Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery.

Gamble, Greg; Zorn, J; Sanders, Gregory P.; MacMahon, Stephen; Sharpe, Norman

doi:10.1161/01.str.25.1.11

Cited by 196 publications

(134 citation statements)

References 36 publications

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“…Badono et al 29 investigated 104 healthy volunteers and observed a decrease in aortic compliance with advancing adult aging (r = −0.42). Gosse et al 30 measured the QKD interval and found the correlation between age and the QKD interval to be r = −0.54, and Gamble et al 31 reported the distensibility of the common carotid to be reduced with advancing age (r = −0.78). Recently Liang et al 15 reported relationships with age in 50 volunteers, CAC, r = −0.50, and aorto-femoral PWV, r = +0.58.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32] The interval consists of the Q-E time, from the onset of the Q-wave until the onset of ejection (E) at the aortic valve and the E-K time, required for transmission of the pulse wave from the aortic valve to the point of sound production under the cuff. The Q-E time is approximately 80 msec and an average E-K time of 130 msec over 40 cm gives a PWV of 3 m/s.…”

Section: Discussionmentioning

confidence: 99%

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The effect of age on vascular compliance in man: which are the appropriate measures?

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of age on vascular compliance in man: which are the appropriate measures?

et al. 1999

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“…The diagnostic challenge must be to detect abnormal structure and function in the vascular system before the development of symptoms or signs of cardiovascular disease. 46 By providing a direct assessment of abnormal structure or tone in the arterial vasculature, alterations in arterial compliance may improve risk stratification and identify individuals with early vascular damage who are predisposed to future vascular events. 47 Utilization of data from pulse contour analysis is dependent on the reliability and reproducibility of the measurement.…”

Section: Figurementioning

confidence: 99%

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

et al. 1999

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Abstract-The objective of this study was to evaluate age-related changes in pulsatile arterial function. Aging alters arterial pulsatile function and produces consistent changes in the pressure pulse contour. A reduced systemic arterial compliance that can be derived from analysis of the pulse contour is regarded as the best clinical index of impaired pulsatile arterial function and may mark the presence of early vascular damage. We analyzed intra-arterial brachial artery waveforms in 115 healthy normotensive volunteers (83 men, 32 women) and radial artery waveforms obtained with the use of a calibrated tonometer device in 212 healthy volunteers (147 women, 65 men). A computer-based assessment of the diastolic pressure decay and a modified Windkessel model of the circulation were used to quantify changes in arterial waveform morphology in terms of large artery or capacitive compliance, oscillatory or reflective compliance in the small arteries, inertance, and systemic vascular resistance. Large artery compliance and oscillatory compliance correlated negatively with age for both invasive and noninvasive groups (rϭϪ0. 50 and rϭϪ0.55; rϭϪ0.37 and rϭϪ0.66; PϽ0.001 for all). The slopes of the regression lines for the decline in oscillatory compliance with age were significantly steeper than those recorded for large artery compliance estimates. The change in blood pressure with age independently contributed to the decrease in large artery compliance but not oscillatory compliance in both groups. Consistent age-related changes were found in the pressure pulse contour by analysis of waveforms obtained invasively or noninvasively from the upper limb. The change in the oscillatory or reflective compliance estimate was independent of blood pressure change and may represent a better marker than large artery or capacitive compliance of the degenerative aging process in altering pulsatile arterial function. (Hypertension. 1999;33:1392-1398.)Key Words: age Ⅲ compliance Ⅲ resistance Ⅲ impedance A daptations in the arterial vasculature play a critical role in influencing cardiovascular hemodynamics with advancing age. 1 The generalized structural and functional changes in the arterial circulation contribute to alterations in regional blood flow, progression of atherogenesis, and the microvascular abnormalities that occur during senescence. 2 In large arteries, aging results in progressive deposition of calcium salts, fraying and fragmentation of elastin, and an increase in the number and cross-linking of collagen fibers that alter the compliance characteristics of the vessel wall. 3 A rigid aorta is less able to buffer the pulsatile output from the heart; it contributes to an increase in systolic blood pressure and left ventricular afterload and a decrease in diastolic blood pressure and impaired coronary perfusion. Recent evidence suggests that an increase in pulse pressure is accompanied by progressive vessel wall damage and atherogenesis and is associated with an increase in cardiac morbidity and mortality rates. 4,5 In addi...

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“…11 Variables such as local PWV, arterial distensibility and Young's elastic modulus assess the local intrinsic properties of the arterial wall itself and are more closely related to the biomechanical characteristics of the artery. 12,13 However, because these local variables require cumbersome and/or specialized imaging technologies such as ultrasound imaging systems (that is, echo-wall-tracking) for the peripheral arteries and MRI for the aorta, their use is limited to research laboratories. 5 We recently proposed a simple method for the evaluation of both local and regional AoStiff.…”

Section: Introductionmentioning

confidence: 99%

Assessment of aortic stiffness by local and regional methods

et al. 2011

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The stiffness of large arteries has an important role in cardiovascular hemodynamics. Aortic stiffness (AoStiff) can be assessed non-invasively with regional and local methods. In this paper, we compared these two techniques for evaluating AoStiff. Our subjects comprised of 118 consecutive patients (85 men, mean age: 49 ± 14 years). We evaluated regional AoStiff with carotid-femoral pulse wave velocity (PWV) measured with a tonometric technique and by bioelectrical impedance (BI) wave velocity (IWV). The local AoStiff was calculated from BI signals recorded at the chest. We used glyceryl trinitrate (GTN) to test the effect of peripheral vasodilatation on both methods in a subgroup of 52 patients (37 men, mean age: 52 ± 11 years). We found a significant correlation between IWV and PWV measurements (r¼0.88, Po0.0001) as well as between AoStiff and PWV measurements (r¼0.75, Po0.0001). GTN administration decreased mean arterial blood pressure by 4% (95% confidence interval: 2-8%, P¼0.002) without significant changes in AoStiff and regional IWV. Local AoStiff is correlated with regional measurements and is not influenced by changes in arterial pressure because of systemic peripheral vasodilatation.

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Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery.

Cited by 196 publications

References 36 publications

The effect of age on vascular compliance in man: which are the appropriate measures?

The effect of age on vascular compliance in man: which are the appropriate measures?

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Assessment of aortic stiffness by local and regional methods

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