Estimation of Serum Granulysin in Vitiligo patients

Abstract

Background: Vitiligo is a chronic immune-mediated inflammatory skin disease, it is a disorder of both the innate and adaptive immune system. Objectives: The aim of this work was to evaluate serum level of granulysin in vitiligo patients. Methods: This case control study included 30 patients suffering from vitiligo. In addition, 20 apparently healthy individuals. Measurement of serum granulysin using enzyme-linked immunosorbent assay was performed in all subjects. Results: When compared to the control group, the vitiligo group had significantly higher serum granulysin levels (P< 0.02). Conclusions: Granulysin levels in the blood may contribute to the pathogenesis of vitiligo.

Assessment of serum granulysin and cathepsin-L levels in vitiligo patients

“…In a recent study, Mohammed et al 15 investigated granulysin levels in vitiligo and found that serum granulysin levels are higher in vitiligo patients than in healthy volunteers, similar to this study, and that the molecular level is not associated with disease severity and activity. In another recent study, granulysin levels were found to be higher in the patient group than in healthy volunteers, and unlike this study, a positive correlation was found between the molecule and disease severity and activity 16 .…”

“…In a recent study, Mohammed et al 15 investigated granulysin levels in vitiligo and found that serum granulysin levels are higher in vitiligo patients than in healthy volunteers, similar to this study, and that the molecular level is not associated with disease severity and activity. In another recent study, granulysin levels were found to be higher in the patient group than in healthy volunteers, and unlike this study, a positive correlation was found between the molecule and disease severity and activity 16 . Granulysin and cathepsin-L levels in vitiligo Oba et al 27 from our country, who examined serum granulysin levels before and after treatment with tofacitinib in patients with alopecia areata, found that the serum granulysin levels decreased significantly after treatment compared with baseline and that this molecule level was correlated with the immunological activity of alopecia areata.…”

“…There is a need for molecules and parameters that will help clinicians overcome these difficulties and provide clues to disease severity, activity status, and clinical course. There are a very limited number of recent studies on the possible role of granulysin and cathepsin-L in the etiopathogenesis of vitiligo and as indicators of disease severity and activity 15 , 16 . To the best of our knowledge, this study is the first to simultaneously investigate the possible role of these two molecules in the pathogenesis of vitiligo as indicators of cellular immunity and cytotoxicity.…”