Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: Relevance to protection against nitrogen mustards

Ball, C.R.

doi:10.1016/0006-2952(66)90157-2

Cited by 112 publications

(29 citation statements)

References 11 publications

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“…To examine the hypothesis that enhancement of cardiac sulfhydryl group content might ameliorate doxorubicin toxicity in mice, we initially chose to pretreat experimental animals before doxorubicin administration with pharmacologic dosages of NAC, an agent that had been shown by others to increase the nonprotein sulfhydryl level of rat spleen (32), and mouse kidney, and lung (33). In order to provide an adequate test of NAC as a protective agent, we used a dose of doxorubicin (20 mg/kg i.p.)…”

Section: Resultsmentioning

confidence: 99%

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Doroshow¹,

Locker²,

Ifrim³

et al. 1981

J. Clin. Invest.

220

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Section: Resultsmentioning

confidence: 99%

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Doroshow¹,

Locker²,

Ifrim³

et al. 1981

J. Clin. Invest.

220

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“…After slaughtering the hens, their livers and ovariums were weighed, and thyroid weight and thyroid length were recorded. The liver and thyroid tissue samples were analyzed for MDA (Xia, 1994;Marklund, 1990) and GSH (Ball, 1966;Fernandez & Videla,1981).…”

Section: Biochemical Analysismentioning

confidence: 99%

Biochemical Parameters and Histopathological Findings in the Forced Molt Laying Hens

Mert

Yildirim

2016

Rev. Bras. Cienc. Avic.

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The aim of this study was to evaluate the effects of forced molting using biochemical parameters and histopathological findings in laying hens. 36 Hyline W36 strain laying hens, 90 weeks old were chosen for this research. Eight of these chickens were randomly selected and placed in a cage as the control group before the molting program began. All the others 28 chickens were used for the forced molting program. Eight laying hens were slaughtered at the end of the molting program named as molting group. The remaining 20 hens were fed for 37 days, weighted and slaughtered when they reached the maximum egg production (80%) as postmolting group. Then, blood was analyzed for malondialdehyde, glutathione, catalase, glucose, calcium, phosphorus, albumin, globulin, total protein, triiodothyronine, thyroxine and Vitamin C. The malondialdehyde and glutathione levels of the thyroid and liver tissues were also analyzed along with an examination of the histopathological changes of the liver, ovarium and thyroid glands; and live body, liver, ovarium, thyroid weights and thyroid lengths. In conclusion, it was found that forced molting produces stress and notable side effects in hens, like the oxidant and antioxidant status of the organs, tissue weights and sizes, hormon profiles, blood biochemical and histopathological parameter changes. The activities of thyroid malondialdehyde (p<0.05), liver glutathione (p<0.01), plasma catalase (p<0.001) were significantly decreased in molting group compared to control values, while liver malondialdehyde levels were significantly increased (p<0.001) and thyroid glutathione levels had nonsignificant effect. These levels in molting hens were the first study for veterinary science.

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“…Antioxidant assays: Total serum soluble sulfhydryl groups, serum and tissue gluta thione and cysteine were assayed with the DTNB procedure (10,11), ascorbic acid by the hydrazine technique (12) and a-tocopherol by the Rindi method (13), respectively.…”

Section: Methodsmentioning

confidence: 99%