Estimation of mechanical properties of a viscoelastic medium using a laser-induced microbubble interrogated by an acoustic radiation force

Yoon, Sangpil; Aglyamov, Salavat R.; Karpiouk, Andrei; Kim, Seung-Soo; Emelianov, Stanislav

doi:10.1121/1.3628344

Cited by 20 publications

(35 citation statements)

References 55 publications

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“…In Ref. 23, the properties were compared with literature values measured at different frequencies 24,25 and the samples used in the experiments were not characterised independently using standard rheological methods.…”

Section: Introductionmentioning

confidence: 99%

High-frequency linear rheology of hydrogels probed by ultrasound-driven microbubble dynamics

et al. 2017

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Ultrasound-driven microbubble dynamics are central to biomedical applications, from diagnostic imaging to drug delivery and therapy. In therapeutic applications, the bubbles are typically embedded in tissue, and their dynamics are strongly affected by the viscoelastic properties of the soft solid medium. While the behaviour of bubbles in Newtonian fluids is well characterised, a fundamental understanding of the effect on ultrasound-driven bubble dynamics of a soft viscoelastic medium is still being developed. We characterised the resonant behaviour in ultrasound of isolated microbubbles embedded in agarose gels, commonly used as tissue-mimicking phantoms. Gels with different viscoelastic properties were obtained by tuning agarose concentration, and were characterised by standard rheological tests. Isolated bubbles (100-200 µm) were excited by ultrasound (10-50 kHz) at small pressure amplitudes (< 1 kPa), to ensure that the deformation of the material and the bubble dynamics remained in the linear regime. The radial dynamics of the bubbles were recorded by high-speed video microscopy. Resonance curves were measured experimentally and fitted to a model combining the Rayleigh-Plesset equation governing bubble dynamics, with the Kelvin-Voigt model for the viscoelastic medium. The resonance frequency of the bubbles was found to increase with increasing shear modulus of the medium, with implications for optimisation of imaging and therapeutic ultrasound protocols. In addition, the viscoelastic properties inferred from ultrasound-driven bubble dynamics differ significantly from those measured at low frequency with the rheometer. Hence, rheological characterisation of biomaterials for medical ultrasound applications requires particular attention to the strain rate applied.

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Section: Introductionmentioning

confidence: 99%

High-frequency linear rheology of hydrogels probed by ultrasound-driven microbubble dynamics

et al. 2017

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“…Reconstruction of the viscoelastic properties of the porcine vitreous humors using the microbubble approach was performed by finding the best fit between microbubble displacement profiles measured in the experiments and calculated by theory [23], [24], [26], [30]–[32]. The measurements of the microbubble’s displacements were repeated three times using a single microbubble at each location.…”

Section: Methodsmentioning

confidence: 99%

“…We advanced the microbubble-based acoustic radiation force technique by combining the theoretical model and experimental measurements [22]–[29]. Importantly, the dynamic approach does not require the knowledge of the acoustic radiation force magnitude to reconstruct viscoelastic properties of a medium [24], [30]. We have also developed the high-pulse-repetition-frequency (PRF) ultrasound system which improved the accuracy of the microbubble displacement measurements [31].…”

Section: Introductionmentioning

confidence: 99%

“…We have also developed the high-pulse-repetition-frequency (PRF) ultrasound system which improved the accuracy of the microbubble displacement measurements [31]. In our previous work, we validated our theoretical model [23] of the dynamics of rounded objects such as solid spheres [24], [26] and laser-induced microbubbles [30] under acoustic radiation force in a viscoelastic medium. The approach has been implemented using a high-PRF ultrasound system and applied successfully in the measurement of the viscoelastic properties of animal crystalline lenses of different ages and species [31], [32].…”

Section: Introductionmentioning

confidence: 99%

“…The displacements of the microbubbles were measured by a custom-built high-PRF ultrasound system [31]. Reconstruction of the viscoelastic properties of the vitreous was performed by comparing microbubble displacements obtained by experimental measurements to theoretical calculations [30]–[32]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Correspondence: spatial variations of viscoelastic properties of porcine vitreous humors

Yoon

Aglyamov

Karpiouk

et al. 2013

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Using a microbubble-based acoustic radiation force approach, spatial variations of Young’s modulus and shear viscosity of the porcine vitreous humors in two groups— young pigs (6 months old) and mature pigs (2 to 3 years old)— were measured in situ. The measurements in these groups (4 specimens in each group) were performed in several positions along an anterior-to-posterior direction. At each position, microbubbles were generated by focusing a nanosecond pulsed laser beam and the displacement of each microbubble in response to an impulsive acoustic radiation force was measured every 10 μs using a custom-made high-pulse-repetition-frequency ultrasound system. Based on measured dynamics of the microbubble, Young’s modulus and shear viscosity at various locations of the vitreous were reconstructed. Young’s moduli of the young and mature porcine vitreous at anterior region were the highest, whereas the central region had the lowest values, indicating the clear spatial variations in the vitreous humor elasticity in both groups.

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A New Approach for Measuring Viscoelastic Properties of Soft Materials Using the Dynamic Response of a Spherical Object Placed at the Sample Interface

Koruk,

Koc,

Yurdaer

et al. 2023

Exp Mech

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Background There are several techniques to characterize the mechanical properties of soft materials, such as the indentation method and the method based on the application of a spherical object placed inside the sample. The indentation systems usually yield the elastic properties of materials and their mathematical models do not consider the inertia of the sample involved in motion and radiation damping, while placing an object inside the sample is not practical and this procedure can alter the mechanical properties of the sample for the method based on the application of a bubble/sphere placed inside the sample. Objective A new approach for the identification of the viscoelastic properties of soft materials using the dynamic response of a spherical object placed at the sample interface was proposed. Methods The spherical object placed at the sample interface was pressed using an electromagnet and the dynamic response of the spherical object was tracked using a high-speed camera, while the dynamic response of the spherical object placed at the sample interface was estimated using a comprehensive analytical model. The effects of the shear modulus, viscosity, Poisson’s ratio and density of the soft sample, the radius and density of the spherical object and the damping due to radiation were considered in this mathematical model. The shear modulus and viscosity of the soft sample were determined by matching the experimentally identified and theoretically estimated responses of the spherical object. Results The shear moduli and viscosities of the three phantoms with the gelatin mass ratios of 0.20, 0.25 and 0.29 were measured to be 3450, 4300 and 4950 Pa and 12.5, 14.0 and 15.0 Pa⋅s, respectively. The shear modulus and viscosity of the phantom increases as the gelatin mass ratio increases. The frequency of oscillations of the hemisphere placed at the phantom interface increases as the gelatin mass ratio increases due to stiffness increase. Conclusions After matching the experimental and theoretical steady-state displacements and amplitudes of oscillations of the hemisphere at the sample interface, the comparison of the experimentally identified and theoretically predicted frequency of oscillations further confirmed the identified material properties of the samples. The approach presented here is expected to provide valuable information on material properties in biomedical and industrial applications.

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Estimation of mechanical properties of a viscoelastic medium using a laser-induced microbubble interrogated by an acoustic radiation force

Cited by 20 publications

References 55 publications

High-frequency linear rheology of hydrogels probed by ultrasound-driven microbubble dynamics

High-frequency linear rheology of hydrogels probed by ultrasound-driven microbubble dynamics

Correspondence: spatial variations of viscoelastic properties of porcine vitreous humors

A New Approach for Measuring Viscoelastic Properties of Soft Materials Using the Dynamic Response of a Spherical Object Placed at the Sample Interface

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