Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer

Fukahori, Mai; Matsufuji, Naruhiro; Himukai, Takeshi; Kanematsu, Nobuyuki; Mizuno, Hideyuki; Fukumura, Akifumi; Tsuji, Hiroshi; Kamada, Tadashi

doi:10.1016/j.radonc.2015.11.023

Cited by 20 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastrointestinal (GI) complications were scored according to the GI disorders terms of the CTCAE. In Fukahori et al [16], GI complications were scored according to the guidelines of the Radiation therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) [27]. With the aim of applying NIRS NTCP parameters to CNAO rectum DVHs, the toxicity originally reported according to CTCAE was re-scored for this analysis using the RTOG scale.…”

Section: Patient Treatment and Follow-upmentioning

confidence: 99%

“…From D MKM distributions, the FRoG generated EUD values to predict the late rectal toxicity NTCP, based upon the formulation reported by Fukahori et al [16,29,30]. In particular, the median values for LKB parameters n, m and TD50 (0.035 (95% CI: 0.024-0.047), 0.10 (0.084-0.13) and 63.6 Gy(RBE) (61.8-65.4)) obtained for ≥G1 late rectal toxicity were selected to calculate the NTCP for the CNAO population.…”

Section: Dose Recalculation and Analysismentioning

confidence: 99%

“…Despite well-known differences in the two RBE systems outside the target volume, CNAO is following a conservative approach, by prudentially adopting rectum constraints from the experience acquired through NIRS [14,15]. The late rectal toxicity of prostate AdC patients treated at NIRS was recently reported and fitted to the Lyman-Kutcher-Burman (LKB) NTCP model [16]. Additionally, a new study showed that the dose to 2 cc of the rectum volume (D 2cc ) could represent a good predictor of CIRT rectal damage [17].…”

Section: Introductionmentioning

confidence: 99%

“…In this work, FRoG was used to compute and analyze differences between LEM and mMKM RBE-weighted dose distribution (D RBE ) to the rectum for prostate AdC and sacral chordoma patients previously treated at CNAO. In parallel, we analyzed clinical outcomes from CNAO in relation to the NIRS rectum toxicity, and applied the NIRS NTCP model [16] to evaluate the expected probability of late rectal damage based on a patient cohort with a longer follow-up period. The main aim was to establish and propose updated LEM-based planning constraints for safe clinical application, correcting the over-conservative approach adopted since the beginning of clinical activity at CNAO.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rectum Dose Constraints for Carbon Ion Therapy: Relative Biological Effectiveness Model Dependence in Relation to Clinical Outcomes

Choi

Molinelli

Russo

et al. 2019

Cancers

View full text Add to dashboard Cite

The clinical application of different relative biological effectiveness (RBE) models for carbon ion RBE-weighted dose calculation hinders a global consensus in defining normal tissue constraints. This work aims to update the local effect model (LEM)-based constraints for the rectum using microdosimetric kinetic model (mMKM)-defined values, relying on RBE translation and the analysis of long-term clinical outcomes. LEM-optimized plans of treated patients, having suffered from prostate adenocarcinoma (n = 22) and sacral chordoma (n = 41), were recalculated with the mMKM using an in-house developed tool. The relation between rectum dose-volume points in the two RBE systems (DLEM|v and DMKM|v) was fitted to translate new LEM-based constraints. Normal tissue complication probability (NTCP) values, predicting late rectal toxicity, were obtained by applying published parameters. No late rectal toxicity events were reported within the patient cohort. The rectal toxicity outcome was confirmed using dosimetric analysis: DMKMVHs lay largely below original constraints; the translated DLEM|v values were 4.5%, 8.3%, 18.5%, and 35.4% higher than the nominal DMKM|v of the rectum volume, v—1%, 5%, 10% and 20%. The average NTCP value ranged from 5% for the prostate adenocarcinoma, to 0% for the sacral chordoma group. The redefined constraints, to be confirmed prospectively with clinical data, are DLEM|5cc ≤ 61 Gy(RBE) and DLEM|1cc ≤ 66 Gy(RBE).

show abstract

Section: Patient Treatment and Follow-upmentioning

confidence: 99%

Section: Dose Recalculation and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rectum Dose Constraints for Carbon Ion Therapy: Relative Biological Effectiveness Model Dependence in Relation to Clinical Outcomes

Choi

Molinelli

Russo

et al. 2019

Cancers

View full text Add to dashboard Cite

show abstract

“…Proton and carbon ion radiotherapy have gained great attention in recent years and have been used for different tumor sites [1][2][3][4] . Compared with photon radiotherapy, proton and carbon ion radiotherapy can provide a higher target dose while allowing better sparing of normal tissue due to the depth dose distribution, low entrance dose followed by the Braggpeak [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a verification method for proton and carbon ion radiotherapy plan delivery accuracy check

Jun

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background All plan verification systems available for particle therapy are designed for pre-treatment verification. The plan delivery accuracy during treatment are unknown. The purpose of this study is to introduce a verification method and develop a software for proton and carbon ion plan delivery accuracy check. Methods A program was developed using Matlab to reconstruct dose from beam parameters recorded in log files and compare the dose reconstructed with the dose calculated by treatment planning system (TPS). Ten carbon ion plans and ten proton plans were enrolled in this study for algorithm validation, sensitivity analysis and plan delivery verification. The dose reconstruction algorithm was validated by comparing the dose calculated by TPS with reconstructed dose using the same beam parameters. The sensitivity of gamma pass rate to spot size deviation, position deviation and particle number deviation were analyzed by comparing dose reconstructed from pseudo plans which have manually added errors with original plan dose. Then plan delivery verification using homemade software were done for the 20 actual treated plans. Results A program for plan delivery verification was developed. For the validation of dose reconstruction algorithm, the mean dose difference between reconstructed dose and plan dose were 0.70% ± 0.24% and 0.51% ± 0.25% for carbon ion and proton plans, respectively. According to our simulation, the Gamma pass rate of carbon ion beam is more sensitive to spot position deviation and particle number deviation, and the Gamma pass rate of proton beam is more sensitive to spot size deviation. For the actual plan delivery verification using homemade software, the mean gamma pass rate were 99.47% ± 0.48%, 99.36% ± 0.50% and 99.48% ± 0.50% for carbon ion beams and 99.92% ± 0.13%, 99.96% ±0.06% and 99.89% ±0.13% for proton beams at three different depth of high dose region using 3mm/3% criteria. Conclusions A software was programed and the algorithm was verified. The method we introduced and the software we made for plan delivery verification is feasible and reliable. The verification method presented in this study can be easily repeated in other hospital.

show abstract

Individual response of humans to ionising radiation: governing factors and importance for radiological protection

Applegate

Rühm

Wójcik

et al. 2020

Radiat Environ Biophys

View full text Add to dashboard Cite

Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer

Cited by 20 publications

References 34 publications

Rectum Dose Constraints for Carbon Ion Therapy: Relative Biological Effectiveness Model Dependence in Relation to Clinical Outcomes

Rectum Dose Constraints for Carbon Ion Therapy: Relative Biological Effectiveness Model Dependence in Relation to Clinical Outcomes

Feasibility study of a verification method for proton and carbon ion radiotherapy plan delivery accuracy check

Individual response of humans to ionising radiation: governing factors and importance for radiological protection

Contact Info

Product

Resources

About