Estimation of dominance effects related to mastitis and production traits for CXCR1 gene using logistic regression analysis in dairy cattle

Bagheri, Masoumeh; Zahmatkesh, Azadeh

doi:10.1016/j.aggene.2016.11.006

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…In addition to health traits, the CXCR1 gene has been linked to performance traits in cattle. Genetic variations in CXCR1 have been associated with milk production traits, including milk yield, composition and somatic cell count (Bagheri & Zahmatkesh, 2017; Galvao et al, 2011). These variants may also impact the success of reproductive processes, such as conception rates, pregnancy maintenance and embryo survival.…”

Section: Introductionmentioning

confidence: 99%

Association of CXCR1 gene polymorphism with clinical mastitis, reproductive disorders and performance traits in Hardhenu (Bos taurus × Bos indicus) cattle

Pushpa

Magotra

Bangar

et al. 2023

Reprod Domestic Animals

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The present study investigated the presence of CXCR1 gene polymorphisms and their association with clinical mastitis, reproductive disorders and performance traits in Hardhenu cattle. Genotyping of the targeted SNP rs211042414 (C>T) at the g.106216468 loci of the CXCR1 gene was performed through PCR amplification and Bsa1 restriction enzyme digestion. The genotypic frequencies revealed three genotypes: CC, CT and TT, with the C allele being the most prevalent. Significant associations were found between the targeted SNP and clinical mastitis occurrence using chi‐square and logistic regression analyses. The CC genotype showed higher susceptibility to clinical mastitis with a higher odds ratio of 3.47 compared to TT (1.00) and CT (2.90) genotypes (p < .05). Furthermore, least squares analysis revealed significant associations between genotypes and performance traits such as total milk yield, 305‐day milk yield and peak yield (p < .05). The CC genotype exhibited higher milk yields than CT and TT genotypes, indicating a positive association between the C allele and increased milk production. These findings have practical implications for the genetic improvement of Hardhenu cattle. Incorporating the identified CXCR1 gene polymorphisms into existing selection criteria can help enhance disease resistance and milk production traits. However, further validation with a larger sample size is necessary to strengthen the observed associations and ensure their practical applicability.

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Section: Introductionmentioning

confidence: 99%

Association of CXCR1 gene polymorphism with clinical mastitis, reproductive disorders and performance traits in Hardhenu (Bos taurus × Bos indicus) cattle

Pushpa

Magotra

Bangar

et al. 2023

Reprod Domestic Animals

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Dominance effects estimation of TLR4 and CACNA2D1 genes for health and production traits using logistic regression

Bagheri

Zahmatkesh

2017

J Genet

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Knowledge of nonadditive variance and genetic effects can be helpful in explaining the total genetic variation formost of the traits. The objective of this study was to estimate dominance effects of several single-nucleotide polymorphism (SNP) genotypes for the production traits and clinical mastitis residual (CMR), in Holstein dairy cattle in a case-control study. Records of 305 days lactation were obtained for production traits and CMR. Animals were selected based on extreme values for CMR from mixed model analyses. Samples were genotyped for four SNP-single genotypes and their associations with production traits (breeding values for protein and fat yield, and protein and fat percentage) were estimated by applying logistic regression analyses. Calculation of contrast between both homozygous and heterozygous genotypes permitted to estimate dominance effects, which ranged from -0.49 to 0.35 standard deviation units for the production traits and clinical mastitis (CM), respectively. Results showed that the dominance effects may be important in contribution of total genetic effects for production traits and CM. Therefore, evaluation of animals based on additive variance alone and disregarding nonadditive effects may lead to failure in selection programmes and exactly estimating the genetic variation. The method that we used would help breeders in accurately estimation of genotypic values in a new genomic selection scenario including dominance effects.

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A new competing risks model for predicting prepayment and default using data mining

Zeng¹,

Lin²

2017

2017 2nd International Conference on Image, Vision and Computing (ICIVC)

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Estimation of dominance effects related to mastitis and production traits for CXCR1 gene using logistic regression analysis in dairy cattle

Cited by 3 publications

References 29 publications

Association of CXCR1 gene polymorphism with clinical mastitis, reproductive disorders and performance traits in Hardhenu (Bos taurus × Bos indicus) cattle

Association of CXCR1 gene polymorphism with clinical mastitis, reproductive disorders and performance traits in Hardhenu (Bos taurus × Bos indicus) cattle

Dominance effects estimation of TLR4 and CACNA2D1 genes for health and production traits using logistic regression

A new competing risks model for predicting prepayment and default using data mining

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