Estimation of Anti-inflammatory and Analgesic Effects of Topical NANOCEN (Nanoliposomal Arthrocen) on Mice

Goudarzi, Ramin; Amini, Saeid; Dehpour, Ahmad Reza; Partoazar, Alireza

doi:10.1208/s12249-019-1445-5

Cited by 17 publications

(17 citation statements)

References 28 publications

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“…ROCEN has been prepared from natural oil [11] and lecithin in the liposomal structure that is well known as drug supplementation without any adverse effect in pharmacy [13]. Treatment of AD with ROCEN not only has had anti-inflammatory and analgesic effects in experimental reports but also due to its permeability property may play role in barrier homeostasis of the skin [13,16].…”

Section: Discussionmentioning

confidence: 99%

“…However, because of the very low water solubility of Arthrocen, the use of pharmaceutical carriers such as liposomes is recommended for effective skin delivery of lipophilic molecules of ASU [14][15][16]. Liposome carriers not only are versatile tools in drug delivery but also have anti-oxidative, anti-inflammatory, and wound repair properties [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Liposome carriers not only are versatile tools in drug delivery but also have anti-oxidative, anti-inflammatory, and wound repair properties [17][18][19]. Recently, we have used the topical formulation of liposomal ASU to enhance the drug efficacy in wound healing, inflammation reduction, and pain alleviation in animal models [13,16]. In the study by Goudarzi et al, ROCEN formulation has caused potentially TGF-β1 production in burnt tissues of rats resulting in wound healing acceleration and thermal pain alleviation with a long-lasting effect [13].…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Effects of Liposome Containing Arthrocen (ROCEN)) on Atopic Dermatitis in Mice

Goudarzi¹,

Eskandarynasab²,

Muhammadnejad³

et al. 2021

Preprint

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Objective: Atopic dermatitis (AD) is a chronic inflammatory skin disease caused mainly by the immune stimulus. The current study aimed to investigate the effects of liposome containing arthrocen (ROCEN) and its comparison with betamethasone (Beta) on mice subjected to AD. Methods: First of all, the risk assessment of ROCEN sensitization was done, then mice were subjected to oxazolone (Oxa) for chronic AD induction and treatment. Scratching and wiping behaviors related to dermatitis were evaluated in animals treated topically with ROCEN. The histological and immunohistochemistry analysis of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were conducted to the dorsal skin of treated rats. Results: The results showed that cutaneous administration of ROCEN on sensitized mice for 5 weeks, alleviated significantly scratching and wiping symptoms, erythema, scaling, and edema in animals’ skin. Moreover, histological indices showed that ROCEN reduced effectively leucocyte infiltration and improved skin healing parameters in AD mice. Immunohistochemically markers of IL-8 and TNF-α were hindered significantly by ROCEN in dermal tissues of mice. Conclusion: ROCEN potentiated alleviation of the AD symptoms rather than betamethasone drug in an experimental model.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Beneficial Effects of Liposome Containing Arthrocen (ROCEN)) on Atopic Dermatitis in Mice

Goudarzi¹,

Eskandarynasab²,

Muhammadnejad³

et al. 2021

Preprint

Self Cite

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“…Recently, nanoparticle-based drug delivery systems, including metal nanoparticles [ 6 ], liposomes [ 7 , 8 ] and conventional micelles [ 8 , 9 ], have been introduced into OA therapeutics to prolong residence time of small drug molecules in joint cavity. However, these systems are always loaded with limited amounts of drugs and are not smart stimulus-responsive, which can hardly meet the requirement for OA therapy.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

et al. 2020

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Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal − organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.

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“…Recently, nanoparticle-based drug delivery systems, including metal nanoparticles [6], liposomes [7,8] and conventional micelles [8,9], have been introduced into OA therapeutics to prolong residence time of small drug molecules in joint cavity. However, these systems are always loaded with limited amounts of drugs and are not smart stimulus-responsive, which can hardly meet the requirement for OA therapy.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive and hyaluronic acid-functionalized metal-organic frameworks for therapy of osteoarthritis

Xiong

Qin

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal−organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.

show abstract

Estimation of Anti-inflammatory and Analgesic Effects of Topical NANOCEN (Nanoliposomal Arthrocen) on Mice

Cited by 17 publications

References 28 publications

Beneficial Effects of Liposome Containing Arthrocen (ROCEN)) on Atopic Dermatitis in Mice

Beneficial Effects of Liposome Containing Arthrocen (ROCEN)) on Atopic Dermatitis in Mice

pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

pH-responsive and hyaluronic acid-functionalized metal-organic frameworks for therapy of osteoarthritis

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