Estimation of life expectancies and loss-of-life expectancies for workers with permanent occupational disabilities of the extremities – a 21-year follow-up study

Lin, Sheng‐Hsuan; Lee, Hsin Yi; Chang, Yu Yin; Jang, Yuh; Wang, Jung‐Der

doi:10.5271/sjweh.3194

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…rauma remains the number one cause of years of lost life and extremities are the most commonly injured anatomic sites 1,2 . After extremity trauma, an inflammatory response is mounted at the site of injury that promotes wound healing and regeneration of involved musculoskeletal tissues.…”

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confidence: 99%

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

et al. 2020

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Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes. Despite frequent cases of hospitalized musculoskeletal trauma, the inflammatory responses and cell population dynamics that regulate subsequent wound healing and tissue regeneration are still unclear. Here we examine, using a mouse model of trauma-induced HO, the local microenvironment of the initial post-injury inflammatory response. Single cell transcriptome analyses identify distinct monocyte/macrophage populations at the injury site, with their dynamic changes over time elucidated using trajectory analyses. Mechanistically, transforming growth factor beta-1 (TGFβ1)-producing monocytes/macrophages are associated with HO and aberrant chondrogenic progenitor cell differentiation, while CD47-activating peptides that reduce systemic macrophage TGFβ levels and help ameliorate HO. Our data thus implicate CD47 activation as a therapeutic approach for modulating monocyte/macrophage phenotypes, MSC differentiation and HO formation during wound healing.

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confidence: 99%