Estimation of antibodies to HBsAg in vaccinated health care workers

Rao, T. V.; Suseela, IJ; Sathiavathy, KA

doi:10.4103/0255-0857.38876

Cited by 23 publications

(12 citation statements)

References 2 publications

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“…Majority were in the age range of 18–24 years and 60% were females which is similar to study by Rao et al, whereas two other studies showed male predominance [ 8 – 10 ]. The overall seroprotection rate was 88.2% irrespective of the duration of vaccination and in other studies it was 89% and 70% with sample size of 57 and 166, respectively [ 8 , 10 ]. There was a significant decline in antibody titres as the years of vaccination prolonged.…”

Section: Discussionsupporting

confidence: 88%

“…A study has shown that six (10.5%) of all successfully vaccinated persons had not attained minimal protective levels of antibody of 10 mIU/ml, six (10.5%) had antibody levels in the range of >11–100 mIU/ml, and 45 (79%) had antibody levels >101 mIU/ml [ 8 ]. Another study conducted on 112 HCWs has shown that protective antibody levels were 99.9% one year after vaccination and decreased to 80.96% and 46.16% after 5 and 10 years after vaccination, respectively [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

Sahana

Sarala

Prasad

2017

BioMed Research International

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Background Hepatitis B is one of the most important occupational hazards among healthcare workers (HCWs). This study aimed to measure the anti-HBs titres among the medical students and HCWs vaccinated against hepatitis B virus and to determine the association between anti-HBs levels and time since vaccination. Materials and Methods In this cross-sectional study, medical students and healthcare workers who had received all three doses of hepatitis B vaccination and completed at least six months after vaccination since the last dose were included. 3 ml blood was collected from subjects (n = 340) and anti-HBs titre was estimated using ELISA. Results A total of 340/400 subjects were aged between 18 and 60 years; 204 were females and 136 males. The median and interquartile range for time since vaccination were 5 and 5 years, respectively. Duration since vaccination was ≤5 years in 223 (65.5%), 6–10 years in 84 (24.7%), and >10 years in 33 (9.70%); among them, antibody titres were >10 mIU/ml in 94.1%, 79.7%, and 72.7% subjects, respectively. There was significant decline in antibody titres as duration of postvaccination increased. Conclusion The proportion of subjects who were unprotected after 5 and 10 years after vaccination were 20% and 27%, respectively. The need for a booster dose can be made mandatory at least for healthcare professionals.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

Sahana

Sarala

Prasad

2017

BioMed Research International

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“…As there is an effective vaccine for HBV, immunization has been a central strategy for most countries to reduce the burden of hepatitis B, especially in people who are infected with HIV (WHO, 2013). However, this study has witnessed that the majority of HIV positive people have not been immunized against HBV, indicating that they do not have protective levels of antibodies against HBV (Rao et al , 2008). Immediate screening of everyone with HIV and immunizing all who test negative for HBV markers, irrespective of their ARV status, is therefore the best approach to minimize HIV/HBV co-infection.…”

Section: Discussionmentioning

confidence: 96%

Hepatitis B and hepatitis C virus infections among antiretroviral-naive and -experienced HIV co-infected adults

Manyazewal

Sisay

Biadgilign

et al. 2014

Journal of Medical Microbiology

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Most HIV positive people have not been tested for viral hepatitis and their treatments have not been optimized for possible co-infections. The aim of this study was to investigate the serological pattern of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among antiretroviral (ARV)-naive and -experienced HIV co-infected adults in Addis Ababa, Ethiopia. A total of 500 frozen HIV positive serum and plasma samples collected from ARV-naive (n5250) and -experienced (n5250) adults were randomly selected and screened for HBsAg, anti-HBs, HBeAg and anti-HCV using rapid two-site sandwich immunochromatographic assay. The test was performed at Aklilu Lemma Institute of Pathobiology, Addis Ababa University. Positive specimens for HBsAg and anti-HCV markers were further confirmed using third generation ELISA. Of the 500 specimens tested, 15 (3 %), 58 (11.6 %), 3 (0.6 %), 18 (3.6 %), 3 (0.6 %) and 1 (0.2 %) were positive for HBsAg, anti-HBs, HBeAg, anti-HCV, HBsAg and HBeAg, and HBsAg and anti-HBs markers, respectively. No specimen tested positive for both HBeAg and anti-HBs, and 442 (88.4 %) individuals were non-immune to HBV. Of the 250 ARV-naive individuals, 8 (3.2 %), 33 (13.2 %), 2 (0.8 %), 10 (4 %), 2 (0.8 %), and 1 (0.4 %) were positive for HBsAg, antiHBs, HBeAg, anti-HCV, HBsAg and HBeAg, and HBsAg and anti-HBs markers, respectively. Of the 250 ARV-experienced individuals, 7 (2.8 %), 25 (10 %), 1 (0.4 %), 8 (3.2 %), 1 (0.4 %), and 0 (0 %) were positive for HBsAg, Anti-HBs, HBeAg, anti-HCV, HBsAg and HBeAg, and HBsAg and anti-HBs markers, respectively. In summary, seroprevalence of HIV/HBV and HIV/HCV coinfections was lower in Addis Ababa, Ethiopia, than in Sub-Saharan Africa and globally. HBV and HCV infections were not significantly different between HIV positive subjects who were or who were not on ARV. This suggests that the two groups have equal chance of being infected with these two viruses; despite this, disease progression could be different.

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“…Post vaccination antibody testing is essential to know the adequate immunological priming has been achieved and to identify non responders. (Rao et al, 2008). No study has so far been conducted in western Tamilnadu.…”

Section: "Highmentioning

confidence: 99%

Assessment of Hepatitis B vaccination status and needle stick injury awareness among doctors of a tertiary care medical college hospital

Sagar¹,

Rani²,

Sundararajan³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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Estimation of antibodies to HBsAg in vaccinated health care workers

Cited by 23 publications

References 2 publications

Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

Hepatitis B and hepatitis C virus infections among antiretroviral-naive and -experienced HIV co-infected adults

Assessment of Hepatitis B vaccination status and needle stick injury awareness among doctors of a tertiary care medical college hospital

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