Estimation and correlative study of salivary nitrate and nitrite in tobacco related oral squamous carcinoma and submucous fibrosis

Shende, Vaishali; At, Biviji; Akarte, Nilkanth Ramji

doi:10.4103/0973-029x.125203

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…This hypothesis was validated, as we demonstrated that repeated exposure to CS led to a decrease in Bax expression and to an increase in Bcl‐2 expression. The increased cell proliferation and apoptosis resistance may thus explain how CS promotes oral pathologies, such as periodontal disease, and even cancer development and progression .…”

Section: Discussionmentioning

confidence: 99%

Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression

Alharbi

Rouabhia

2016

J of Periodontal Research

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Section: Discussionmentioning

confidence: 99%

Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression

Alharbi

Rouabhia

2016

J of Periodontal Research

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“…Although our 3D sl-µPADs needed the longer time for reaction (15 min) and the bigger volume for sample introduction (18 µL) than some work shown in Table 1 , the linear ranges and the LODs obtained in this work were comparable with those given by other sensors. Therefore, the fabricated 3D sl-µPADs provided an analytical platform to quantitatively detect nitrite and thiocyanate at the levels normally found in saliva [ 45 , 46 , 47 ]. Moreover, a heating step was added to study the possibility of the shorter testing time.…”

Section: Resultsmentioning

confidence: 99%

3D Microfluidic Devices in a Single Piece of Paper for the Simultaneous Determination of Nitrite and Thiocyanate

Yu¹,

Deng²,

Yang³

et al. 2020

Sensors

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The concentrations of nitrite and thiocyanate in saliva can be used as the biomarkers of the progression of periodontitis disease and environmental tobacco smoke exposure, respectively. Therefore, it is particularly necessary to detect these two indicators in saliva. Herein, the three-dimensional single-layered paper-based microfluidic analytical devices (3D sl-μPADs) were, for the first time, fabricated by the spraying technique for the colorimetric detection of nitrite and thiocyanate at the same time. The conditions for 3D sl-μPADs fabrication were optimized in order to well control the penetration depth of the lacquer in a paper substrate. Then, the developed 3D sl-μPADs were utilized to simultaneously detect nitrite and thiocyanate and the limits of detection are 0.0096 and 0.074 mM, respectively. What is more, the μPADs exhibited good specificity, good repeatability, and acceptable recoveries in artificial saliva. Therefore, the developed 3D sl-μPADs show a great potential to determine nitrite and thiocyanate for the assessment of the human health.

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“…For example, leafy green spinach has a basic pH and is highly rich in nitrate [ 167 ]. The high content of nitrate increases nitrite concentrations in saliva [ 106 ], which in turn could lead to toxic nitrosation of arecoline [ 168 ]. Thus, it is unlikely that spinach consumption would protect against the toxic effects of arecoline.…”

Section: Potential Dietary Measures To Reduce Adverse Effects Of mentioning

confidence: 99%

Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations

Moriel

Lin

Tanoukhy

et al. 2020

IJERPH

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Betel quid, traditionally prepared with areca nut, betel leaf, and slaked lime, has been consumed for thousands of years, mainly in the form of chewing. Originally used for cultural, medicinal, and ceremonial purposes mainly in South Asian countries, its use has recently spread across the globe due to its psychoactive, euphoric, and aphrodisiac properties. Now it is widely used as a social lubricant and source of financial profit. Unfortunately, the profit motive has led to high rates of habitual consumption with eventual conversion to addiction among young girls and boys. Moreover, the worrisome practice of including tobacco in quid preparations has grown, particularly among pregnant women. Major health concerns include increased rates of malignancy, oral pathology, and cardiovascular, hepatic, fertility, metabolic, and neuropsychiatric disorders. Metabolic disorders and insulin resistance disease states such as type 2 diabetes, obesity, and metabolic syndrome contribute to cognitive decline and neurodegeneration. Mechanistically, the constituents of areca nut/betel quid are metabolized to N-nitroso compounds, i.e., nitrosamines, which are carcinogenic at high doses and cause insulin resistance following chronic low-level exposures. From an epidemiological perspective, the rising tide of insulin resistance diseases including obesity, diabetes, and dementias that now disproportionately burden poor countries has been propagated by rapid commercialization and enhanced access to betel quid. Public health measures are needed to impose socially and ethically responsible barriers to yet another cause of global health disparity.

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Estimation and correlative study of salivary nitrate and nitrite in tobacco related oral squamous carcinoma and submucous fibrosis

Cited by 8 publications

References 11 publications

Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression

Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression

3D Microfluidic Devices in a Single Piece of Paper for the Simultaneous Determination of Nitrite and Thiocyanate

Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations

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