Estimation of an age-specific reference interval for pulse wave velocity: a meta-analysis

Abstract

We constructed an age-adjusted reference curve for PWV. Using the 95th centile of this curve as a threshold (e.g. 10.94, 11.86, and 13.18 m/s for 20, 40, and 60 years old) shows construct validity, as it appears to identify medium and high CVD risk groups reasonably accurately. This reference range needs to be tested using other datasets.

Noninvasive Assessment of Arterial Stiffness Should Discriminate Between Systolic and Diastolic Pressure Ranges

“…2,3,34,35 In our patients, diastolic PWV increases 0.08 m/s per year, which corresponds well with rates reported previously for aortic PWV. 12,36 The increase in PWV measured at systolic pressure, however, is Ͼ3 times greater, namely, 0.28 m/s per year. This pattern cannot be explained completely by a pulse pressure increase with age, because the latter association was rather weak and not significant in our study population.…”

“…5 Basic studies have shown that the elastic behavior of the arterial system is nonlinear, that is, arterial stiffness is pressure dependent. 6 -11 This intrinsic property of the arterial system may have serious consequences for the quantitative assessment of arterial stiffness, and changes therein, in response to age, 12,13 physiological stress, 7 and possibly antihypertensive treatment. 14,15 Currently, arterial stiffness is assessed noninvasively either at the diastolic pressure level (aortic or carotid-femoral pulse wave velocity [PWV]) or estimated as an average over the diastolic-systolic pressure range.…”

Aortic Pulse Wave Velocity and Carotid-Femoral Pulse Wave Velocity: Similarities and Discrepancies

“…Such information is available only for a subset of patients with chronic kidney disease (11), but because different devices and different methods of measuring the pulse wave propagation distance were used in that study, it is difficult to compare the results with our present ones. In a recent meta-analysis (12), 223 studies on arterial stiffness from 1995 to 2004 were analyzed. In 25 of them the methodology of cfPWV measurement was the same as in our study, but only one paper referred to a high risk group, in which the impact of cfPWV on survival in end-stage renal disease was assessed (2).…”

“…cfPWV is a marker of the presence and quantity of calcium in the coronary arteries of healthy subjects (10) and of coronary artery disease (CAD) severity in CAD patients with chronic kidney disease (11). Recently, the age-specific reference intervals for cfPWV have been determined (12). However, the relationship between aPWV and cfPWV is not known.…”

Physical Activity Correlates with Arterial Stiffness in Community-dwelling Individuals with Stroke

“…In a meta-analysis of 11 studies, cfPWV collected from the Complior device (which was used in the current study) was 8.86 m/s among adults 23 to 72 years of age who did not have cardiovascular disease or risk factors. 35 For older adults (60-69 years of age), a reference value of cfPWV as 10.3 m/s was derived from an algorithm to convert data obtained from various instrumentation (including the Complior device). 36 Therefore, among our participants of older adults with stroke, the degree to which cfPWV is elevated relative to nonstroke cohorts is greater than the 0.5-m/s difference that is considered to be clinically meaningful 37 and further highlights the multiple issues in the stroke population that affect cardiovascular health and increases their risk for recurrent events.…”