Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study

Basurko, Célia; Matheus, Séverine; Hilderal, Hélène; Everhard, Sibille; Restrepo, Marion; Cuadro-Alvarez, Emma; Lambert, Véronique; Boukhari, Rachida; Duvernois, Jean-Pierre; Favre, A.; Nacher, Mathieu; Carles, Gabriel

doi:10.4269/ajtmh.16-0794

Cited by 58 publications

(32 citation statements)

References 23 publications

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“…90,91 Perinatal transmission to infants is recognised. 92 Vertical transmission is common among mothers who are viraemic at delivery. 93 But transplacental transmission is not thought to occur during infections that occur earlier during gestation, but formal data are lacking.…”

Section: Sub-populations Of Travellersmentioning

confidence: 99%

Severe dengue in travellers: pathogenesis, risk and clinical management

Halstead

Wilder‐Smith

2019

Journal of Travel Medicine

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Rationale for review Dengue is a frequent cause of febrile illness among travellers and has overtaken malaria as the leading cause of febrile illness for those traveling to Southeast Asia. The purpose is to review the risk of dengue and severe dengue in travellers with a particular focus on the pathogenesis and clinical management of severe dengue. Risk, pathogenesis and clinical management The risk of travel-acquired dengue depends on destination, season and duration of travel and activities during travel. Seroconversion rates reported in travellers, therefore, vary between <1% and >20%. The most common life-threatening clinical response to dengue infection is the dengue vascular permeability syndrome, epidemiologically linked to secondary infection, but can also occur in primary infection. Tertiary and quaternary infections are usually associated with mild or no disease. Antibody-dependent enhancement, viral factors, age, host factors and clinical experience of the managing physician modulate the risk of progressing to severe dengue. The relative risk of severe dengue in secondary versus primary infection ranges from 2 to 7. The absolute risk of severe dengue in children in highly endemic areas is ~0.1% per year for primary infections and 0.4% for secondary infections. About 2–4% of secondary infections lead to severe dengue. Severe dengue and death are both relatively rare in general travellers but more frequently in those visiting friends and relatives. Clinical management of severe dengue depends on judicious use of fluid rehydration. Conclusions Although dengue is a frequent cause of travel illness, severe dengue and deaths are rare. Nevertheless, dengue infections can interrupt travel and lead to evacuation and major out-of-pocket costs. Dengue is more frequent than many other travel-related vaccine preventable diseases, such as hepatitis A, hepatitis B, rabies, Japanese encephalitis and yellow fever, indicating a need for a dengue vaccine for travellers.

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Section: Sub-populations Of Travellersmentioning

confidence: 99%

Severe dengue in travellers: pathogenesis, risk and clinical management

Halstead

Wilder‐Smith

2019

Journal of Travel Medicine

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“…They also found transmission did occur in early pregnancies. 65 As for the general population, treatment of dengue is supportive; pregnant patients should have close monitoring should the need for emergency C-section arise. Global strategies to reduce transmission besides vaccination are similar to targeted prevention of other vector-borne diseases like malaria.…”

Section: Denguementioning

confidence: 99%

Vector-borne diseases in pregnancy

O’Kelly

Lambert

2020

Therapeutic Advances in Infection

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Vector-borne infections cause a significant proportion of world-wide morbidity and mortality and many are increasing in incidence. This is due to a combination of factors, primarily environmental change, encroachment of human habitats from urban to peri-urban areas and rural to previously uninhabited areas, persistence of poverty, malnutrition and resource limitation in geographical areas where these diseases are endemic. Pregnant women represent the single largest ‘at risk’ group, due to immune-modulation and a unique physiological state. Many of these diseases have not benefitted from the same level of drug development as other infectious and medical domains, a factor attributing to the ‘neglected tropical disease’ title many vector-borne diseases hold. Pregnancy compounds this issue as data for safety and efficacy for many drugs is practically non-existent, precluding exposure in pregnancy to many first-line therapeutic agents for ‘fear of the unknown’ or overstated adverse pregnancy-foetal outcomes. In this review, major vector-borne diseases, their impact on pregnancy outcomes, current treatment, vaccination and short-comings of current medical practice for pregnant women will be discussed.

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“…Analysis of the serological and the molecular results suggested that vertical transmission is much more persistent if the mothers are infected at a later stage of pregnancy. Valid and appropriate tests must be carried out in order to detect vertical transmission of dengue virus [22].…”

Section: Vectors and Hosts Of Dengue Virusesmentioning

confidence: 99%

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

et al. 2020

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This review features a generalized overview of dengue outbreaks, dengue pathogenesis, symptoms, immune response, diagnosis methods and preventive measures which facilitates the better understanding of the global expansion and concerns relating to the disease. Recent Findings: A recent study showed that natural killer cells of the infected person become activated soon after the infection which may help in treatment and vaccine development. A research team has also produced synthetically engineered mosquitoes that can prevent the transmission and dissemination of the dengue virus by the activation of an antibody. Furthermore, a mutation in the protein envelope of the dengue virus leads to variation in shapes, developing resistance towards the vaccine. Summary: The increasing number of reported cases indicated the worldwide distribution of the mosquito vectors, which was further facilitated by the growth in the shipping and commerce industries. The immune system, through activation of the innate and adaptive immune responses, facilitates the recruitment of an array of leukocytes which help neutralize the virus. However, the 4 different viral serotypes increases the risk of a life-threatening secondary infection due to the varying serotypes. Apart from the laboratory standard PRNT method, several other dengue detection methods such as ELISA, RT-LAMP and several optical, microfluidic and electrochemical methods have been developed. Since Dengvaxia® (CYD-TDV) has its own set of drawbacks and limitations, several companies have been investing for the production of more potential vaccines that are currently in trial.

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Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study

Cited by 58 publications

References 23 publications

Severe dengue in travellers: pathogenesis, risk and clinical management

Severe dengue in travellers: pathogenesis, risk and clinical management

Vector-borne diseases in pregnancy

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

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