Methods developed for radial basis function network (RBFN) identification are applied to a complex multiple-input, multiple-output (MIMO) simulation of a solution copolymerization reactor. For RBFN identification, k-means clustering and stepwise regression analysis are used. The practicality of applying these methods to large industrial identification problems is discussed, considering the restrictions of industrially practical input sequence design. The RBFN model has three inputs and two outputs, and the dimensionality of the identification problem poses some difficulties for nonlinear empirical model identification; specifically, the large amount of data required is a problem for plant testing and may cause computational difficulties for identification algorithms as well.