Estimation of microcystins in the freshwater fish <i>Oreochromis niloticus</i> in an Egyptian fish farm containing a <i>Microcystis</i> bloom

Mohamed, Zainal Abidin; Carmichael, Wayne W.; Hussein, Ahmed

doi:10.1002/tox.10111

Cited by 189 publications

(127 citation statements)

References 32 publications

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“…In hybrid sturgeon, MCs concentration in liver of fish fed low level cyanobacteria diet was more than 400 ng/g DW after a 47-day MCs exposure. Compared with the concentrations reported in natural MCs accumulation in fish liver of different species, the present levels were lower (Magalhães et al, 2001;Deblois et al, 2008) or in the same range (Mohamed et al, 2003;Zhao et al, 2006). According to our results, high levels of MCs could be accumulated in fish tissue both at the low level and the high level cyanobacteria diets.…”

Section: Microcystins Accumulation and Depuration In Fish Tissuecontrasting

confidence: 63%

“…Previous studies demonstrated that cyanobacterial exposure through the gastrointestinal system was toxic to many fish species such as rainbow trout (Tencalla et al, 1996), common carp , silver carp (Xie et al, 2007), and tilapia (Mohamed et al, 2003;Mohamed and Hussein, 2006). Previous studies reported that fish exposed to or feeding on toxic cyanobacterial cells showed a reduced growth (Bury et al, 1995;Kamjunke et al, 2002a,b).…”

Section: Effect Of Dietary Cyanobacteria On Fish Growth and Feed Utilmentioning

confidence: 99%

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Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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A 90-day growth trial was conducted on hybrid sturgeon (Acipenser baeri $ 3 A. gueldenstaedtii #) to investigate the effect of dietary inclusion of cyanobacteria on growth, feed utilization, and fish tissue microcystins (MCs) accumulation and the recovery of fish when they were free of cyanobacteria. Four diets were formualted isonitrogenous and isocaloric to contain different MCs concentrations: the control diet (free of cyanobacteria), low cyanobacteria diet (LCD, 26.60 lg MCs/g diet), medium cyanobacteria diet (MCD, 78.82 lg MCs/g diet), and high cyanobacteria diet (HCD, 201.03 lg MCs/g diet). During the first 47 days, each diet was fed to fish in five replicates and then all fish were fed the control diet during the next 43 days. The results showed that a dose-dependent decrease in feeding rate (FR) and specific growth rate (SGR) were observed in the fish fed with MCD and HCD. MCs contents in fish liver, intestine, and dorsal white muscle increased with dietary MCs and were time dependent (P \ 0.05). After the 43-day recovery, there were no significant differences in FR or SGR between the fish previously fed LCD or MCD and the fish fed with the control diet (P [ 0.05), while the fish previously fed HCD showed higher FR and SGR than those fed the control diet (P \ 0.05). MCs clearance in fish liver and intestine showed time-dependence during the 43-day recovery. # 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 161-170, 2011.

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Section: Microcystins Accumulation and Depuration In Fish Tissuecontrasting

confidence: 63%

Section: Effect Of Dietary Cyanobacteria On Fish Growth and Feed Utilmentioning

confidence: 99%

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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“…Therefore, MCs have huge potential risks to human health. The outbreaks of poisoning effects on animals and humans induced by toxic cyanobacteria have been reported in many countries (Mohamed et al 2003;Yokoyama and Park 2002;Chen and Xie 2005;Falconer et al 1983;Ibelings et al 2005).…”

Section: Introductionmentioning

confidence: 99%

A review of neurotoxicity of microcystins

Chen

Fan

et al. 2016

Environ Sci Pollut Res

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Cyanobacterial blooms-produced microcystins are secondary metabolites which can accumulate in the food chain and contaminate water, thus posing a potential threat to the health of aquatic animals and even humans. Microcystin toxicity affects not only the liver but also the other organs, i.e., the brain. The serious neurotoxicity effects caused by microcystins then lead to various symptoms. This review focuses on the neurotoxicity of microcystins. Microcystins can cross bloodbrain barrier with the transport of Oatps/OATPs, causing neurostructural, functional, and behavioral changes. In this review, potential uptake mechanisms and neurotoxicity mechanisms are summarized, including neurotransmissions, neurochannels, signal transduction, oxidative stress, and cytoskeleton disruption. However, further researches are needed for detailed studies on signaling pathways and the downstream pathways of neurotoxicity of microcystins.

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“…In the natural environment, MCs accumulate in a wide range of aquatic animals, including fish (Magalhães et al, 2003;Mohamed et al, 2003), shrimps (Chen and Xie, 2005b), gastropods (Chen and Xie, 2005b;Zhang et al, 2012;Zurawell et al, 1999) and bivalves (Chen and Xie, 2005a;Williams et al, 1997). MCs are found in both the viscera and also in the edible muscle/foot.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Jia

Luo

Lü

et al. 2014

Science of The Total Environment

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Microcystins (MCs) are the toxic products of harmful algal blooms and they accumulate in fish. The accumulation of MCs in fish living in different trophic levels from different parts of Lake Taihu was determined. This information was then used to evaluate the risks posed by the MCs in fish to human health. The concentrations of three MCs, MC-LR, MC-YR and MC-RR, were quantified in the following four fish species: silver carp (Hypophthalmichthys molitrix), bighead carp (Aristichthys nobilis), crucian carp (Carassius auratus) and common carp (Cyprinus carpio), using high performance liquid chromatography interfaced with tandem (triple quadrupole) mass spectrometry. The mean concentrations of MCs in the muscle, the kidney, the intestinal wall and the heart were significantly different among the four fishes except in the liver. C. carpio contained the highest mean concentration of MCs in the muscle (31.7 ± 12.1 ng/g, dry mass (dm)), whereas C. auratus had the highest mean concentrations of MCs in the liver (45.4 ± 44.5 ng/g, dm), kidney (114 ± 51.1 ng/g, dm), intestinal wall (2.04 × 10 3 ± 4.43 × 10 3 ng/g, dm) and heart (59.5 ± 26.7 ng/g, dm). The mean concentration of MCs in the intestinal walls of the fish species was significantly higher than in other organs (p b 0.01). The fish from Meiliang Bay had significantly higher concentrations of MCs than those from the centre, west or south banks of the lake (p b 0.01). The body lengths and masses of the fish were negatively correlated with the concentrations of MCs in the kidney (p b 0.05) and heart (p b 0.01). The average daily intake (ADI) of MCs in the muscle of all fishes exceeded the provisional tolerable daily intake (TDI) set by World Health Organization. The estimated daily intakes of MCs in 55.6% of the muscle samples exceeded the TDI. The MCs in the tissues of the fish from Lake Taihu pose potential risks to the health of humans who consume these four fish species.

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Estimation of microcystins in the freshwater fish Oreochromis niloticus in an Egyptian fish farm containing a Microcystis bloom

Cited by 189 publications

References 32 publications

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

A review of neurotoxicity of microcystins

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

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