Estimation of salivary lactate dehydrogenase in oral leukoplakia and oral squamous cell carcinoma: A biochemical study

Abstract

The present salivary analysis for LDH enzyme reveals an overall altered salivary LDH enzyme level in OL and OSCC cases.

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

“…The comparison of salivary LDH levels between oral cancer and healthy subjects was statistically significant (p < 0.001). Our study finding was in agreement with the study done by Kallalli et al, 1 Lokesh et al, 8 Shetty et al, 16 Patel and Metgud, 4 and Joshi et al…”

“…18 In our study, there was a significant difference in the salivary and serum LDH levels between oral leukoplakia and healthy controls (p = 0.001). Our results were in accordance with the study conducted by Patel and Metgud, 4 Pereira et al, 6 Rathore et al, 9 Joshi et al, 11 Shetty et al, 16 and Achalli et al 19 In our present study, while comparing among all the study groups, we found that serum and salivary LDH levels were significantly higher in oral cancer followed by OSMF and oral leukoplakia. Intergroup comparison for mean value of salivary LDH levels was significantly higher in oral cancer group than control, oral leukoplakia, and OSMF groups (p < 0.0001).…”

“…4 In India, oral cancer is highly prevalent due to habit of tobacco chewing. 6 Classic features may include a white lesion, red lesion, mixed red and white lesion, lump, and ulcer with exophytic raised margin.…”

“…2,3 Recently, the role of tumor markers in the management of head and neck cancer has increased for attention. 4 Tumor markers are biologically elaborated by tumor cells due to either the cause or effect of malignant process substances. 5 Several tumor markers in both serum and saliva have been identified.…”

“…Serum LDHs have been studied extensively in various cancer and increased levels have been observed. 4 The LDH in the whole saliva within the oral cavity may originate from various sources, since whole saliva is a combination of secretions from both major and minor salivary glands, fluids diffused through the oral epithelium and gingiva, material originating from gastrointestinal reflux, cellular and other debris. 12 Therefore, salivary LDH may be evaluated for possible oral mucosal pathologies.…”