Estimation of 24-Hour Thyroid Uptake of 1-131 Sodium Iodide Using a 5-Minute Uptake of Technetium-99m Pertechnetate

Smith, Jordan; Croft, Barbara Y.; Brookeman, Valerie A.; Teates, Charles D.

doi:10.1097/00003072-199002000-00003

Cited by 17 publications

(18 citation statements)

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“…Twenty-four hour RAI uptake was estimated using 4-hour uptake of iodine-123 [27] or 20-minute uptake of technetium-99 m [28]. Thyroid volume was estimated by ultrasound (SSA-350A; Toshiba Inc. Ltd., Tokyo, Japan) as previously reported [29].…”

Section: Methodsmentioning

confidence: 99%

Prediction of post-treatment hypothyroidism using changes in thyroid volume after radioactive iodine therapy in adolescent patients with Graves' disease

Nakatake

Fukata

Tajiri

2011

Int J Pediatr Endocrinol

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BackgroundThe goal of iodine-131 therapy for pediatric Graves' disease is to induce hypothyroidism. However, changes in post-treatment thyroid volume have not been investigated in pediatric and/or adolescent patients.ObjectiveThe aim of this retrospective study was to examine whether changes in thyroid volume predict post-treatment hypothyroidism in adolescent Graves' disease patients.Patients and MethodsWe used ultrasonography to examine changes in thyroid volume, and also assessed thyroid functions, at 0, 1, 3, 5, 8 and 12 months after iodine-131 treatment in 49 adolescents ranging in age from 12 to 19 years retrospectively. Based on thyroid function outcome at 12 months, patients were divided into two groups: 29 patients with overt hypothyroidism requiring levothyroxine replacement and 20 without overt hypothyroidism. We compared changes in post-radioiodine thyroid volume between the two groups.ResultsAbout 90% of patients whose thyroid volume at 3 months after iodine-131 administration was less than 50% of the original volume were hypothyroid by one year after treatment (positive predictive value 88%, sensitivity 75.9%, specificity 85.0%).ConclusionsWe believe ultrasonographic measurement of thyroid volume at 3 months after iodine-131 to be clinically useful for predicting post-treatment hypothyroidism in adolescent Graves' disease patients.

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Section: Methodsmentioning

confidence: 99%

Prediction of post-treatment hypothyroidism using changes in thyroid volume after radioactive iodine therapy in adolescent patients with Graves' disease

Nakatake

Fukata

Tajiri

2011

Int J Pediatr Endocrinol

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“…Tc-99m pertechnetate was intravenously administered and its accumulation to the salivary gland was faster than orally administered 131 I. However, Tc-99m pertechnetate scans can be used to predict the effect of PG massage on the salivary accumulation and excretion of 131 I, because the pharmacokinetics of Tc-99m pertechnetate is known to be similar to 131 I (24)(25)(26)(27). The plan in all subjects was that they were to have thyroid scan with Tc-99m pertechnetate and, therefore, they did not received an additional radiation burden for study purposes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Parotid Gland Massage on Parotid Gland Tc-99m Pertechnetate Uptake

Kim

Ahn

Lee

et al. 2012

Thyroid

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“…Hot nodules are more often benign than cold lesions are. The most commonly used substance is radioactive technetium-99 m [1–4]. After accumulation in the thyroid gland, gamma radiation is recorded by the gamma camera so that the thyroid is presented as an image and the function of the thyroid may be assessed.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of incidentally found thyroid nodules in computed tomography: comparison with thyroid scintigraphy

et al. 2017

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BackgroundIn our daily experience, the differentiation between a cold and hot nodule is a very important factor for further clinical management of the patient.In this study, we compared the characteristics of incidentally found thyroid nodules detected on computed tomography (CT) to thyroid scintigraphy (TS).MethodsDiagnostic reports from chest CT with intravenous contrast and TS examinations performed from January 2013 to January 2016 were analyzed retrospectively. We identified 70 subjects: 50 with thyroid nodules and 20 control subjects without thyroid nodules. The examination time of the TS was a minimum of two to four months after a chest CT. Chest CTs were performed in the arterial phase after the application of contrast media.ResultsPatients with a cold nodule had a significantly lower Hounsfield Unit (HU) Nodule(N)/Parenchyma (P) ratio values than the patients with a hot or warm nodule (P < 0.05). The cut-off HU N/P ratio value with the highest sum of sensitivity and specificity for the prediction of a functioning nodule was 69 (95% CI: 0.79–0.95).ConclusionsOur results imply that the HU N/P ratio of the thyroid nodule on the chest CT should be taken into account to assess the functionality of the nodule. A lower HU N/P ratio should alert the radiologist or nuclear medicine physician to the possibility that the nodule might be cold and thus more prone to malignancy.

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Estimation of 24-Hour Thyroid Uptake of 1-131 Sodium Iodide Using a 5-Minute Uptake of Technetium-99m Pertechnetate

Cited by 17 publications

References 0 publications

Prediction of post-treatment hypothyroidism using changes in thyroid volume after radioactive iodine therapy in adolescent patients with Graves' disease

Prediction of post-treatment hypothyroidism using changes in thyroid volume after radioactive iodine therapy in adolescent patients with Graves' disease

Effect of Parotid Gland Massage on Parotid Gland Tc-99m Pertechnetate Uptake

Characteristics of incidentally found thyroid nodules in computed tomography: comparison with thyroid scintigraphy

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