Estimation of community-wide multi-chemical exposure via water-based chemical mining: Key research gaps drawn from a comprehensive multi-biomarker multi-city dataset

Kasprzyk-Hordern, Barbara; Proctor, Kathryn; Jagadeesan, Kishore; Lopardo, Luigi; O'Daly, Kieran J.; Standerwick, Richard; Barden, Ruth

doi:10.1016/j.envint.2020.106331

Cited by 40 publications

(32 citation statements)

References 34 publications

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“…Furthermore, in WBE, for the back-calculation of population exposure and intake, the four referenced articles followed the same methodology [ 45 , 46 , 47 , 48 ]. First, they calculated the daily mass load (MLday) of the selected biomarkers, following Equation (3).…”

Section: Environmental and Dietary Exposure To Pesticidesmentioning

confidence: 99%

“…Kasprzyk-Hordern et al [ 45 ] carried out a complex study investigating biomarkers of several groups of pollutants in untreated wastewater from five cities in southwest England on a large scale. Nine fungicides and herbicides were studied along with other compounds such as pharmaceuticals, illicit drugs, lifestyle chemicals, and personal care products.…”

Section: Direct Approachesmentioning

confidence: 99%

“…The analytes extracted by SPE were analyzed by LC and UHPLC–QqQ-MS/MS systems mostly in positive ionization mode. Kasprzyk-Hordern et al [ 45 ], in addition to ESI + , tested ESI − using a mobile phase consisting of water/methanol; however, in this case, NH 4 F was used instead of acetic acid to favor the ionization of negatively charged molecules. Furthermore, Devault et al [ 47 ] determine metabolites of chlordecone by LLE extraction, adding NaCl to the sample and using a mixture of hexane/acetone (85/15, v/v ).…”

Section: Direct Approachesmentioning

confidence: 99%

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Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

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Background: Pesticide residues are a threat to the health of the global population, not only to farmers, applicators, and other pesticide professionals. Humans are exposed through various routes such as food, skin, and inhalation. This study summarizes the different methods to assess and/or estimate human exposure to pesticide residues of the global population. Methods: A systematic search was carried out on Scopus and web of science databases of studies on human exposure to pesticide residues since 2019. Results: The methods to estimate human health risk can be categorized as direct (determining the exposure through specific biomarkers in human matrices) or indirect (determining the levels in the environment and food and estimating the occurrence). The role that analytical techniques play was analyzed. In both cases, the application of generic solvent extraction and solid-phase extraction (SPE) clean-up, followed by liquid or gas chromatography coupled to mass spectrometry, is decisive. Advances within the analytical techniques have played an unquestionable role. Conclusions: All these studies have contributed to an important advance in the knowledge of analytical techniques for the detection of pesticide levels and the subsequent assessment of nonoccupational human exposure.

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Section: Environmental and Dietary Exposure To Pesticidesmentioning

confidence: 99%

Section: Direct Approachesmentioning

confidence: 99%

Section: Direct Approachesmentioning

confidence: 99%

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Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

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“…Information on prescribing quantity of different APIs in a particular year and a year-long trend of an API are interesting for various applications including community health monitoring [23,[34][35][36], environmental monitoring [37,38], policy interventions [39], and environmental and water quality management [21,40,41]. This tool can facilitate research in these aspects and in the identi cation of most prescribed API in particular region or in a practice and able to identify the variation across the prescription of API over a period or region or practice.…”

Section: Pranavizmentioning

confidence: 99%

PrAna: An R package to calculate and visualize England NHS primary care prescribing data

