Estimation of regional bone metabolism from whole-body 18F-fluoride PET static images

Siddique, Musib; Blake, Glen M.; Frost, Michelle L.; Moore, Amelia; Puri, Tanuj; Marsden, Paul; Fogelman, Ignac

doi:10.1007/s00259-011-1966-y

Cited by 44 publications

(76 citation statements)

References 15 publications

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“…Alternative methods to the Hawkins model for analysing the bone TAC and IF curves to evaluate K 1 and K i include deconvolution and spectral analysis [79]. A fourth method, the Patlak plot, provides a simple graphical method of evaluating K i , but cannot be used to find K 1 [79].…”

Section: Quantitative 18 F-naf Pet Imaging the Hawkins Methodsmentioning

confidence: 99%

18F-NaF PET/CT: EANM procedure guidelines for bone imaging

Beheshti

Mottaghy

Payche

et al. 2015

Eur J Nucl Med Mol Imaging

122

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The aim of this guideline is to provide minimum standards for the performance and interpretation of (18)F-NaF PET/CT scans. Standard acquisition and interpretation of nuclear imaging modalities will help to provide consistent data acquisition and numeric values between different platforms and institutes and to promote the use of PET/CT modality as an established diagnostic modality in routine clinical practice. This will also improve the value of scientific work and its contribution to evidence-based medicine.

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Section: Quantitative 18 F-naf Pet Imaging the Hawkins Methodsmentioning

confidence: 99%

18F-NaF PET/CT: EANM procedure guidelines for bone imaging

Beheshti

Mottaghy

Payche

et al. 2015

Eur J Nucl Med Mol Imaging

122

View full text Add to dashboard Cite

show abstract

“…While there does not yet seem to be a consensus on whether to use static or dynamic PET, studies suggest that static PET may be able to closely approximate 1-h dynamic PET values of regional blood clearance while completing a scan in only 5 min [26][27][28]. To compare the measurements obtained by static PET to those of dynamic PET, one study retrospectively collected dynamic NaF-PET data of 38 postmenopausal women with osteoporosis [27].…”

Section: Osteoporosismentioning

confidence: 98%

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Raynor

Houshmand

Gholami

et al. 2016

Curr Osteoporos Rep

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(18)F-sodium fluoride (NaF) as an imaging tracer portrays calcium metabolic activity either in the osseous structures or in soft tissue. Currently, clinical use of NaF-PET is confined to detecting metastasis to the bone, but this approach reveals indirect evidence for disease activity and will have limited use in the future in favor of more direct approaches that visualize cancer cells in the read marrow where they reside. This has proven to be the case with FDG-PET imaging in most cancers. However, a variety of studies support the application of NaF-PET to assess benign osseous diseases. In particular, bone turnover can be measured from NaF uptake to diagnose osteoporosis. Several studies have evaluated the efficacy of bisphosphonates and their lasting effects as treatment for osteoporosis using bone turnover measured by NaF-PET. Additionally, NaF uptake in vessels tracks calcification in the plaques at the molecular level, which is relevant to coronary artery disease. Also, NaF-PET imaging of diseased joints is able to project disease progression in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Further studies suggest potential use of NaF-PET in domains such as back pain, osteosarcoma, stress-related fracture, and bisphosphonate-induced osteonecrosis of the jaw. The critical role of NaF-PET in disease detection and characterization of many musculoskeletal disorders has been clearly demonstrated in the literature, and these methods will become more widespread in the future. The data from PET imaging are quantitative in nature, and as such, it adds a major dimension to assessing disease activity.

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“…Provided that the Hawkins model rate constant k 4 is negligibly small, Patlak analysis provides a simple alternative graphical method of measuring K i ( Figure 4A) (36). At time T after injection of tracer the concentration in the bone ROI, C b (T), is expressed by the following equation:…”

Section: Determination Of Bone Plasma Clearance Using the Patlak Plotmentioning

confidence: 99%

“…In this modified analysis the rate constant k loss is varied until the plot of normalized activity ( Table 3) meets these requirements with little loss of accuracy or precision compared with the standard Hawkins method (36,37). In this alternative method, the AIF is found by measuring the terminal exponential by taking 3 or 4 venous blood samples starting 30 minutes after injection of tracer and adding a population derived residual curve to represent the early bolus peak and fast exponentials ( Figure 4C) (65).…”

Section: Determination Of Bone Plasma Clearance Using the Patlak Plotmentioning

confidence: 99%

Site specific measurements of bone formation using [18F] sodium fluoride PET/CT

Blake¹,

Puri²,

Siddique³

et al. 2018

Quant. Imaging Med. Surg.

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Estimation of regional bone metabolism from whole-body 18F-fluoride PET static images

Abstract: (18)F-Fluoride bone plasma clearance can be estimated from a static scan and venous blood samples acquired 30-60 min after injection. The method enables K ( i ) to be estimated at multiple skeletal sites with a single injection of tracer.

Cited by 44 publications

References 15 publications

18F-NaF PET/CT: EANM procedure guidelines for bone imaging

18F-NaF PET/CT: EANM procedure guidelines for bone imaging

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Site specific measurements of bone formation using [18F] sodium fluoride PET/CT

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