Estimation of renal function in lung cancer patients

Trobec, Katja; Knez, Lea; Brguljan, Pika Meško; Čufer, Tanja; Lainščak, Mitja

doi:10.1016/j.lungcan.2011.11.016

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…Another support using CKD-EPI for carboplatin dosing in lung cancer patients came from a recent study. Unfortunately the authors did neither correct for actual BSA which could have improved CKD-EPI-based dosing further nor did they report subgroup results despite an impressive sample size of 218 patients [25]. In the present study dose calculation using CKD-EPI-BSA performed better than CG-TBW but was inferior to CG-ABW especially in overweight patients.…”

Section: Discussioncontrasting

confidence: 55%

“…Both weight descriptors were studied in cancer patients receiving carboplatin, resulting in more accurate dosing than using TBW [18][19][20][21][22]. The 2009 introduced Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation [23] has not yet been widely tested for carboplatin dosing but nevertheless gave encouraging results compared to dose calculation according to CG with TBW (CG-TBW) and deserves further examination [21,24,25].…”

Section: Introductionmentioning

confidence: 99%

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Carboplatin dose calculation in lung cancer patients with low serum creatinine concentrations using CKD-EPI and Cockcroft–Gault with different weight descriptors

Kaag

2013

Lung Cancer

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Carboplatin dose calculation in lung cancer patients with low serum creatinine concentrations using CKD-EPI and Cockcroft–Gault with different weight descriptors

Kaag

2013

Lung Cancer

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“…12,13 The Wright equation was developed in a cohort of oncology patients and has been shown to be useful for dosing chemotherapeutic agents. 14,15 Similar to the MDRD, the Cockroft-Gault (CG) equation was developed in patients with kidney disease. 14 The CG is consistently featured in the literature, amidst inconsistent conclusions about superiority compared with the MDRD.…”

mentioning

confidence: 99%

“…14,15 Similar to the MDRD, the Cockroft-Gault (CG) equation was developed in patients with kidney disease. 14 The CG is consistently featured in the literature, amidst inconsistent conclusions about superiority compared with the MDRD. 9,14,16,17 …”

mentioning

confidence: 99%

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The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation

Osho

Castleberry

Snyder

et al. 2014

The Journal of Heart and Lung Transplantation

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BACKGROUND Methods for direct measurement of glomerular filtration rate (GFR) are expensive and inconsistently applied across transplant centers. The Modified Diet in Renal Disease (MDRD) equation is commonly used for GFR estimation, but is inaccurate for GFRs > 60 ml/min per 1.73 m2. The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) and Wright equations have shown improved predictive capabilities in some patient populations. We compared these equations to determine which one correlates best with direct GFR measurement in lung transplant candidates. METHODS We conducted a retrospective cohort analysis of 274 lung transplant recipients. Pre-operative GFR was measured directly using a radionuclide GFR assay. Results from the MDRD, CKDEPI, Wright, and Cockroft–Gault equations were compared with direct measurement. Findings were validated using logistic regression models and receiver operating characteristic (ROC) analyses in looking at GFR as a predictor of mortality and renal function outcomes post-transplant. RESULTS Assessed against the radionuclide GFR measurement, CKDEPI provided the most consistent results, with low values for bias (0.78), relative standard error (0.03) and mean absolute percentage error (15.02). Greater deviation from radionuclide GFR was observed for all other equations. Pearson’s correlation between radionuclide and calculated GFR was significant for all equations. Regression and ROC analyses revealed equivalent utility of the radionuclide assay and GFR equations for predicting post-transplant acute kidney injury and chronic kidney disease (p < 0.05). CONCLUSIONS In patients being evaluated for lung transplantation, CKDEPI correlates closely with direct radionuclide GFR measurement and equivalently predicts post-operative renal outcomes. Transplant centers could consider replacing or supplementing direct GFR measurement with less expensive, more convenient estimation by using the CKDEPI equation.

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Effects of unidentified renal insufficiency on the safety and efficacy of chemotherapy for metastatic colorectal cancer patients: a prospective, observational study

Chen

Wang

Luo

et al. 2014

Support Care Cancer

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Estimation of renal function in lung cancer patients

Cited by 11 publications

References 22 publications

Carboplatin dose calculation in lung cancer patients with low serum creatinine concentrations using CKD-EPI and Cockcroft–Gault with different weight descriptors

Carboplatin dose calculation in lung cancer patients with low serum creatinine concentrations using CKD-EPI and Cockcroft–Gault with different weight descriptors

The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation

Effects of unidentified renal insufficiency on the safety and efficacy of chemotherapy for metastatic colorectal cancer patients: a prospective, observational study

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