Estimation of patient effective doses in PET/CT- 18F-Sodium Fluoride examinations

Alnaaimi, M.; Sulieman, Abdelmoneim; Tamam, Nissren; Alkhorayef, M.; Alduaij, M.; Mohammedzein, Talal; Alomair, Othman I.; Alashban, Yazeed; Salah, Hassan; Abd-Elghany, Amr A.; Omer, Hiba; Bradley, D.A.

doi:10.1016/j.apradiso.2021.109965

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Although radiation is not evenly distributed globally, the number of diagnostic nuclear medicine exams yearly is rising [3] [4] [5]. For most NM examinations, the mean effective dose per NM examination ranges from 0.3 to 20.0 mSv [6]- [13]. The development of the 99Mo/99mTc generating set and γ-camera in the 1950s allowed for the performance of bone scanning techniques by clinicians [14] (Stefanofic, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…NM involves handling radioactive substances that can expose staff to radiation both internally and externally as a result of radiopharmaceutical elusions and preparation in specially protected laboratory (hot lab). The staff was also exposed to ionizing radiation for the period of administering 99mTc to patients and after the scanning that poses radiogenic hazard for NM personnel [6] [7] [8] [9]. Therefore, depending on workload and procedure approach, areas of the body not covered with the leaded apron might be exposed to unavoidable exposure resulted from ionizing radiation sources.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Patient and Staff Annual Effective Doses at a Nuclear Medicine Department during Bone Scans

Mattar¹

2022

OJRad

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The current research aims to assess the staff and patients' effective doses during Nuclear medicine (NM) bone scans procedures. The administered activity was utilized to quantify the patients' effective doses, while personnel's effective doses were quantified using thermoluminescent detectors (TLD-100). The average administered activity was 650 (440 to 1440) MBq procedures using SPECT gamma camera system. The average annual staff effective dose (mSv) was estimated to be 2.3 (0.1 to 4.9). The typical patient's effective dose was 4.9 (3.6 to 6.0) mSv per procedure. Staff exposure within the yearly effective dose limits. Patients' exposure optimization is required based on patient weight. Estimating staff eye lens doses is suggested to confirm that the yearly effective radiation doses are within the safety range.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Patient and Staff Annual Effective Doses at a Nuclear Medicine Department during Bone Scans

Mattar¹

2022

OJRad

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“…7,8 Recently, in addition to oncologic applications, the diagnostic potential of NaF-PET in monitoring benign bone diseases has been increasingly appreciated. 5,[9][10][11] Although the radiation exposure from NaF-PET/CT (effective dose up to 10 mSv 12 ) is greater than that of dualenergy x-ray absorptiometry (DXA; effective dose up to 0.01 mSv 13 ) and quantitative CT (effective dose up to 3 mSv 13 ), a validated method of using NaF-PET/CT to evaluate metabolic bone disease could facilitate more opportunities for osteoporosis screening among patients undergoing imaging for cancer staging or restaging. Furthermore, clinical trials of novel therapeutic agents that aim to modulate osteoblastic activity to treat metabolic bone disease require precise and accurate metrics to characterize drug effects.…”

mentioning

confidence: 99%

The Utility of 18F-NaF-PET/CT in Measuring the Metabolic Activity of Aging Spine

Park

Resto

Khurana

et al. 2023

Spine

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Study Design. Cross-sectional; observational. Objectives. To determine whether sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) can be used to monitor decreased bone turnover with aging in the spine. Background. Osteoporosis is characterized by structural changes in the bone such as decreased bone mineral density leading to an increased risk for fractures. An imaging modality capable of identifying molecular changes that precede these structural changes could be critical for the early diagnosis and monitoring of osteoporosis and other metabolic bone disorders. Materials and Methods. The potential of 18F-sodium fluoride (NaF)–PET/CT in detecting changes in bone turnover associated with aging was examined in the lumbar spine of 88 healthy volunteers (43 females, 45 males; mean age 44.6 yr). Regions of interest equal to the trabecular body of the L1 to L4 vertebrae were used to calculate the mean standardized uptake value (SUVmean) and average Hounsfield unit (HU) values. Receiver-operating characteristic curve analysis with an area under the curve using the Wilson/Brown method was generated to assess the value of NaF uptake (SUVmean) in predicting osteoporosis as defined by HU-threshold values. To determine the correlation among global SUVmean, mean HU values, and age, the Spearman correlation test was performed on images acquired at 90 minutes postinjection. Results. There was a significant negative correlation between NaF SUVmean and age in females (P < 0.0001, r = −0.59), and a weaker, but also significant correlation in males (P = 0.03, r = −0.32). In females only, there was a significant correlation between NaF uptake and age at all acquisition time points. Measured NaF uptake increased by 10% to 15% with acquisition time in both sexes, from 45 to 90 minutes and from 90 to 180 minutes. Conclusions. NaF-PET/CT detects decreased vertebral bone turnover with aging, particularly in females. Measured NaF uptake increased with PET acquisition time after tracer injection, which must be considered in follow-up studies monitoring disease development and treatment effects.

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Deriving local diagnostic reference levels for four common adult PET/CT procedures in a Saudi Arabian hospital

Alkhybari

Alhulail

Sulieman

et al. 2022

Journal of Radiation Research and Applied Sciences

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Estimation of patient effective doses in PET/CT- 18F-Sodium Fluoride examinations

Cited by 6 publications

References 20 publications

Assessment of Patient and Staff Annual Effective Doses at a Nuclear Medicine Department during Bone Scans

Assessment of Patient and Staff Annual Effective Doses at a Nuclear Medicine Department during Bone Scans

The Utility of 18F-NaF-PET/CT in Measuring the Metabolic Activity of Aging Spine

Deriving local diagnostic reference levels for four common adult PET/CT procedures in a Saudi Arabian hospital

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