Estimation of plasma lipids and its significance on histopathological grades in oral cancer: Prognostic significance an original research

Sherubin, Eugenia; Kannan, Swati; Kumar, Dhineksh N; Joseph, Isaac

doi:10.4103/0973-029x.110685

Cited by 16 publications

(14 citation statements)

References 19 publications

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“…TG and LDL showed no significant changes. The results obtained in our study are on par with the results of Jyothi Chawda et al, 7 Sherubin EJ et al, 6 Patel PS et al, 10 Mehrotra R et al, 11 Lohe V et al 12 and Nayak P et al 13 and disagreed with the results of Goyal S et al 5 Our results add to the evidence of inverse relationship between lower serum lipid profile in oral cancer and potentially malignant disorders. Although the role of tobacco has been established as an etiological factor for oral cancer and potentially malignant disorders, it may have an indirect and overall significant association with serum lipid profile.…”

Section: Discussioncontrasting

confidence: 56%

“…The enzyme fatty acid synthase and its activity is highly elevated in biosynthetically altered anaplastic cells of poorly differentiated lesions as compared to moderate and well differentiated lesions. 6 However in contrary to afore mentioned statement, we observed the mean serum lipid parameters TC, TG, HDL, LDL, VLDL, showed no significant p value according to degree of differentiation. Similar findings were also obtained in the studies by Jyothi Chawda et al, 7 Kumar P et al 8 and Anuradha et al 9 In the present study, the serum lipid profile parameters like TC, HDL and VLDL showed lower values in PMD and OC groups when compared to control group.…”

Section: Discussioncontrasting

confidence: 54%

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Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

K¹,

Naik²,

Kini³

et al. 2020

JOOO

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Introduction and objectives: Serum lipid profile is used to measure the systemic health status of an individual. The objective of the study was to evaluate and correlate serum lipid profile in patients with potentially malignant disorders, oral cancer and controls. Materials and Methods: This study was conducted on a sample of 150 subjects in which the subjects were divided into three groups with 50 subjects in each group. The subjects in Group I were Controls (CT) Group II were Potentially Malignant Disorder (PMD) and Group III were Oral Cancer (OC). Out of 150 subjects 50 subjects were diagnosed as potentially malignant disorder and 50 were diagnosed as oral cancer based on histopathological diagnosis. Results: When results of group III were compared and correlated to subjects of group I, a decrease in TC, HDL, LDL and VLDL was elicited. When results of group II were compared and correlated to subjects of group I, a decrease in TC, HDL, LDL and VLDL was elicited. Triglycerides, was not significantly altered in the study. Interpretation and Conclusion:The results of our study showed an evidence of an inverse relationship between serum lipid profile and oral cancer and potentially malignant disorders. The lower serum lipid status may be considered as an indicator to reflect the initial changes occurring in neoplastic cells, thus substantiating their use as a diagnostic adjuvant in monitoring the oral cancer and potentially malignant disorder.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 54%

Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

K¹,

Naik²,

Kini³

et al. 2020

JOOO

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show abstract

“…40,41 Sherubin et al observed a significant decrease of all lipid levels in patients with oral malignancy. 42 Alexopolus et al have found non-significant difference in serum triglyceride levels between controls and patients. 13 The results are strengthen by the present study which also shows lower levels of serum levels of total cholesterol, Triglycerides, HDL, VLDL, LDL in oral cancer and precancerous lesion patients.…”

Section: Discussionmentioning

confidence: 95%

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

Singh

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Lower levels of lipid in proliferating tissues and in blood compartments may occur due to ongoing process of oncogenesis. The evidence regarding hypolipidemia as a predisposing factor for malignancy is scarce. Therefore, this study was undertaken to study alteration of plasma lipid levels in patients diagnosed with oral squamous cell carcinoma (OSCC) and its oral pre-cancerous (OPC) lesions and also to compare the plasma lipid profile in different grades of OSCC.Methods: A single centre prospective cross sectional study was carried out among 150 consecutive patients of OSCC and OPC lesions. The diagnosis of all lesions was confirmed histopathologically and grading was also done for each lesion based on degree of differentiation and keratinization of tumour cells. Serum total cholesterol, HDL, TG, LDL was estimated by using semi-automated chemical analyzer. The lipid levels were compared by using unpaired t-test between two strata whereas one way analysis of variance (ANOVA) with Tukey’s post-hoc tests was used among more than two strata. Results: Total cholesterol, TG, HDL, and LDL were significantly reduced in OSCC and OPC groups when compared with the reference values. Serum TC, LDL and HDL levels were found to be decreased with the loss of differentiation in histological grading but with no statistical significance.Conclusions: It can be inferred that there is an inverse relationship between the serum lipid profile values of TC, HDLC, TG, LDL and OSCC as well as OPC patients. The lower serum lipid status may be considered a useful indicator for initial changes occurring in neoplastic cells.

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“…ACAT catalyses the reaction of free cholesterol to esterified cholesterol. It has therefore been hypothesised that lower cholesterol levels in patients with advanced disease may be due to its increased storage in tumour cells and its utilisation for new membrane biosynthesis . It is unknown whether serum cholesterol can be used as a surrogate for tumour cholesterol and whether these serum cholesterol levels pre‐existed or are a consequence of the tumour.…”

Section: Discussionmentioning

confidence: 99%

“…Serum cholesterol is another possible surrogate biomarker of lipid metabolism that is broadly available and routinely assessed in many patients. Although widely used to predict outcomes of patients with coronary heart disease, there are few studies that focus on its role as a prognostic marker in cancer . Ohno et al.…”

Section: Introductionmentioning

confidence: 99%

Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma (RCC)

et al. 2014

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ObjectiveTo assess the prognostic role of preoperative serum cholesterol in patients with renal cell carcinoma (RCC), as increasing evidence suggests that alterations in the lipid profile are associated with the development, progression and prognosis of various cancers. Patients and MethodsWe analysed 867 patients, who underwent radical or partial nephrectomy for RCC between 2002 and 2012. Preoperative total cholesterol levels were determined in serum using colorimetric analysis (CHOD-PAP method). The association with cancer-specific survival (CSS) was assessed with Cox models. Discrimination was quantified with the C-index. The median follow-up was 52 months. ResultsThe median (interquartile range) serum cholesterol was 195 (166-232) mg/dL. Decreasing serum cholesterol was associated with more advanced T, N and M stages (P < 0.001), higher grades (P = 0.001) and presence of tumour necrosis (P = 0.002). Continuously coded cholesterol was associated with CSS in both univariable (hazard ratio [HR] 0.87, P < 0.001) and multivariable analyses (HR 0.93, P = 0.001). The discrimination of a multivariable base model increased significantly from 88.3% to 89.2% following inclusion of cholesterol (P = 0.006). In patients with clinically localised disease (T1-3N0/+M0), cholesterol remained associated with CSS in multivariable analysis (HR 0.90, P = 0.002) and increased the discrimination from 74.6% to 76.9% (P = 0.002). ConclusionsPreoperative serum cholesterol is an independent prognostic factor for patients with RCC, with lower levels being associated with worse survival. Its use increases the discrimination of established prognostic factors. As cholesterol is a broadly available routine marker, its use may provide a meaningful adjunct in clinical practice. The biological rationale underlying this association remains to be clarified.

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Estimation of plasma lipids and its significance on histopathological grades in oral cancer: Prognostic significance an original research

Cited by 16 publications

References 19 publications

Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma (RCC)

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