Estimation of arsenic in nail using silver diethyldithiocarbamate method

Sattar

2020

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The study was designed to see the effects of tetracycline and clotrimazole on the altered skin flora (Aspergillus and Enterobacter species) in 38 patients with palmar arsenical keratosis. The skin swab and scrapping samples were collected. Tetracycline, clotrimazole and their combination were given as ointment for 3 months. Clotrimazole and tetracycline were found to inhibit the growth of Aspergillus spp. and Enterobacter spp. in vitro. A pH-dependent inhibition of the growth of microorganisms in presence of these antimicrobials was observed, which was highest at pH 8. The percentage reduction of keratotic nodular size was 32.9, 66.1, 61.1 and 32.5 in the groups treated with placebo, tetracycline, clotrimazole and the combination of both, respectively. But none of the interventions was proved statistically significant. No remarkable adverse effect was reported. In conclusion, clotrimazole or tetracycline inhibits the growth of Aspergillus spp. or Enterobacter spp. in vitro. However, there was no statistically significant clinical improvement of the palmar arsenical keratosis.

Section: Estimation Of Total Arsenicmentioning

confidence: 99%

Effects of tetracycline and clotrimazole ointments in the treatment of palmar arsenical keratosis

Ferdous

Sattar

2020

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“…The level of arsenic in the drinking water and nail was measured by silver diethyldithiocarbamate (SDDC) method (Bhuiyan et al, 2015).…”

Section: Estimation Of Arsenicmentioning

confidence: 99%

Effect of Solanum melongena peel extract in the treatment of arsenic-induced Bowen’s disease

Sarah

2018

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<p class="Abstract">The aim of this study was to see the effectiveness of <em>Solanum melongena</em> peel extract in the treatment of arsenic-induced Bowen’s disease. In total 8 patients of arsenic-induced Bowen’s disease were selected from the two arsenic-endemic areas. The peel extract containing ointment was provided to each patient and instructed him/her to apply twice daily on the site of the lesion for 12 weeks. The measurement of the lesion size as well as photograph were collected both before and at the end of the study. The mean (± SD) diameter of the lesion was 3.8 ± 1.9 cm which reduced to 2.5 ± 1.7 cm (reduction 34%). The result was statistically significant.</p>

“…The samples drinking water (50 mL) and nails (>200 mg) were collected in separate containers to estimate the amount of total arsenic by SDDC method (Bhuiyan et al, 2015). One drop of concentrated hydrochloric acid was added to the container for drinker water as preservative.…”

Section: Methodsmentioning

confidence: 99%

Pattern of skin bacteria in palmar arsenical keratosis

Khalil

Sattar

2016

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The aim of the present study was to examine the involvement of skin bacteria in the pathogenesis of keratosis. Skin swab of five different sites (palm, dorsum of the hand, chest, axilla and alar crease) from arsenic unexposed volunteer (n = 15), arsenic exposed (n = 15) and arsenicosis patients (n= 20) were collected for bacterial culture. The skin of arsenic unexposed volunteers contained Staphylococcus epidermidis and Bacillus spp. Chronic exposure to high concentration of arsenic through drinking water altered the skin bacterial pattern. The growth of Pseudomonas spp. increased in different sites of the skin. But in patient of arsenicosis, the skin of the palm shows the growth of Enterobacter spp.