Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells

Srinivasan, Ananth; Kausch, Kyle; Inglut, Collin; Gray, Alan; Landrigan, Matthew; Poisson, Jessica; Schroder, Jacob N.; Welsby, Ian J.

doi:10.1053/j.semtcvs.2018.02.009

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…While standard RBC transfusion increased oxygen delivery, rejuvenated units were calculated to increase oxygen utilization in the tissues based on calculations of arteriovenous oxygen content difference. For patients with robust reserve of cardiac output, standard RBC transfusion may not confer negative outcomes secondary to its increased hemoglobin oxygen affinity, but in patients with reduced cardiac reserve, treatment of perioperative anemia with rejuvenated RBC units may promote improved outcomes ( Srinivasan et al, 2018 ). This assertion is also supported by evidence of better metabolic resuscitation in an animal hemorrhage model using blood with preserved BPG and ATP versus standard storage ( Williams et al, 2020 )*, as discussed later in the section on hypoxic blood storage methods.…”

Section: Red Blood Cell Storagementioning

confidence: 99%

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

Wise,

Ott,

Joseph

et al. 2024

Front. Physiol.

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Efficient distribution of oxygen (O2) to the tissues in mammals depends on the evolved ability of red blood cell (RBC) hemoglobin (Hb) to sense not only O2 levels, but metabolic cues such as pH, PCO2, and organic phosphates, and then dispense or take up oxygen accordingly. O2 delivery is the product of not only oxygen release from RBCs, but also blood flow, which itself is also governed by vasoactive molecular mediators exported by RBCs. These vascular signals, including ATP and S-nitrosothiols (SNOs) are produced and exported as a function of the oxygen and metabolic milieu, and then fine-tune peripheral metabolism through context-sensitive vasoregulation. Emerging and repurposed RBC-oriented therapeutics can modulate either or both of these allosteric and vasoregulatory activities, with a single molecule or other intervention influencing both arms of O2 transport in some cases. For example, organic phosphate repletion of stored RBCs boosts the negative allosteric effector 2,3 biphosphoglycerate (BPG) as well as the anti-adhesive molecule ATP. In sickle cell disease, aromatic aldehydes such as voxelotor can disfavor sickling by increasing O2 affinity, and in newer generations, these molecules have been coupled to vasoactive nitric oxide (NO)-releasing adducts. Activation of RBC pyruvate kinase also promotes a left shift in oxygen binding by consuming and lowering BPG, while increasing the ATP available for cell health and export on demand. Further translational and clinical investigation of these novel allosteric and/or vasoregulatory approaches to modulating O2 transport are expected to yield new insights and improve the ability to correct or compensate for anemia and other O2 delivery deficits.

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Section: Red Blood Cell Storagementioning

confidence: 99%

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

Wise,

Ott,

Joseph

et al. 2024

Front. Physiol.

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“…Reportedly, P 50 values of both whole blood and suspended RBCs decrease significantly during the first 3 weeks of storage [22]. However, the use of rejuvenation methods to increase P 50 could improve oxygen release by stored RBCs [23,24].…”

Section: Introductionmentioning

confidence: 99%

The P ₅₀ value detected by the oxygenation-dissociation analyser and blood gas analyser

Chu

Wang

You

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Oxygen tension at 50% haemoglobin saturation (P 50 ), which reflects the degree of peripheral oxygen offloading and tissue oxygenation, plays an important role in the diagnosis and treatment of disease, as well as in transfusion research. Blood gas analysers are commonly used in clinical and obtain P 50 values through complex calculations and analysis. Oxygenation-dissociation analysers are specially designed to record the oxygen dissociation curves and obtain P 50 values of whole blood, red blood cells (RBCs), and stroma-free haemoglobin. However, whether the two equipment obtain comparable data is still uncertain. Herein, we used both equipment to detect P 50 values of blood and stroma-free haemoglobin from human and bovine sources, venous and arterial blood of beagle and rat, and stored rat blood. For human blood, both analysers yielded similar data. P 50 of the stroma-free haemoglobin and bovine blood could only be properly detected by oxygenation-dissociation analysers. Blood gas analysers showed different P 50 values, while oxygenation-dissociation analysers got similar P 50 values for arterial and venous samples. Oxygenation-dissociation analysers distinguished changes in P 50 values during RBCs storage. Compared with the blood gas analysers, oxygenation-dissociation analysers had a stronger detection capability in P 50 measurement with regard to both sample types and species.

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Rejuvenation of Banked Packed Red Blood Cells. Is it Clinically Relevant?

Omer

2018

Seminars in Thoracic and Cardiovascular Surgery

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Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells

Cited by 5 publications

References 30 publications

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

The P ₅₀ value detected by the oxygenation-dissociation analyser and blood gas analyser

Rejuvenation of Banked Packed Red Blood Cells. Is it Clinically Relevant?

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Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells

Cited by 5 publications

References 30 publications

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

The P 50 value detected by the oxygenation-dissociation analyser and blood gas analyser

Rejuvenation of Banked Packed Red Blood Cells. Is it Clinically Relevant?

Contact Info

Product

Resources

About

The P ₅₀ value detected by the oxygenation-dissociation analyser and blood gas analyser