Estimation of Nonlinear Elasticity Parameter of Tissues by Ultrasound

Nitta, Naotaka; Shiina, Tsuyoshi

doi:10.1143/jjap.41.3572

Cited by 30 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the Young's modulus of the tissue phantoms measured in this study is comparable to that reported in [60] (20 to 30 kPa). The Young's modulus of the ex vivo kidney cortex is comparable to results from [61]- [63] (20 to 40 kPa), although higher than results from [64], [65] (7 to 15 kPa). Measurement errors in the Young's modulus reported here may occur because of violations of assumptions in (1), i.e., the medium being isotropic, non-dispersive, and locally homogeneous.…”

Section: Discussionsupporting

confidence: 54%

Imaging feedback of histotripsy treatments using ultrasound shear wave elastography

Wang

Hall

et al. 2012

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

Histotripsy is a cavitation-based ultrasound therapy that mechanically fractionates soft solid tissues into fluid-like homogenates. This paper investigates the feasibility of imaging the tissue elasticity change during the histotripsy process as a tool to provide feedback for the treatments. The treatments were performed on agar tissue phantoms and ex vivo kidneys using 3-cycle ultrasound pulses delivered by a 750-kHz therapeutic array at peak negative/positive pressure of 17/108 MPa and a repetition rate of 50 Hz. Lesions with different degrees of damage were created with increasing numbers of therapy pulses from 0 to 2000 pulses per treatment location. The elasticity of the lesions was measured with ultrasound shear wave elastography, in which a quasiplanar shear wave was induced by acoustic radiation force generated by the therapeutic array, and tracked with ultrasound imaging at 3000 frames per second. Based on the shear wave velocity calculated from the sequentially captured frames, the Young's modulus was reconstructed. Results showed that the lesions were more easily identified on the shear wave velocity images than on Bmode images. As the number of therapy pulses increased from 0 to 2000 pulses/location, the Young's modulus decreased exponentially from 22.1 ± 2.7 to 2.1 ± 1.1 kPa in the tissue phantoms (R 2 = 0.99, N = 9 each), and from 33.0 ± 7.1 to 4.0 ± 2.5 kPa in the ex vivo kidneys (R 2 = 0.99, N = 8 each). Correspondingly, the tissues transformed from completely intact to completely fractionated as examined via histology. A good correlation existed between the lesions' Young's modulus and the degree of tissue fractionation as examined with the percentage of remaining structurally intact cell nuclei (R 2 = 0.91, N = 8 each). These results indicate that lesions produced by histotripsy can be detected with high sensitivity using shear wave elastography. Because the decrease in the tissue elasticity corresponded well with the morphological and histological change, this study provides a basis for predicting the local treatment outcomes from tissue elasticity change.

show abstract

Section: Discussionsupporting

confidence: 54%

Imaging feedback of histotripsy treatments using ultrasound shear wave elastography

Wang

Hall

et al. 2012

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

show abstract

“…Since the 2000s, this focus has shifted to parameters that express the nonlinear material behavior of biological tissues, such as nonlinear elasticity, hyperelasticity and viscoelasticity. Some researchers [6], including Hall et al [7] and Mehrabian et al [8,9], have applied ultrasound and finite element inverse analysis to determine the elastic nonlinearity under large strains (around 10 % axial strain). Additionally, many researchers have reported dynamic multifrequency elastography for viscoelastic imaging using MRI and external oscillation devices [10][11][12].…”

Section: Noninvasive Breast Cancer Diagnosismentioning

confidence: 99%

Automated palpation for breast tissue discrimination based on viscoelastic biomechanical properties

et al. 2014

View full text Add to dashboard Cite

show abstract

“…30 Erkamp et al and Nitta and Shiina investigated measurement of the nonlinear relationship between strain and applied stress. 31,32 In the present study, a method for assessing the nonlinear property in the stress-strain relationship of the artery wall was investigated. For this purpose, external cyclic actuation was applied from the skin surface on the brachial artery.…”

Section: Introductionmentioning

confidence: 99%