Estimation of Inhalation Exposure on the Basis of Airborne Nanomaterial Release Data and Propagation Modeling

Göhler, Daniel; Gritzki, Ralf; Rösler, Markus; Felsmann, Clemens

doi:10.1021/acssuschemeng.8b01678

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Accordingly, presented data are representative for steady state conditions either for air supply or for aerosol supply. Computing of aerosol propagation on the basis of different transport equations for air/carbon dioxide and aerosol as performed for example by Göhler et al 28 , 39 can significantly improve the model.…”

Section: Discussionmentioning

confidence: 99%

Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Göhler

Geldner

Gritzki

et al. 2021

Sci Rep

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Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models. To study drug aerosol supply/deposition, computed tomography scans of a rat capnoperitoneum were used to deduce a virtual and a physical phantom of the rat capnoperitoneum (RCP). RCP qualification was performed for a specific PIPAC method, where the capnoperitoneum is continuously purged by the drug aerosol. In this context, also in-silico analyses by computational fluid dynamic modelling were conducted on the virtual RCP. The physical RCP was used for ex-vivo granulometric analyses concerning drug deposition. Results of RCP qualification show that aerosol deposition in a continuous purged rat capnoperitoneum depends strongly on the position of the inlet and outlet port. Moreover, it could be shown that the droplet size and charge condition of the drug aerosol define the deposition efficiency. In summary, the developed virtual and physical RCP enables detailed in-silico and ex-vivo analyses on drug supply/deposition in rodents.

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Section: Discussionmentioning

confidence: 99%

Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Göhler

Geldner

Gritzki

et al. 2021

Sci Rep

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“…Data analysis was performed by means of professional statistics software (SPSS V26.0, IBM Corp). Data are presented as median (minimum/maximum range) and boxplots (median and interquartile range [IQR] ¼ Q3 e Q1) of particle number concentrations in number of particles per cm 3…”

Section: Discussionmentioning

confidence: 99%

“…Exposure of surgical staff in operating room facilities to surgically induced aerosols, which are released during surgical procedures such as high-frequency electrosurgery and ultrasonic cutting (USC), represents a potential health risk. 1 , 2 Fractions of released aerosols can reach the breathing zone of healthcare workers, 3 especially when they are close to the surgical field. In a survey among operating room facility healthcare workers in the US, 99% of the responders reported being within 5 feet (1.52 m) from the aerosol source.…”

mentioning

confidence: 99%

Experimental Model to Test Electrostatic Precipitation Technology in the COVID-19 Era: A Pilot Study

Buggisch¹,

Göhler

Pape³

et al. 2020

Journal of the American College of Surgeons

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BACKGROUND: In the COVID-19 crisis, laparoscopic surgery is in focus as a relevant source of bioaerosol release. The efficacy of electrostatic aerosol precipitation (EAP) and continuous aerosol evacuation (CAE) to eliminate bioaerosols during laparoscopic surgery was verified. STUDY DESIGN: Ex-vivo laparoscopic cholecystectomies (LCs) were simulated AE EAP or CAE in Pelvitrainer equipped with swine gallbladders. Release of bioaerosols was initiated by performing highfrequency electrosurgery with a monopolar electro hook (MP-HOOK) force at 40 watts (MP-HOOK40) and 60 watts (MP-HOOK60), as well as by ultrasonic cutting (USC). Particle number concentrations (PNC) of arising aerosols were analyzed with a condensation particle counter (CPC). Aerosol samples were taken within the Pelvitrainer close to the source, outside the Pelvitrainer at the working trocar, and in the breathing zone of the surgeon. RESULTS: Within the Pelvitrainer, MP-HOOK40 (6.4 Â 10 5 cm-3) and MP-HOOK60 (7.3 Â 10 5 cm-3) showed significantly higher median PNCs compared to USC (4.4 Â 10 5 cm-3) (p ¼ 0.001). EAP led to a significant decrease of the median PNCs in all 3 groups. A high linear correlation with Pearson correlation coefficients of 0.852, 0.825, and 0.759 were observed by comparing MP-HOOK40 (AE EAP), MP-HOOK60 (AE EAP), and USC (AE EAP), respectively. During ex-vivo LC and CAE, significant bioaerosol contaminations of the operating room occurred. Ex-vivo LC with EAP led to a considerable reduction of the bioaerosol concentration. CONCLUSIONS: EAP was found to be efficient for intraoperative bioaerosol elimination and reducing the risk of bioaerosol exposure for surgical staff.

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“…These measurements confirm the release of ENM in the laboratory, although the real exposure of the worker is often unknown. Moreover, every laboratory is different and there are several parameters to consider, such as the geometry of the room and the ventilation [88,89]. To overcome this lack of data, theoretical models and simulations can be helpful [88,89].…”

Section: Exposurementioning

confidence: 99%

“…Moreover, every laboratory is different and there are several parameters to consider, such as the geometry of the room and the ventilation [88,89]. To overcome this lack of data, theoretical models and simulations can be helpful [88,89].…”

Section: Exposurementioning

confidence: 99%

NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities

et al. 2021

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Research in nanoscience continues to bring forward a steady stream of new nanomaterials and processes that are being developed and marketed. While scientific committees and expert groups deal with the harmonization of terminology and legal challenges, risk assessors in research labs continue to have to deal with the gap between regulations and rapidly developing information. The risk assessment of nanomaterial processes is currently slow and tedious because it is performed on a material-by-material basis. Safety data sheets are rarely available for (new) nanomaterials, and even when they are, they often lack nano-specific information. Exposure estimations or measurements are difficult to perform and require sophisticated and expensive equipment and personal expertise. The use of banding-based risk assessment tools for laboratory environments is an efficient way to evaluate the occupational risks associated with nanomaterials. Herein, we present an updated version of our risk assessment tool for working with nanomaterials based on a three-step control banding approach and the precautionary principle. The first step is to determine the hazard band of the nanomaterial. A decision tree allows the assignment of the material to one of three bands based on known or expected effects on human health. In the second step, the work exposure is evaluated and the processes are classified into three “nano” levels for each specific hazard band. The work exposure is estimated using a laboratory exposure model. The result of this calculation in combination with recommended occupational exposure limits (rOEL) for nanomaterials and an additional safety factor gives the final “nano” level. Finally, we update the technical, organizational, and personal protective measures to allow nanomaterial processes to be established in research environments.

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Estimation of Inhalation Exposure on the Basis of Airborne Nanomaterial Release Data and Propagation Modeling

Cited by 6 publications

References 25 publications

Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Experimental Model to Test Electrostatic Precipitation Technology in the COVID-19 Era: A Pilot Study

NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities

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