Abstract:Abstract. X-ray computed tomography (CT) images are used for diagnostic and therapeutic purposes in various medical disciplines. In Japan, the number of facilities that own diagnostic CT equipment, the number of CT examinations and the number of CT scanners increased by ~1.4-fold between 2005 and 2011. CT operators (medical radiological technologists, medical physicists and physicians) must understand the effective doses for examinations at their own institutions and carefully approach each examination. In add… Show more
“…This paper will determine the CT-scan repetition rate and cumulative dose among pediatric patients. For example, according to the previous study, estimated effective doses per examination to children aged 0, 1, and 5 years were 6.3 ± 4.8, 4.9 ± 3.8, and 2.7 ± 3.0 mSv respectively [19]. This study will conclude all the doses for pediatric CT scans in various papers to stronger the evidence.…”
Background
The use of CT scans in pediatric patients has been increasing annually, exposing them to higher doses of radiation compared to other imaging modalities. The primary concern is the potential increased risk of stochastic effects, particularly cancer. This systematic review and meta-analysis aim to identify the factors contributing to repeat CT scans in pediatrics and their association with cancer risk. Furthermore, the study aims to determine the relative risk of cancer incidence associated with repeated CT scans in pediatric patients, as well as to identify the major cancers associated with repeated radiation exposure from CT scans in children. Additionally, the relationship between radiation dose and various factors, including scanning protocols, CT parameters, and exposure dose will be investigated.
Methods/Design:
A comprehensive systematic review will be conducted by searching relevant databases such as PubMed, Web of Science, and Scopus for studies pertaining to CT scan repetition in the pediatric population and cancer risk. The search strategy will involve keywords such as computed tomography, CT scan, cancer risk, radiation exposure, pediatrics, and cumulative doses. The database search was performed between 2012 and 2022. Two independent reviewers will assess the studies and examine the reference lists of eligible studies for additional references. Data extraction will be performed using a standardized form, and qualitative analysis will be conducted to synthesize the findings of the systematic review after assessing the risk of bias.
Discussion
By conducting this systematic review and meta-analysis, we aim to enhance our understanding of the factors contributing to repeat CT scans in pediatrics and their relationship with cancer risk. The findings will contribute to improved knowledge in this area and may inform strategies for minimizing unnecessary CT scan repetition and reducing associated cancer risks in pediatric patients.
Trial Registration:
The International Prospective Register of Systematic Reviews (PROSPERO) CRD42022342579
“…This paper will determine the CT-scan repetition rate and cumulative dose among pediatric patients. For example, according to the previous study, estimated effective doses per examination to children aged 0, 1, and 5 years were 6.3 ± 4.8, 4.9 ± 3.8, and 2.7 ± 3.0 mSv respectively [19]. This study will conclude all the doses for pediatric CT scans in various papers to stronger the evidence.…”
Background
The use of CT scans in pediatric patients has been increasing annually, exposing them to higher doses of radiation compared to other imaging modalities. The primary concern is the potential increased risk of stochastic effects, particularly cancer. This systematic review and meta-analysis aim to identify the factors contributing to repeat CT scans in pediatrics and their association with cancer risk. Furthermore, the study aims to determine the relative risk of cancer incidence associated with repeated CT scans in pediatric patients, as well as to identify the major cancers associated with repeated radiation exposure from CT scans in children. Additionally, the relationship between radiation dose and various factors, including scanning protocols, CT parameters, and exposure dose will be investigated.
Methods/Design:
A comprehensive systematic review will be conducted by searching relevant databases such as PubMed, Web of Science, and Scopus for studies pertaining to CT scan repetition in the pediatric population and cancer risk. The search strategy will involve keywords such as computed tomography, CT scan, cancer risk, radiation exposure, pediatrics, and cumulative doses. The database search was performed between 2012 and 2022. Two independent reviewers will assess the studies and examine the reference lists of eligible studies for additional references. Data extraction will be performed using a standardized form, and qualitative analysis will be conducted to synthesize the findings of the systematic review after assessing the risk of bias.
Discussion
By conducting this systematic review and meta-analysis, we aim to enhance our understanding of the factors contributing to repeat CT scans in pediatrics and their relationship with cancer risk. The findings will contribute to improved knowledge in this area and may inform strategies for minimizing unnecessary CT scan repetition and reducing associated cancer risks in pediatric patients.
