Estimation de l’âge médicolégal grâce à l’étude de la méthylation de l’ADN : revue de la littérature

Abstract

The estimation of forensic age is a key parameter (providing useful information) for criminal, legal and anthropological investigations. Medico-legal age can be defined as the reflection of the biological (not chronological) age of an individual in a judicial (research) context. This estimate initially based on the morphological study, the bone and dental radiography turned for 5 years towards the field of the epigenetics forensic. Analysis of DNA methylation is currently the best way to predict a chronological age. The development of molecular approaches for the study of this methylation continues to grow and to date more than 20 publications have shown a positive correlation between aging and change of methylation at the CpG scale. In this review, we summarize data from the literature on the identification and development of age-correlated markers in blood and other tissues. We also identify study techniques with their advantages and disadvantages.

Identification of Human Survivors in Natural Disasters Through Body Odor Analysis

“…DNA is a powerful tool for identifying individuals, particularly in situations where other identification methods are limited. DNA can be extracted from various biological samples, such as blood, saliva, and hair, and can be compared with DNA databases for identification [13].…”