Jagadeesan¹,

Grant²,

Griffin³

et al. 2021

Preprint

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Background The objective of this work to calculate prescribed quantity of an active pharmaceutical ingredient (API) in prescription medications for human use, to facilitate research on the prediction of amount of API released to the environment and create an open-data tool to facilitate spatiotemporal and long-term prescription trends for wider usage. Design We have developed an R package, PrAna to calculate the prescribed quantity (in kg) of an APIs by postcode using England’s national level prescription data provided by National Health Service, for the years 2015–2018. Datasets generated using Prana can be visualized in a real-time interactive web-based tool, PrAnaViz to explore spatiotemporal and long-term trends. The visualisations can be customised by selecting month, year, API, and region. Results PrAnaViz’s targeted API approach is demonstrated with the visualisation of prescribed quantities of 14 APIs in the Bath and North East Somerset (BANES) region during 2018. Once the APIs list is loaded, the back end retrieves relevant data and populates the graphs based on user-defined data features in real-time. These plots include the prescribed quantity of APIs over a year, by month, and individual API by month, general practice, postcode, and medicinal form. The non-targeted API approach is demonstrated with the visualisation of clarithromycin prescribed quantities at different postcodes in the BANES region. Conclusion PrAna and PrAnaViz enables the analysis of spatio-temporal and long-term trends with prescribed quantities of different APIs by postcode. This can be used as a support tool for policymakers, academics and researchers in public healthcare, and environmental scientist to monitor different group of pharmaceuticals emitted to the environment and for prospective risk assessment of pharmaceuticals in the environment.

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“…Solid components of water systems (suspended particulate matter and river sediments) are important to include due to analyte partitioning and chemical accumulation. Additionally, by including drug metabolites in analyses, a distinction can be made between drug excretion and drug disposal [ 8 ]. This method encompasses analysis of multiple matrices, for parent drugs and several associated metabolites in order to provide a comprehensive WBE tool—supporting ‘one health’ research and tackling the AMR challenge.…”

Section: Introductionmentioning

confidence: 99%

Multiresidue antibiotic-metabolite quantification method using ultra-performance liquid chromatography coupled with tandem mass spectrometry for environmental and public exposure estimation

Holton

2021

Anal Bioanal Chem

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This manuscript describes a new multiresidue method utilising ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) via multiple reaction monitoring (MRM), for the identification and quantification of 58 antibiotics and their 26 metabolites, in various solid and liquid environmental matrices. The method was designed with a ‘one health’ approach in mind requiring multidisciplinary and multisectoral collaborative efforts. It enables comprehensive evaluation of antibiotic usage in surveyed communities via wastewater-based epidemiology, as well as allowing for the assessment of potential environmental impacts. The instrumental performance was very good, demonstrating linearity up to 3000 μg L−1, and high accuracy and precision. The method accuracy in several compounds was significantly improved by dividing calibration curves into separate ranges. This was accompanied by applying a weighting factor (1/x). Microwave-assisted and/or solid-phase extraction of analytes from liquid and solid matrices provided good recoveries for most compounds, with only a few analytes underperforming. Method quantification limits were determined as low as 0.017 ng L−1 in river water, 0.044 ng L−1 in wastewater, 0.008 ng g−1 in river sediment, and 0.009 ng g−1 in suspended solids. Overall, the method was successfully validated for the quantification of 64 analytes extracted from aqueous samples, and 45 from solids. The analytes that underperformed are considered on a semi-quantitative basis, including aminoglycosides and carbapenems. The method was applied to both solid and liquid environmental matrices, whereby several antibiotics and their metabolites were quantified. The most notable antibiotic-metabolite pairs are three sulfonamides and their N-acetyl metabolites; four macrolides/lincomycins and their N-desmethyl metabolites; and five quinolone metabolites. Graphical abstract

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Estimation of community-wide multi-chemical exposure via water-based chemical mining: Key research gaps drawn from a comprehensive multi-biomarker multi-city dataset

Cited by 40 publications

References 34 publications

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

PrAna: An R package to calculate and visualize England NHS primary care prescribing data

Multiresidue antibiotic-metabolite quantification method using ultra-performance liquid chromatography coupled with tandem mass spectrometry for environmental and public exposure estimation

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