Trial Registration:
The International Prospective Register of Systematic Reviews (PROSPERO) CRD42022342579
“…Moreover, potential risks are associated with radiation exposure especially in children [27,28]. A CT scan employed to evaluate the lower extremity torsional profile releases an average radiation dose of 0.3-0.5 mSv, which is substantially lower-around 5-15 times less-than the radiation exposure linked to pediatric abdominal and head CT scans [29,30]. Furthermore, scans targeting the arms and legs pose a lower risk of provoking conditions like leukemia and brain tumors in children below 10 years, relative to scans focused on the brain, chest, and abdomen [31].…”
Objective: To investigate long-term changes in femoral anteversion angle (FAA) in children with intoeing gait and to identify factors that affect FAA changes.Methods: We retrospectively analyzed three-dimensional computed tomography data from 2006 to 2022 of children with intoeing gait with ≥3 years of follow-up without active treatment. The study examined the mean changes in FAA, the effects of sex, age, and initial FAA on FAA change, and mean FAAs by age. Changes in FAA severity up to eight years of age were also observed and analyzed by sex.Results: A total of 126 lower limbs of 63 children (30 males, 33 females) with intoeing gait were included, with a mean age of 5.11±1.05 years and a mean follow-up period of 43.59±7.74 months. The initial FAA was 41.42°±8.29° and the follow-up FAA was 33.25°±9.19°, indicating a significant decrease (p<0.001). Significant correlations were observed between age and changes in FAA, as well as between initial FAA and changes in FAA (r=0.248, p=0.005; r=-0.333, p<0.001). At age 8 years, only 22 limbs were classified as having mild FAA severity.Conclusion: During the follow-up period, children with intoeing gait had a significant decreased in FAA. No significant difference in FAA change was found between sex, but younger children and those with greater initial FAA were more likely to have decreased FAA. However, most children retained moderate to severe severity of increased FAA. Further studies are required to validate these findings.
“…Based on data provided by the United Nations Scientific Committee on Effects of Atomic Radiation (UNSCEAR), it is estimated that nearly half a million patients benefit from CT examinations everyday [21]. This widespread CT utilization raised the potential radiation risks particularly in children, such as cancer risk, over-exposures, or unjustified use of imaging [7,[22][23][24][25][26][27][28][29][30][31]. This issue directed recent CT researches and innovations to radiation dose reduction methods with preservation of resulting image quality [5,8,9].…”
Section: Discussionmentioning
confidence: 99%
“…The increasing awareness of potentially harmful effects associated with radiation exposure led to optimization of CT scans according to the principle of reducing radiation doses to "as low as reasonably achievable" (ALAR A) [7,8]. This was achieved by the development of a variety of dose reduction techniques, such as tube current modulation, lowered tube voltage, adaptive beam collimation, and partial scanning.…”
Section: Introductionmentioning
confidence: 99%
“…Most of the available studies in literature declared the role of ASIR with reduction of tube voltage for radiation dose reduction and preservation of resulting CT image quality. Moreover, many studies mentioned that the use of high levels of ASIR algorithm reconstruction yields softened resulting CT images with concern that fine anatomical features may be obscured [6,7,[15][16][17][18]. However, the innovated third generation of ASIR, ASIR-V has provided better noise reduction than the older ASIR generations, with resultant better image resolution [14,19].…”
Background: With widespread use of pediatric head CT, it is critically important to protect patients from radiation hazards, using reduced dose CT techniques. In this regard, adaptive statistical iterative reconstruction-V (ASIR-V) algorithm can decrease image noise, generating CT images of reasonable diagnostic quality with less radiation. The objective of this study was radiation dose assessment, quantitative and qualitative evaluation of reduced dose pediatric head CT using ASIR-V 60% and 80% reconstruction. Results: Retrospective analysis was performed on two groups of pediatric head CT examinations, a reduced dose CT examination group with ASIR-V reconstruction (ASIR group) (n = 27) and a standard dose CT examination group without ASIR reconstruction (non-ASIR group) (n = 14). The average effective dose (ED) of ASIR group was significantly lower than that of the non-ASIR group (1.04 ± 0.1 mS vs 3.48 ± 0.45 mS; p = 0.001). Quantitative analysis revealed comparable results of signal to noise ratio (SNR) and contrast to noise ratio (CNR) of ASIR and non-ASIR groups (p > 0.05). Qualitative evaluation of resulting images by two readers revealed comparable results of both ASIR and non-ASIR groups (p > 0.05) with excellent inter-reader agreement (κ = 0.97). Both quantitative and qualitative assessment demonstrated better ASIR-V 80% than ASIR-V 60% reconstructed images. Conclusion: ASIR-V algorithm is a promising technology for effective dose reduction of pediatric head CT with preservation of diagnostic image quality.
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