OSMF) is a potentially malignant oral condition which shares a unique predisposition of occurrence in the Indian subcontinent, parts of Asia and among individuals of the Indian origin abroad and continues to rise in incidence between younger and older people. Therefore, early detection of the disease can serve as the best available tool and can play a significant role in providing effective treatment at the appropriate time and thus preventing it from malignant transformation. Aim: To estimate and compare the serum iron and protein levels between OSMF and normal subjects. Materials and Methods: A study was conducted in which 60 patients of age group 18-45 year were taken, out of which 30 were clinically and histopathologically diagnosed as OSMF and 30 were normal. All 60 subjects were evaluated for serum iron and protein levels. Statistical analysis was done by unpaired t-test followed by one-way ANOVA test. Results: Statistical analysis of the data obtained a significant variation in serum iron and protein levels in OSMF and normal subjects. Serum level of iron showed significant reduction when compared to normal subjects while mean serum level of protein showed a gradual increase compared to normal subjects. Conclusion: It can be suggested that biochemical assessment of patients with areca nut chewing habit may help in the earlier diagnosis of OSMF and thus may lead to a better prognosis of these lesions.

Evaluation of Serum Copper (Cu), Serum Iron (Fe) and Serum Copper (Cu) / Iron (Fe) Ratio in Oral Submucous Fibrosis in Karachi

“…[33]. Other studies conducted by Saurabh et al [34], Kode et al [17] and Tadakamadla et al [30] were also found consistent. The difference in serum iron levels in the present study and Indian studies is due to the difference in the type of diet intake as Indians preferred vegetarian diet as compared to the non vegetarian diet which is common in the society.…”

Total serum protein estimation and its correlation with clinical and histopathological grading using Masson's Trichrome stain in patients of oral submucous fibrosis

“…[ 8 9 10 11 ] There are also studies only on protein estimation. [ 12 13 14 15 16 17 ] However, there are not any studies which correlate functional, clinical, and histopathological grading with total protein estimation.…”

“…Studies have shown that the TSP level in the serum of OSMF patients was found to be significantly higher than that of normal individuals. [ 14 15 16 17 18 20 ]…”