Estimating the survival advantage based on telomere length and serum biomarkers of aging

Zhao, Yilin; Li, Shijun; Liu, Hui

doi:10.1186/s12967-017-1267-8

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…The telomere DNA gradually shortens with cell division and is closely related to cell senescence and death. For aged people, telomere length was relatively longer in healthy people; individuals with shorter telomeres may have died before reaching an advanced age, and therefore, samples were unavailable [ 20 , 21 ]. Cawthon and his colleagues [ 22 ] measured telomere length in the blood of 143 individuals aged more than 60 years and found that the longer telomere length was correlated with a higher survival rate.…”

Section: Discussionmentioning

confidence: 99%

Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Ren

et al. 2022

BioMed Research International

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Background. The pursuit of health and longevity is the eternal theme of humanity. Guangxi has a remarkable phenomenon of longevity in long-lived regions and ranks with the highest number of longevity villages in China, thus providing a natural advantage for health longevity research. Methods. In this study, we selected 117 natives of a longevity area in Guangxi, covering a large age range (38-118 years old) as subjects to measure peripheral leukocyte telomere length (LTL). Nineteen physical examination indicators and two inflammatory factor levels were measured. Results. Pearson’s analysis revealed a significant negative correlation between age and LTL ( r = − 0.3694 , p = 0.003 ), as well as alanine aminotransferase, albumin, total bilirubin, direct bilirubin, γ-glutamyltransferase, triglycerides, Interleukin-10, and tumor necrosis factor type-α. Systolic blood pressure and blood urea nitrogen were positively correlated with age. In addition, LTL decreased in people aged 38–89 years, and an upward trend was observed in people aged older than 90 years. Conclusions. Longevity individuals have characteristics, such as longer LTL, good hepatic function, and lower triglycerides and inflammation levels.

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Section: Discussionmentioning

confidence: 99%

Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Ren

et al. 2022

BioMed Research International

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“…Chronic inflammation also causes telomere shortening by increasing cell turnover, particularly in peripheral leukocytes. Therefore, the shortening of telomeres is often associated with cellular aging and physical aging 3,6,16,25 .…”

Section: Telomere and Telomerase Activitymentioning

confidence: 99%

The Correlation of Different Intensities Exercise on Telomere Length

Ananta

Cindy²,

Sulaeman³

et al. 2022

spj

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Many studies have been conducted to establish the connection between exercise and telomere length, but still have varying results. Telomeres are reiterative DNA sequences (5'-TTAGGGn-3') which function to protect genomic DNA from enzymatic degradation. Telomere length can be used as a biomarker of aging because its repetitive structures are known to be highly relevant in the cellular aging process and the shortening of telomeres that occurs with increasing age is considered as an important contributor to aging in organisms. Several factors that affect telomere length are oxidative stress, chronic inflammation, BMI, lifestyle such as smoking, alcohol intake, stress, increased insulin resistance, and exercise. This study aims to determine the correlation of exercise at different intensities on telomere length. The method used in this study is internet search for journals and articles through several websites. The eligible criteria include studies in English language published between 2012 and 2022. The studies that report the correlation of different intensities exercise on telomere length were selected for the systematic literature review. As a result, the people who perform moderate to vigorous physical activity more in their leisure time, have longer leukocyte telomere length (LTL) and long-term resistance training may exert a protective effect on muscle telomere length in the elderly. Several studies have reported a correlation between prevention of leukocyte telomere length shortening and exercise at a certain intensity successfully.

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“…Aging is a significant and uncontrollable risk factor for death [1,24,25]; therefore, determining the effects of aging on cancers with social development is important. The different contributions of age to mortality from cancers between 2004 and 2015 could also be considered as the change in the effect of other risk factors on cancers with time (social development).…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China

Liu

2020

BioMed Research International

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Objective. To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies. Methods. The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. The role of age in mortality with time was evaluated by the interaction between time and age using a Poisson regression. Results. In ascending order of RC, the factors were uterus; other malignant neoplasms; esophagus; stomach; skin; liver; leukemia; “lip, oral cavity, and pharynx”; bladder; “colon and rectum”; breast; prostate; lung; ovary; pancreas; “lymphoid, hematopoietic, and related tissue”; and cervix cancers. According to their location on the scatter diagram, the 17 neoplasms could be divided into three groups, comprising undeveloped cancers (including four cancers), developed cancers (including three cancers), and cancers insensitive to social development. Unexpectedly, about 60% (as assessed by type of cancer) and two-thirds (as assessed by constituent ratio of death from all cancers) of cancers did not change with time. Conclusions. Most cancers may be insensitive to social development. Internal factors, including aging, may be a key factor for the occurrence of cancer.

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Estimating the survival advantage based on telomere length and serum biomarkers of aging

Cited by 6 publications

References 28 publications

Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

The Correlation of Different Intensities Exercise on Telomere Length

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China

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